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지연 표본 대응 과제에서 나타나는 젊은 남성 강박장애 환자의 작업기억 결손
부영준,박진영,김찬형,김세주,Boo, Young Jun,Park, Jin Young,Kim, Chan-Hyung,Kim, Se Joo 대한불안의학회 2022 대한불안의학회지 Vol.18 No.1
Objective : Impaired working memory has been known to play an important role in the pathophysiology of obsessive-compulsive disorder (OCD) with growing evidence. Delayed matching-to-sample task (DMST) is a working memory task which have an advantage in analyzing several different working memory processes in one task. However, most of the studies have failed to reveal the working memory impairment with the DMST. The aim of this study was to identify whether working memory deficit in OCD can be evaluated with the DMST. Methods : The participants included 20 OCD patients and 20 healthy volunteers. Working memory was evaluated with the DMST with two different working memory loads. Accuracy of response and mean response time were measured. Results : OCD patients showed a significantly longer reaction time and lower accuracy in DMST compared to healthy controls in the task with high working memory loads. Moreover, the difference in accuracy showed interaction with the working memory load. Conclusion : The present results indicate that working memory deficit in patients with OCD can be evaluated with the DMST. The findings also suggest that previous negative behavioral results using the DMST were from low working memory load of the task.
부영준,김세주 대한불안의학회 2021 대한불안의학회지 Vol.17 No.1
Treating obsessive-compulsive disorder (OCD) is a difficult challenge since less than a half of the OCD patients show a significant treatment response to 1st line treatment. Therefore, various treatment tools including brain stimulation methods have been studied to solve the treatment-resistance of OCD. Transcranial direct current stimulation (tDCS) is one of the emerging treatment options for OCD. In this review, literatures on tDCS for OCD treatment were evaluated by assessing the treatment effects and safety issues. In most studies, tDCS caused a significant improvement in treatment-resistant OCD without serious adverse event, although its settings including electrode positions and polarity remain unestablished. Further studies are needed to develop protocols for applying tDCS in OCD and to strengthen the evidence of its efficacy.
부영준,김세주,강지인,Boo, Young Jun,Kim, Se Joo,Kang, Jee In 대한불안의학회 2015 대한불안의학회지 Vol.11 No.1
Objective : Impaired response inhibition has been suggested to play an important role in the pathophysiology of obsessive-compulsive disorder (OCD). The aim of this study was to evaluate the response inhibition in patients with OCD, by using the Go/NoGo paradigm, and to better understand its associations with clinical symptoms. Methods : The participants included 63 OCD patients and 80 healthy volunteers matched in age and sex. response inhibition was evaluated using computerized Go/NoGo task, in which their commission error rates, omission error rates, and mean response times were measured. The severity of clinical symptoms in the OCD patients was assessed using Montgomery-Asberg Depression Scale and Yale-Brown Obsessive Compulsive Scale. Result : OCD patients showed significantly impaired inhibition and higher omission errors rates despite their slower response time, compared to normal controls. Clinical symptoms were not correlated with commission errors and omission errors. Conclusion : The present results indicate that impairment in response inhibition may play a critical role in the pathophysiology of OCD as a trait. These findings suggest that deficit of response inhibition may contribute to developing and maintaining clinical symptoms such as compelling need to repeat certain actions in patients with OCD.
김준규,부영준,이충언,고광진,정재훈,성현환,백민기,전성수,한덕현 대한비뇨의학회 2023 Investigative and Clinical Urology Vol.64 No.1
Purpose: We investigated whether endoscopic interventions, including laser endoureterotomy and balloon dilatation following hormone therapy, are a good choice to treat ureteral obstruction due to ureteral endometriosis instead of laparoscopic or open surgery. Materials and Methods: Patients with ureteral obstruction due to endometriosis who underwent endoscopic intervention between 2004 and 2021 were reviewed. Patients with other causes of ureteral obstruction or previous ureteral surgery were excluded from the study. The primary endpoint was the 3-month success rate of endoscopic intervention with or without hormone therapy. Secondary endpoints were the success rate of endoscopic intervention between the hormone-treated and hormone-untreated groups at 6 months and the success rate according to the hormone therapy response of endometriosis at 3 and 6 months. Results: Eighteen patients with 19 ureter units were evaluated in this study, including 12 patients receiving hormone therapy and six patients not receiving hormone therapy. Among patients receiving hormone therapy, one patient had bilateral ureteral obstruction. The success rate of endoscopic intervention was higher in patients who received hormone therapy than in those who did not receive hormone therapy three months after endoscopic intervention (76.9% vs. 0.0%, p=0.003). The same result was also found 6 months after endoscopic intervention (75.0% vs. 0.0%, p=0.005). In addition, the success rates were higher in the hormone-responsive group than in the non-responsive group (100.0% vs. 57.1%), although the difference was not statistically significant (p=0.122). Conclusions: Ureteral obstruction caused by endometriosis can be effectively treated by endoscopic intervention with hormone therapy in select patients.