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서광식 ( Sik Suh Kwang ),김종우 ( Jong Woo Kim ),김영설 ( Young Seol Kim ) 경희대학교 경희의료원 2010 慶熙醫學 Vol.26 No.2
Regenerative medicine is the process of creating living, functional tissues to replace organ function lost due to disease, injury or aging by using stem cells. Dental regenerative medicine is the most useful model for the strategies of stem cell based therapy in the future. Tooth-derived stem cells are isolated from the dental pulp, periodontal ligament, apical papilla and other tooth structures. Stem cells found in teeth are regenerative, with the extraordinary potential to develop into many different cell types, including neurons, adipocytes, osteoblasts and odontoblasts. Dental stem cells are among the most powerful in the body and replicate at a faster rate and for a longer period of time than other types of stem cells, This review focuses on the different sources of dental stem cells and their relative efficiency and summarizes current knowledge, challenges, and limitations in the use of stem cells for dental regenerative medicine.
배양된 부신종양세포에서 각종 펩타이드에 대한 코티졸 분비반응
최영길(Young Kil Choi),김성운(Sung Woon Kim),양인명(In Myung Yang),김진우(Jin Woo Kim),김영설(Young Seol Kim),김광원(Kwang Won Kim),서광식(Kwang Sik Suh),팽정령(Jeong Young Paeng) 대한내과학회 1988 대한내과학회지 Vol.34 No.5
N/A We have observed the regulatory effects of some brain peptide on cortisol secretion of human cultured adrenal tumor cells. The results were as followings; 1) Until 100 pg of ACTH stimulated cortisol secretion with dose dependent fashion and maximal response was detected at 100 pg concentration (average 16,6 times than control level). 2) Also CRF stimulated cortisol secretion gradually to 1 ng concentration and maximal response was detected at 1 ng level (average 2.1 tiems than control value). 3) Synergism was observed at combined stimulation of ACTH and β-endorphin. 4) The various degrees of suppression was observed by 10-8M concentration of SMS 201-995, but suppressive effect was outstanding on stimulated by CRF (40% suppressed) Therefore we had further investigate the possibilities of suppressive activity of synthesis and release of cortisol in the adrenal tumor with somatostatin analog.
당뇨유발 마우스에서의 hollow fiber 로 캡슐화한 췌장소도의 이종이식
이무열(Moo Yeol Lee),우정택(Jeong Taek Woo),김성운(Sung Woon Kim),양인명(In Myung Yang),김진우(Jin Woo Kim),김영설(Young Seol Kim),김광원(Kwang Won Kim),최영길(Young Kil Choi),서광식(Kwang Sik Suh) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
Background: We have investigated whether xenograft of the pancreatic islets encapsulated in hollow fiber (Amicon, H1P 30~43 type) could normalize blood glucose levels and could secrete insulin normally in perifusion system. Method: Mice (ICR) made diabetic with 180 mg/kg streptozotocin were intraperitoneally transplanted with encapsulated rat pancreatic islets, Hollow fibers (Amicon, H1P30~43 type, nominal cutoff MW; 30,000) have been used for encapsulation of rat islet cells. Result: Rat islets in the hollow fibers secreted insulin normaly in perifusion system. Xenograft of rat islets in the hollow fibers produced and maintained temporarily normoglycemia in the recipient mice. Conclusion: These results suggest that xenograft of rat islets in the hollow fibers need further study for biocompatability, transplantation site, and islet cell counts.
Craves병 환자에서 백혈구와 갑상선 조직의 HLA-DR β 유전자 부위의 비교
양인명,우정택,팽정령,서광식,김성운,김영설,김광원,최영길 경희대학교 유전공학연구소 1989 遺傳工學論文集 Vol.1 No.-
정상 갑상선세포에서는 HLA-DR 항원이 발현되지 않았으나, 그레이브스병 환자의 갑상선세포 표면에는 HLA-DR 항원이 발현됨이 보고되어, 이러한 현상은 이 질환의 자가면역 기전에 중요한 역할을 하고 있을 것으로 생각되고 있다. 한편 최근 DR이나 DQ 유전자의 상부 159kb 이내에는 이들의 발현을 조절하는 유전자가 존재함이 알려져 있고, 이 부위의 구조적인 변화로 인하여 DR DQ 유전자의 발현을 유도하는 여러 가지 핵내 인자들과 interferon-r 와 같은 외부인 자들이 보고되고 있다. 그러나 그레이브스병에서 이들 유전자 부위의 구조적인 변화에 관해서는 아직 보고가 없다. 이에 본 연구자 등은 이러한 가능성 여부를 규명하고자 2명의 전형적인 그레이브스병 환자의 수술 우 얻어낸 갑상선 조직에서 RNA를 분리한 우 DR β유전자를 소식자로 northem blotting을 하여 mRNA의 발현을 관찰하였으며, 말초혈액 백혈구와 갑상선 조직으로부터 분리된 DNA를 EcoRI BamHI. HindⅢ PvuⅡ TaqI, PstI등의 6가지 제한효소로 소화한 후 DR β유전자를 소식자로 하여 RFLP 양상을 비교한 결과, 환자 모두에서 mRNA의 발현이 관찰되었으나, 환자 모두에서 6가지 제한효소에 의한 RFLP 양상이 동일하였다. 이러한 결과는 Graves병 환자의 DR 유전자의 발현에 있어서 이 유전자 부위의 구조적인 변화가 관여할 가능성이 적음을 시사하는 사실이라고 사료되나 향후 더 많은 예와 더 많은 제한효소를 이용한 주시가 필요할 것이다. The requirement for major histocompatibility antigen class Ⅱ molecules in the recognition of antigen by helper T cells suggests that the expression of class Ⅱ antigen may be important in the initiation and prolongation of immunopathology. HLA class Ⅱ antigenes are expressed on the surface of thyrocytes of the patients with graves disease. The increased expression of class Ⅱgene can be induced by trans acting factor such as interferon However the possibility of rearrangement of their regulatory genes has not been explored so far. We studied the mRNA expression in the thyrocytes of 2 patients with Graves' disease and compared the restriction fragment length polymorphism (RFLP) between thyroid and peripheral leukocyte DNA. The prominent expression of mRNA was observed in the thyroid tissues of all the two patients. But we did not find any difference in RFLP pattern in both patients. These results suggest the possibility that the rearrangement of the regulatory gene located in the upstream of DR- β gene can be a role in expression of DR antigen is less likely.