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Tc-99m DTPA 뇌조조영술에서 48시간 지연영상의 유용성
범희승,송호천,김지열 ( Hee Seung Bom,Ho Chun Song,Ji Yeul Kim ) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.3
Usually t.he persistence of ventricular activity in Tc 99m DTPA cisternography is determined using 24 hour images in our country, However, the 24 hour image is regarded as an insufficient data by many investigators. They prefer 48 hour image, The aim of the present study was to evaluate the feasibility and usefulness of 48 hour delayed imaging in Tc-99m DTPA cisternography. We performed 48 hour cisternography using Tc 99m DTPA in 38 pat,ients with known hyclrocephalus, 37 111 MHq (1-3mCi) of Tr, 99m DTPA were injected by lumbar punct.ure. Anterior and both lateral images were obtained at 2, 6, 24 and 48 hours. The classification of hydrocephalus was done at 24 and 48 hours by two independent nuclear medicine physicians. L he 48 hour images were interpretable in all cases. In seven patient,s, the clearance of ven-tricular activity was noted only on 48 hours images. Therefore, their classification was changed from type V to type III. Sixteen of 38 patients were underwent shun(operations. Clinical improvement was noted in 13 patients(1/1 of type II, 3/6 of type Ill, 8/9 of type 1V ). One case who showed a changing pattern from IV to lll a showed no clinical improvement after shunt operation. In conclusion, the 48 hour delayed imaging was feasible and useful technique in Tc 99m DTPA cisternography.
카이틴 , 카이토산 , EDTA , DTPA 의 방사성스트론튬 ( Sr-85 ) 착화물 형성에 관한 비교 연구
범희승,김영호,김지열 ( Hee Seung Bom,Young Ho Kim,Ji Yeul Kim ) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.4
Purpose : Chitin and chitosan are nontoxic natural chelators that chelate radiostrontium effectively. The purpose of this study was to compare radiostrontium chelation of chitin and chitosan with that of well known chemical chelators, namely EDTA and DTPA. Materlats and Methods : The chelaton rates of chitin, chitosan, EDTA and DTPA were compared using a column chromatography method (Sephadex G-25M, Sweden). Three kinds of chitins and four kinds of chitosans were used. All of them were water soloble. Results : Phosphated chitosan showed the highest chelation yield of more than 97% at pH 7. All of chitins, chitosans, EDTA and DTPA showed chelation yield of more than 90% independent of varing pH level. Conclusion : Chitin and chitosan have similar chelation rate as compared with EDTA and DTPA. (Korean J Nucl Med 1998;32;391-5)
범희승(Hee Seung Bom) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.5
Recent progress of technology permits us to assess ventricular function and wall motion as well as myocardial perfusion using electrocardiographic gated myocardial perfusion single photon emission computed tomography (GM-SPECT). It is interesting that echocardiography and magnetic resonance imaging are moving in the same direction with the use of contrast medium to assess myocardial perfusio. A valid fundamental basis for a new technology is essential for a successful competition. Lee at al. report in this issue the reproducibility of serial measurement of left ventricular function including systolic wall thickening using a novel statistical method. It has important implications such as nitroglycerin or dobutamine application during GM-SPECT. The field of nuclear cardiology must continue to strive toward more sophisticated but straightforward evaluation of cardiac diseases.
범희승(Hee Seung Bom) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2
The identification of viable myocardium in patients with coronary artery disease and left ventricular dysfunction is an issue of increasing clincal relavance in the current era of myocardial revascularization. There are at least two forms of reversible myocardial dysfunction. Early reperfusion does not always lead to immediate functional improvement; rather, the return of contractility in tissue salvaged by reperfusion is delayed for hours, days or even weeks, a phenomenon that has been termed stunned myocardium. Some patients with coronary artery disease show myocardial dysfunction ar rest which are associated with reduced perfusion, and which disappear after revascularization; this phenomenon has been termed hibernating myocardium. Recently, cardiac imaging techniques that evaluate myocardial viability on the basis of perfusion contraction mismatch and inotropic reserve have gained substantial popularity and clinical success. This review focus on the application of 201T1 and Tc-99m-MIBI to address myocardial viability in patients with hibernating and stunned myocardium. It is clear that 4-hour redistribution images of 201T1 underestimate ischemia and overestimate scar. Delayed imaging and reinjection imaging have been developed for the assessment of viability. Among many protocols suggested, stress-redistribution-reinjection imaging gained most popularity. Although Tc-99m- MIBI could identify myocardial viability, 201T1 reinjection technique was regarded as superior to it. In conclusion, 201T1 stress, 4-hr rest redistribution, and reinjection imaging technique may be the most preferable method for evaluation of myocardialviability.
