mRNA Expression of SLC5A5 and SLC2A Family Genes in Papillary Thyroid Cancer: An Analysis of The Cancer Genome Atlas

서성환,김윤학,고태식,정대천,이치승,장전엽,차원재,한명은,김성장,김인주,박경준 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.6

Purpose: The present study investigated the dynamics and prognostic role of messenger RNA (mRNA) expression responsible for18F-fluorodeoxyglucose (FDG) uptake in FDG positron emission tomography (PET) and radioactive iodine (131I) uptake in wholebodyradioactive iodine scans (WBS) in papillary thyroid cancer (PTC) patients. Materials and Methods: The primary and processed data were downloaded from the Genomic Data Commons Data Portal. Expressiondata for sodium/iodide symporter (solute carrier family 5 member 5, SLC5A5), hexokinase (HK1–3), glucose-6-phosphatedehydrogenase (G6PD), and glucose transporter (solute carrier family 2, SLC2A1–4) mRNA were collected. Results: Expression of SLC5A5 mRNA were negatively correlated with SLC2A1 mRNA and positively correlated with SLC2A4mRNA. In PTC with BRAF mutations, expressions of SLC2A1, SLC2A3, HK2, and HK3 mRNA were higher than those in PTC withoutBRAF mutations. Expression of SLC5A5, SLC2A4, HK1, and G6PD mRNA was lower in PTC without BRAF mutation. PTCswith higher expression of SLC5A5 mRNA had more favorable disease-free survival, but no association with overall survival. Conclusion: Expression of SLC5A5 mRNA was negatively correlated with SLC2A1 mRNA. This finding provides a molecular basisfor the management of PTC with negative WBS using 18F-FDG PET scans. In addition, higher expression of SLC5A5 mRNA wasassociated with less PTC recurrence, but not with deaths.

신도의 공동생활

서성환 장로회신대학교 2004 敎會와 神學 Vol.58 No.-

Primary Undifferentiated Pleomorphic Sarcoma of the Left Atrium that Presented as Acute Pulmonary Edema

서성환,박태호,유정남,차광수,김무현,김영대,우종수,노미숙 연세대학교의과대학 2007 Yonsei medical journal Vol.48 No.1

A 37-year-old woman was admitted to Dong-A University Hospital for rapidly progressive congestive heart failure. Transthoracic echocardiography demonstrated a large mass with a stalk that appeared to be a myxoma on the posterior wall of the left atrium. However, the histological diagnosis was undifferentiated pleomorphic sarcoma. We report a case of primary undifferentiated pleomorphic sarcoma of the left atrium with acute pulmonary edema caused by mitral inflow obstruction.

임계-쌍 경로 : 테스트 생성에서의 효율성 연구

서성환 동양대학교 1999 동양대학교 논문집 Vol.5 No.1

본 논문에서는 테스트 생성 과정에서 자주 사용되는 임계의 확장 개념으로 임계-쌍을 정의한다. 그리고 임계의 특성을 나타내는 요소로서 임계성, 임계율, 임계수, 임계설정율 등을 정의한다. 이 요소들을 이용하여 임계-쌍의 사용이 단일 임계의 사용보다 더 효율적이라는 것을 입증하고, 테스트 패턴 생성 시에 임계값에 대한 평가 회수, 경로선의 탐색 회수 및 생성 시간에서 더 효율적이라는 것을 보여준다. 시뮬레이션을 통해서 ISCAS85 벤치마크 테스트 회로에 대한 실험 결과를 비교 분석한다. Critical is used frequently in many test generation procedures. In this paper, the critical-pair is defined as a extended concept of critical. Also, the criticality, the critical rate, the critical number, and the critical setting rate are defined which represent the characteristics of critical. In these elements, it is proved that the usage of the critical-pair is more efficient than that of the single critical. It is also showed that the critical-pair is more efficient in evaluation number of critical values when the test pattern is generated, in the number of searching lines, and the test generation time. The experimental results of the critical-pair on the ISCAS85 benchmark test circuits are compared and analyzed to the single critical using simulation.

시험 불가능 결함의 효율적인 확인에 관한 연구

서성환 東洋大學校 産業技術硏究所 1999 東洋大學校 産業技術硏究所 論文集 Vol.1 No.1

This paper presents a new algorithm to identify untestable faults in combinational logic circuits. In a combinational logic circuit, an untestable fault is always caused by a redundancy of circuits. We find a redundancy of their circuits by analyzing regions between fanout stems and reconvergent gates. This paper introduce to identify untestable faults in combinational logic circuits using the critical-pair path is defined as a extended concept of critical path. And this method is efficient comparing to other methods. The experimental simulation results of other methods for the ISCAS85 bench mark testing circuit are analyzed.

