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한국인 만성 B형 간염 바이러스 ( HBV ) 보유자에서 HBV 유전자형 - 일차 중합 효소 반응법에 의한 온전한 B 형 간염 바이러스 증폭 및 그의 염기 서열 -
김학철(Haak Cheoul Kim),서검석(Geom Suk Seo),김용성(Youg Sung Kim),송우건(Woo Gun Song),문형배(Hyung Bae Moon),조지현(Jie Heun Cho) 대한내과학회 2001 대한내과학회지 Vol.61 No.5
N/A Background : Hepatitis B virus (HBV) is major source of chronic liver disease in Korea. However this virus might have different nucleotide sequence according to races, different region, etc. Recently the novel method that allows sensitive amplification with dramatically decreased mis-incorporation has developed. We determined to get the major form of HBV nucleotide sequence from whole sequencing data of 26 Korean HBV carriers. Methods : HBV DNA were collected from 26 Korean chronic HBV carriers. We used the novel PCR with pfu for the amplification of HBV DNA, and specific primers were made with combination sequence bases of non-HBV part and HBV parts which were located head and tail in the virion. Then whole length of HBV were directly sequenced and analysed. Result : HBV DNA was consisted of 3215 bases in 20 cases of 26 Korean chronic HBV carriers. And the remainder had smaller or larger number due to deletion, insertion or both in pre-S2 and S gene. They were 99.03% homology of their nucleotide sequence and belong to genotype C. The variability of nucleotide sequence was significantly higher in the singly coding region (SCR) than doubly coding region (DCR), and also high in pre-S1 and pre-S2 gene among the DCR. Hot-spots were more frequently found in the SCR, pre-S1 and pre-S2 gene. Conclusion : In Korean chronic HBV carriers, HBV is consisted of 3215 nucleotides, and belongs to genotype C. And it might exist one genotype with the variability in Korea.(Korean J Med 61:479-488, 2001)
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염동한 ( Dong Han Yeom ),임평숙 ( Peong Suk Im ),조은영 ( Eun Young Cho ),최창수 ( Chang Soo Choi ),김태현 ( Tae Hyeon Kim ),서검석 ( Geom Seok Seo ),김학철 ( Haak Cheoul Kim ) 대한내과학회 2007 대한내과학회지 Vol.73 No.4
일차성 간 결핵은 특이 증상이 없고 드물어, 진단이 늦어지거나 다른 질환으로 오인되기 쉽다. 저자들은 소화불량과 체중감소를 주소로 내원해 시행한 복부 컴퓨터 촬영에서 간 좌엽에 단일공간점유병변으로 담관암을 의심하였으나 복부초음파 유도하 간 종괴 생검에서 만성 육아종성 염증 및 괴사 소견을 보여 간 결핵으로 진단하였다. 치료로 동반된 위 배출구 폐쇄에 의한 증상이 심해 간좌엽 절제술 및 위-공장 문합술을 실시하였고, 이후 6개월간 항결핵제를 복용하였다. 본 증례를 통해 간내에 단일 종괴의 감별진단에 있어 일차성 간결핵을 고려해야 하고 반드시 간조직 생검을 통해 감별진단이 이루어져야 함을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Primary hepatic tuberculoma is a rare malady that is not accompanied by local symptoms, so the diagnosis can frequently be delayed or misconceived as other disease. We report here on an unusual case of primary hepatic tuberculoma that was misconceived as a cholangiocarcinoma on the imaging study. A 54-year-old man presented with dyspepsia and weight loss for 1 month. Abdominal computerized tomography demonstrated a solitary space-occupying lesion on the left lobe of the liver that suggested there was a cholangiocarcinoma accompanied with gastric outlet obstruction. The lesion was diagnosed by the ultrasonographic guided liver biopsy as a chronic granulomatous inflammation with necrosis, and the patient was treated via surgical resection with gastro-jejunostomy followed by antituberculosis chemotherapy. Twelve months later, no evidence of recurrence was noted when examining the patient`s symptoms and the imaging studies.(Korean J Med 73:423-427, 2007)
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최경숙,서검석 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2
Bezoars can be classified into phytobezoar, trichobezoar, and lactobezoar according to nature of composite materials. Most of bezoars are located in the stomach, with the small intestine being the second common site. In contrast it is uncommon to observe bezoar in the colon. Recently we experienced one clinical case wherein an old woman suffered from obstruction of the colon caused by colonic beaoar. We successfully performed application of endoscopic polypectomy snare and lithotripsy basket into removal of bezoar from the colon in this patient without any clinical complications.
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만성 B형 간염 바이러스 보유자에서 Core Promoter의 다양성
김학철,김용성,서검석,송우건 대한소화기학회 1999 대한소화기학회지 Vol.34 No.5
Background/Aims : The core promoter (CP) is included in X-gene of hepatitis B virus (HBV), and is composed of a upstream regulatory sequence (URS) and a basic core promotor (BCP) which is regulated by URS. Nucleotide (nt) mutation of CP might influence the expression of precore mRNA and pregenomic mRNA and the activity of liver disease. Thus, we investigated the relation between the nucleotide mutations in CP and their effects on HBeAg status, and severity of disease in chronic B viral liver disease. Methods : Samples were obtained from 7 chronic asymptomatic carriers, 9 patients with chronic hepatitis and 20 cirrhotic patients with HBV. Polymerase chain reaction and DNA analysis for CP were performed. Results : Cirrhotic group was older than asymptomatic carrier group and chronic hepatitis group. In BCP, point mutations were observed in 10 positions. Among them, nts 1753, 1762 and 1764 were frequently mutated, and the mutations at the nts 1762 and 1764 were accompanied (double mutation). In URS, point mutations were observed in 19 positions. Among these, nt 1653 (α-box) had significantly high mutation rate and the mutation at nt 1653 was closely associated with mutations at nts 1762/1764 in chronic liver disease and HBeAg (-) groups. Conclusions : The α-box of URS is closely related with double-mutation in BCP and HBeAg status in chronic B viral liver disease.
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