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Cytochalasin B의 사람심방 K+ 통로 활성 차단 효과
백승우 ( Seung Woo Baik ),김태균 ( Tae Kyun Kim ),곽용근 ( Yong Geun Kwak ) 전북대학교 의과학연구소 2001 全北醫大論文集 Vol.25 No.2
본 연구에서는 cytochalasin B의 hKv1.5통로 차단기전을 명확히 구명하고 나아가 선택적 차단약물의 개발에 기여하고자, hKv1.5통로를 선택적으로 발현하는 세포주에서 cytochalasin B가 hKv1.5통로에 미치는 영향을 관찰하여 다음과 같은 결과를 얻었다. Cytochalasin B is a widely used-actin disrupting agent. Accidently, we found the non-specific channel blocking effect of cytochalasin B. In addition, voltage-gated K` channels represent the most complex group of ion channel genes expressed in cardiovascular system. The human Kv1.5 channel (hKv1.5) represents the IKur repolarizing current in human atial myocytes. Thus hKv1.5 is thought to be an unique target for atrial fibrillation. In present study, we examined the effects of cytochalasin B on hKv1.5 current stably expressed in Ltk~ cells. Cytochalasin B inhibited the hKv1.5 currents in a dose-dependent manner in the cells transfected with hKv1.5, whereas a actin polymerizing agent phalloidin did not affect the cytochalasin B-induced block. Additionally, cytochalasin B reduced the tail current amplitude recorded at -50 mV after 250 ms depolarizing pulses to +60 mV, and slowed the deactivation time course resulting in a ‘crossover’ phenomenon when the tail currents recorded under control conditions and in the presence of cytochalasin B were superimposed. These results indicate that cytochalasin B primarily block activated hKv1.5 channels in a concentration-dependent manner regardless of cytoskeleton, thereby possibly being a leading compound to develop a antiarrhythmic drug selective for atrial fibrillation.
Mn<sub>3</sub>O<sub>4</sub>를 첨가한 Al<sub>2</sub>O<sub>3</sub> 세라믹스의 소결 및 광학 특성
김진호,백승우,Kim, Jin-Ho,Baik, Seung-Woo 한국전기전자재료학회 2016 전기전자재료학회논문지 Vol.29 No.9
Alumina added with Mn3O4 up to 7.5 cat% of Mn was prepared by conventional ceramic processing, and the sintering behavior and the optical properties of which were studied as functions of Mn content. Densification and grain growth of alumina were enhanced by Mn addition up to 0.75 cat% but was leveled off at higher concentrations. XRD revealed that $Al_2MnO_4$(galaxite) was formed as a second phase in the specimens with more than 0.75 cat% of Mn. Thus it is believed that either the solid solution effect of Mn or the Zener effect of $Al_2MnO_4$ becomes predominant in the sintering of Mn-added $Al_2O_3$ according to the additive concentration. UV-VIS reflectivity(SCI) spectra of Mn-added $Al_2O_3$ consisted of smooth bottoms in 300~550 nm wavelength range and plateaus at wavelengths longer than 650 nm. The reflectivity spectrum continuously moved downward, and the specimen color became darker and thicker with increasing Mn content. The CIELAB color change with respect to standard white was also dependent on the amount of Mn added: ${\Delta}L^*$(D65) negatively increased and ${\Delta}E_{ab}^*$(D65) positively increased with increasing Mn content, probably due to Mn substitution to Al and/or the mixing effect of black $Al_2MnO_4$ as a second phase.
전기전도성을 가지는 매크로다공성 알루미노실리케이트-탄소 복합체 제조
최광민,조우석,김종영,정종열,백승우,이규형,Choi, Kwang Min,Cho, Woo-Seok,Kim, Jong-Young,Jung, Jong-Yeol,Baik, Seung-Woo,Lee, Kyu Hyoung 한국전기전자재료학회 2017 전기전자재료학회논문지 Vol.30 No.2
Recently, macroporous ceramic materials with high electrical conductivity and mechanical strength are urgently needed for semiconductor and display manufacturing devices. In this work, we obtained electro-conducting macroporous aluminosilicate ceramics having surface resistivity of 108~1,010 ohm by dispersing electro-conducting carbon in ceramic matrix. By addition of 0.5~3.0 wt% frit glass, chemical bonding between grains was strengthened, and flexural strength was enhanced up to 160 MPa as a result. We evaluated the characteristics of present ceramics as vacuum chuck module for liquid crystal display display manufacturing devices.