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Lipase를 이용한 곤충 pheromone 합성 응용 - 생물 전환 기술
서영배,고영희 한국미생물학회 1994 微生物과 産業 Vol.20 No.1
본고에서는 화학적수법으로 다양한 특이한 기질을 제조하여 여기에 입체특이적 성질(stereospecificity)과 입체선택적 성질(steroselectivity)이 높은 생물학적 방법들 중에서 주로 lipase를 이용한 부제가수분해반응(asymmetric hydrolysis)과 그 역반응인 에스테르화반응(esterification)등을 도입한 chiral building block의 제조와 이를 이용한 곤충 생리활성물질인 pheromone의 합성에 대한 최근의 많은 예들중 상품화를 시도하고 있는 매미나방의 pheromne인 (+)-disparlure에 대하여 간단히 소개하고자 한다.
서영배,이명길,김동렬 경상대학교 경남문화연구소 1978 慶南文化硏究 Vol.1 No.1
This is a research as to how strong the pupils of local primary schools have the spirit of defeating Communists & how efficiently they are making the spirit a part of their daily life. Answers to 21 items of made-up questions given to measure the understanding degree of the spirit of defeating Communists, were collected from nearly fifteen hundred pupils in local primary schools and were analyzed with comparative accurative accuracy. The common results obtained from these materials are to be summarized as follows: 1) A good stock of the theoratical knowledge on Communism is not equipped with, but through the continual education for defeating Communists and anti-Communist education, a lot of fragmentary knowledge on Communism must have been learned and by trying to know the knowledge, pupils are sure to have the thorough spirit of defeating Communists. 2) The change of administrative districts made by hand of the Communists, the Communists' despotism, and a cunning tactic for the aggression against Korea are not known to the pupils in details. It is so imperative that the more concrete and methodical education for defeating Communists should be carried out gradually in their every school and home life. 3) In general, the education for defeating Communists in local primary schools does not seem to be so effective as we've expected. Therefore, a special and technical counterplan must be required urgently to strengthen the education for defeating Communists.
Lipase를 이용한 (S)-3-acetoxy-2-methylpropanol의 제조
서영배,서연찬,이갑득 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2
Captopril, α-tocopherol, erythromycin A, muscone과 같은 의약품, 향료등 생리활성물질의 합성에 있어서 유용한 중간원료로 이용되는 광학활성인 D-(-)-β-hydroxyisobutyric acid를 제조하기 위하여 그 전구체로 (S)-3-acyloxy-2-methylpropanol을 선정하여 lipase의 부제가수분해반응을 이용하여 이의 개발을 시도하였다. 대칭성 기질 2-methyl-1,3-propanediol diacetate 2를 다양한 lipase를 사용하여 부제가수분해(asymmetric hydrolysis)시킨 결과 lipase PS(Amano 제약, Pseudomonas sp.)의 경우는 phosphate buffer pH 7.0 조건하에서 광학순도(optical purity) 95% e.e.의 (R)-(-)-3-acetoxy-2-methylpropanol을 80% 수율로 생산하였으며, lipase AY(Candida rugosa)의 경우는 phosphate buffer pH 6.5/isobutyl alcohol (1/1), O℃의 조건하에서 목적으로 한 (S)-3-acetoxy-2-methylpropanol 3을 광학순도 약 60% e.e.로 생산하였다. Optically active carboxylic acid, D-(-)-β-hydroxyisobutyric acid {(D)-(-)-HIBA} is a useful chiral starting material for the preparation of enantiomerically pure bioactive compounds which have a chiral methyl carbon center in the molecule such as captopril, α-tocopherol, erythromycin A, muscone and so on. (S)-3-Acetoxy-2-mthylpropanol can be used as the precursor of (D)-(-)-HIBA, that is, chemical oxidation of the hydroxyl group and subsequent hydrolysis of acyl group in (S)-3-acetoxy-2-methylpropanol affords D-(-)-β-hydroxyisobutyric acid. (S)-3-acetoxy-2-methylpropanol was prepared by lipase-catalyzed asymmetric hydrolysis. In the enzymatic hydrolysis system, lipase AY (Candida rugosa) provided the expected (S)-3-acetoxy-2-methylpropanol in 60% e.e. of the enantiomeric purity under the phosphate buffer and organic co-solvent system.
徐榮培,李龍求,李永喆,李太元 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1
In order to investigate the hematopoietic effects of Pseudostellariae Radix various experiment about hematopoiesis were studied. The results were obtained as follows: 1. In the proliferous effect of bone marrow cells, water extracts of Pseudostellariae Radix played an important role on the proliferating bone marrow cells compared with control group. 2. The water extracts of Pseudostellariae Radix activated the bone marrow cells. 3. The water extracts of Pseudostellariae Radix promoted the proliferation of the bone marrow cells into cluster, BFU-E, CFU-GEMM. 4. In the bone marrow cells treated with CTX, the water extracts of Pseudostellariae Radix promoted the SCF, EPO, IL-4, IL-6 gene expression, but gene expression of its receptors, c-kit, EPO-R, TPO, c-mpl, EKLF, GATA-1 were not promoted significantly. According to the above results, water extracts of Pseudostellariae Radix promoted not only the differentiation of the bone marrow cells into CFU-GEMM which mother cell of erythrocytes, thrombocytes, monocytes and macrophages, but also the differentiation of the bone marrow cells into BFU-E. On the other hand, in the gene expression that have a lot of hematopoietic effects in the early differentiation of haematopoietic stem cells by promoting the gene expression of SCF, EPO, IL-4, IL-6 and so forth. Above results also demonstrates that the water extracts of Pseudostellariae Radix have somewhat meaningful effects in hematogenesis but not sufficient to explain its mechanisms about hematogenesis, therefore further deep studies should be accomplished about its mechanisms.