Increased Risk of Hospitalization for Heart Failure with Newly Prescribed Dipeptidyl Peptidase-4 Inhibitors and Pioglitazone Using the Korean Health Insurance Claims Database (Diabetes Metab J 2015;39:247-52)

서성환,서기현,정창희,김미경,진상만,황유철,이병완,김재현 대한당뇨병학회 2015 Diabetes and Metabolism Journal Vol.39 No.4

임계-쌍 경로를 이용한 시험 불가능 결함의 확인

서성환,안광선 대한전자공학회 1999 電子工學會論文誌, C Vol.c36 No.10

본 논문은 조합 논리회로에서의 시험 불가능한 결함(untestable faults)을 확인하는 새로운 알고리즘 RICP(Redundancy Identification using Critical-pair Paths)를 제시한다. 조합 논리회로에서의 시험 불가능 결합은 회로의 과잉(redundancy)에 의해서 발생한다. 회로의 과잉은 팬 아웃 스템(fanout stem)과 재결집 게이트(reconvergent gate)의 영역을 분석함으로서 찾을 수 있다. 시험 불가능한 결함들은 임계 경로의 확장된 개념인 임계-쌍 경로를 이용하여 스템 영역을 분석함으로써 확인되어진다. RICP 알고리즘이 FIRE(Fault Independent REdundancy identification) 알고리즘보다 효율적이라는 것을 보여준다. ISCAS85 벤치마크 테스트 회로에 대한 두 알고리즘의 실험 결과를 비교하였다 This paper presents a new algorithm RICP(Redundancy Identification using Critical-pair Paths) to identify untestable faults in combinational logic circuits. In a combinational logic circuit, untestable faults occurred by redundancy of circuits. The redundancy of a circuit can be detected by analyzing areas of fanout stem and reconvergent gates. The untestable faults are identified by analyzing stem area using Critical-Pair path which is an extended concept of critical path. It is showed that RICP is better than FIRE(Fault Independent REdundancy identification) algorithm in efficiency. The performance of both algorithms was compared using ISCAS85 bench mark testing circuits.

FFR에서의 임계-쌍 경로를 이용한 효율적인 테스트 생성

서성환,안광선 대한전자공학회 1999 電子工學會論文誌, C Vol.c36 No.4

본 논문에서는 테스트 생성 과정에서 자주 사용되는 임계의 확장 개념으로 임계-쌍을 정의한다. 그리고 임계의 특성을 나타내는 요소로서 임계성, 임계율, 임계설정율 등을 정의한다. 이 요소들을 이용하여 임계-쌍의 사용이 단일 임계의 사용보다 더 효율적이라는 것을 입증하고, FFR에서의 테스트 패턴 생성 시에 임계값에 대한 평가 회수, 경로선의 탐색 회수 및 생성 시간에서 더 효율적이라는 것을 보여준다. 시뮬레이션을 통해서 ISCAS85 벤치마크 테스트 회로에 대한 실험 결과를 비교 분석한다. Critical is used frequently in many test generation procedures. In this paper, the critical-pair is defined as a extended concept of critical. Also, the criticality, the critical rate, the critical number, and the critical setting rate are defined which represent the characteristics of critical. In these elements, it is proved that the usage of the critical-pair is more efficient than that of the single critical. in FFR, it is also showed that the critical-pair is more efficient in evaluation number of critical values when the test pattern is generated, in the number of searching lines, and the test generation time. The experimental results of the critical-pair on the ISCAS85 benchmark test circuits are compared and analyzed to the single critical using simulation.

Glycemic Variability: How Do We Measure It and Why Is It Important?

서성환,김재현 대한당뇨병학회 2015 Diabetes and Metabolism Journal Vol.39 No.4

Chronic hyperglycemia is the primary risk factor for the development of complications in diabetes mellitus (DM); however, it is believed that frequent or large glucose fluctuations may independently contribute to diabetes-related complications. Postprandial spikes in blood glucose, as well as hypoglycemic events, are blamed for increased cardiovascular events in DM. Glycemic variability (GV) includes both of these events; hence, minimizing GV can prevent future cardiovascular events. Correcting GV emerges as a target to be pursued in clinical practice to safely reduce the mean blood glucose and to determine its direct effects on vascular complications in diabetes. Modern diabetes management modalities, including glucagon-related peptide-1-based therapy, newer insulins, modern insulin pumps and bariatric surgery, significantly reduce GV. However, defining GV remains a challenge primarily due to the difficulty of measuring it and the lack of consensus regarding the optimal approach for its management. The purpose of this manuscript was not only to review the most recent evidence on GV but also to help readers better understand the available measurement options and how the various definitions relate differently to the development of diabetic complications.

Increased Risk of Hospitalization for Heart Failure with Newly Prescribed Dipeptidyl Peptidase-4 Inhibitors and Pioglitazone Using the Korean Health Insurance Claims Database

서성환,서기현,정창희,김미경,진상만,황유철,이병완,김재현 대한당뇨병학회 2015 Diabetes and Metabolism Journal Vol.39 No.3

Background: We assessed the association of dipeptidyl peptidase 4 inhibitors (DPP4i) with hospitalization for heart failure (HF) using the Korean Health Insurance claims database. Methods: We collected data on newly prescribed sitagliptin, vildagliptin, and pioglitazone between January 1, 2009 and December 31, 2012 (mean follow-up of 336.8 days) to 935,519 patients with diabetes (518,614 males and 416,905 females) aged 40 to 79 years (mean age of 59.4 years). Results: During the study, 998 patients were hospitalized for primary HF (115.7 per 100,000 patient-years). The incidence rate of hospitalization for HF was 117.7 per 100,000 per patient-years among patients on pioglitazone, 105.7 for sitagliptin, and 135.8 for vildagliptin. The hospitalization rate for HF was greatest in the first 30 days after starting the medication, which corresponded to a significantly higher incidence at days 0 to 30 compared with days 31 to 360 for all three drugs. The hazard ratios were 1.85 (pioglitazone), 2.00 (sitagliptin), and 1.79 (vildagliptin). The incidence of hospitalization for HF did not differ between the drugs for any time period. Conclusion: This study showed an increase in hospitalization for HF in the initial 30 days of the DPP4i and pioglitazone compared with the subsequent follow-up period. However, the differences between the drugs were not significant.