수용성카이토산에 의한 마우스태반을 통한 태아로의 방사성스트론튬 급성 전이 억제
김영호,범희승,김지열,Kim, Young-Ho,Bom, Hee-Seung,Kim, Ji-Yeul 대한방사선방어학회 1997 방사선방어학회지 Vol.22 No.4
카이토산은 천연무독성 착화제의 일종으로 유전적 독성이 거의 없으며, 방사성스트론튬의 마우스 체내 축적을 감소시킨다고 알려져 왔다. 본 연구에서는 임신 17일째 마우스에서 방사성스트론튬 오염전 후에 수용성카이토산을 공급함으로써 오염 후 태반을 통한 태아로의 방사성스트론튬 급성 전이를 얼마나 효과적으로 억제할 수 있는 가를 알아보고자 하였다. 수용성카이토산 분말을 50일간 일반식이와 혼합하여 10% (Group 1), 1%(Group 2)를 공급하고 임신 17일째에 방사성스트론튬을 오염시킨 군의 경우 일반식이를 공급한 대조군과 방사성스트론튬 오염 후 카이토산 10%, 1%분말을 공급한 군(Group 3, Group 4)에 비해 태반을 통한 태아로의 방사성스트론튬 전이를 효과적으로 억제함을 관찰하였다(p<0.01, 표 1).본 실험을 통해서 임신 17일째에 방사성스트론튬에 오염된 임신마우스의 경우 천연무독성 착화제인 카이토산을 장기간 전처치하였을 경우 태반을 통한 태아로의 방사성스트론튬 전이를 억제할 수 있음을 알 수 있었다. It has been reported that chitosan has little genetic toxicity as one of natural and nontoxic chelator and reduces the internal retention of radiostrontium in the mouse. This study is to examine that when water soluble chitosan is provided to the mouse on 17 days of pregnancy before and after radiostrontium contamination, how effectively it can inhibit an acute transfer of radiostrontium to fetus through placenta contaminated. Water soluble chitosan powder is mixed with general food for 60 days and 10%(Group 1) and 1%(Group 2) are provided respectively, and it is observed that the group with radiostrontium contamination on 17 days of pregnancy can inhibit more effectively the transfer of radiostrontium to fetus through placenta than control group with general food and the groups (Group 3, Group 4) with 10% and 1% of chitosan powder respectively after radiostrontium contamination (p<0.01, Table 1). It is found that when the pregnant mouse contaminated by radiostrontium on 17 days of pregnancy is prefed by chitosan, the transfer of radiostrontium to fetus through placenta can be inhibited.
인체말초혈액 림프구와 마우스골수세포에서 중기염색체 분석법과 미소핵검사법을 이용한 방사선적응반응 평가
김지열(Ji Yeul Kim),범희승(Hee Seung Bom),민정준(Jung Jun Min),송호천(Ho Cheon Song),최근희(Keun Hee Choi),정환정(Hwan Jeong Jeong),이승연(Seung Yeon Lee) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.6
N/A Purpose: Radiation adaptive response in human peripheral lymphocytes and mouse bone marrow cells was investigated using both metaphase analysis and micronucleus assay. We assessed the correlation between both tests. Materials and Methods: Two groups of the human peripheral lymphocytes and mouse bone marrow cells were exposed to low dose (conditioning dose, 0.18 Gy) or high dose (challenging dose, 2 Gy) γ-rays. The other 4 groups were exposed to low dose followed by high dose after several time intervals (4, 7, 12, and 24 hours, respectively). The frequencies of chromosomal aberrations in metphase analysis and micronuclei in micronucleus assay were counted. Results: Chromosomal aberrations and micronuclei of preexposed group were lower than those of the group only exposed to high dose radiation. Maximal reduction in frequencies of chromosomal aberrations were observed in the group to which challenging dose was given at 7 hour after a conditioning dose (p<0.001). Metaphase analysis and micronucleus assay revealed very good correlation in both human lymphocytes and mouse bone marrow cells (r=0.98, p<0.001; r=0.99, p=0.001, respectively). Conclusion: Radiation adaptive response could be induced by low dose irradiation in both human lymphocytes and mouse bone marrow cells. There was a significant correlation between metaphase analysis and micronucleus assay
간장 및 담도 : 만성간질환 및 간외담도폐쇄 환자에서 99mTc - DISIDA 간담도스캔을 통한 간세포기능의 평가
최성규 ( Sung Kyu Choi ),범희승 ( Hee Seung Bom ),양건호 ( Kun Ho Yang ),윤종만 ( Chong Mann Yoon ),김석빈 ( Suk Bin Kim ),박일종 ( Il Chong Park ),박해옥 ( Hae Ok Park ) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1
N/A Scintigraphic studies were performed in 15 normal subjecte, and 33 patients suffering from chronic parenchymal liver disease(liver cirrhosis 7, chronic hepatitis 5, hepatocellular carcinoma 1), and extrahepatic biliary obstruction(CBD stone 8, postoperative CBD stricture 4, pancreatic head ca 4, CBD ca 3, ampullary ca 1) using 99mc-DISIDA. Extraction and excretory functions of hepatocytes were evaluated with respect to liver-to-cardiac blood pool ratio(LCBPR) and washout index(WI). And relationships between these indexs and SGOT, total bilirubin levels were evaluated also. LCBPR was reduced in both patients groups(p< VVI was reduced only in those with extrahepatic biliary obstruction. LCBPR and WI were inversely correlated with total bilirubin levels(r=-0.49,-0 33, respectively).