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RISS 인기검색어
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- 저자 : 변영로(Young Rho Byun) (검색결과 5 건)
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경피흡수제형의 in vitro 약물방출실험을 위한 연속확산 장치의 개발
변영로(Young Rho Byun),최영권(Young Kweon Choi),정서영(Seo Young Jeong),김영하(Young Ha Kim) 대한약학회 1990 약학회지 Vol.34 No.3
An automated, simple, and reliable method was developed for determining in vitro drug release rate from transdermal delivery dosage forms. The patch is held in position in the heating block by sandwiching it between the middle plate and the bottom plate of diffusion cell. The dissolution profile of the commercially available transdermal scopolamine patch was determined over a 72-h period, and the results were compared with those obtained with other methods; paddle-over-disk method, reciprocating method, and diffusion cell method. It was demonstrated that the flow-through method is equivalent in terms of release rate profile and accumulated released drug amount over the lifetime of the dosage form tested. Also this method is simple, reliable and reproducible. Therefore, this technique can be used in a quality control for assuring product uniformity.
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피막과 팽윤을 이용한 고분자 기질에서의 약물의 조절방출
김영하,변영로,장호남 한국화학공학회 1989 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.27 No.4
약물의 열적 불안정성과 용매와의 반응성을 피하기 위하여 고분자 기질을 팽윤시켜 약물을 봉입하는 방법을 고안하여 고분자 기질로 된 약제를 제조하였다. 고분자 기질은 hydrogel인 p-HEMA로 제조하여 모델약물인 citidine diphosphate coline(중추신경제)의 방출기전을 연구하였다. 또한 고분자사슬에 이온을 갖지 않는 p-HEMA와 음이온을 갖는 polyacrylate에 대해 pH에 따른 약물 방출기전의 차이를 분석하였다. 그 결과 p-HEMA는 팽윤이 일어남으로써 약물 방출곡선에 분계점이 나타났으며 polyacrylate는 음이온을 가짐으로써 pH에 따라 팽윤도가 변하였고 pH가 높을수록 팽윤도와 약물의 방출속도가 증가하였다. HEMA와 methlmethacrylate의 공중합체에 생체분해성 고분자인 polylactide로 코팅 막을 형성한 제형을 제시하였으며 이 시스템에서의 약물 방출기전 및 고분자 기질의 두께에 따른 변화를 고찰하였다. 이 제형은 생체분해성 막이 초기의 약물 방출속도를 억제함으로써 sustained release pattern을 유도하였다. In order to avoid a thermal instability and a reaction of drug with solvents, a method was devised to load a drug in a polymer matrix by swelling. Using p-HEMA hydrogel as polymer matrix, the release mechanism of a model drug, citidine diphosphate coline (CNS stimulant), was studied. Also analyzed was the difference in the pH-related release mechanism of p-HEMA which has a non-ionic polymer chain and polyacrylate which has negative ions on the polymer side chain. For p-HEMA, its break-point on the drug release curve occured due to swelling and degree of swelling did not change pH. On the other hand, swelling polyacrylate differed pH: the higher the pH, the higher the degree of swelling and faster the release rate. A formulation with a bioerodible coating membrane of polylactide was introduced to the co-polymer of HEMA and methylmethacrylate. The difference in the drug release mechanism and changes relative to the polymer thickness in this system was observed. The formulation allows the bioerodible membrane to suppress the initial rate of drug release mechanism, which led to the sustained release pattern.
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고분자 분산 매트릭스로부터의 약물방출에 관한 확산 및 용출 제어 모델
김영하,정서영,변영로,최영권 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.2
A numerical model for diffusion and dissolution controlled transport from dispersed matrix is presented. The rate controlling process for transport is considered to be diffusion of drug through a concentration gradient coupled with time-dependent surface change and/or disappearance of the dispersed drug in response to the dissolution. The transport behavior of drug was explained in terms of v parameter: v value means a ratio of diffusion time constant and dissolution time constant. This general model has wide range of application from where release is controlled by the diffusion rate to where release is governed by the dissolution rate. Based on this model, theoretical drug concentration, particle size distributions in the polymer matrix system and the resulting release rate were also investigated.
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김영하,정서영,변영로 한국약제학회 1989 Journal of Pharmaceutical Investigation Vol.19 No.2
The multilayered monolithic type transdermal delivery device has been designed and analyzed by a numerical analysis. The device consists of three layered polymer matrices which posess the different diffusion parameters, respectively. The purpose of this study was to design an ideal transdermal drug delivery device which is capable of initial burst and zero order release later on. Numerical modelings were simulated for a dispersed and a dissolved multilayered monolithic system. The results showed that the dispersed multilayered monolithic system could meet the requirements for an ideal transdermal delivery device.
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