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백성현,이병기,윤성욱,백민기,김형곤,류영수,노용수,송은영 대한비뇨의학회 2008 Investigative and Clinical Urology Vol.49 No.3
Purpose: We examined the possibility of electroejaculation for the evaluation of fertility in the male rat. Materials and Methods: Ten 8-week-old Sprague-Dawley male rats that underwent seminal vesiculectomy were used for semen collection by electroejaculation. With a transrectal probe(60Hz, 3V, 0.5A), sign wave electric stimulation was applied to an anesthetized rat. Ejaculated semen was collected by a pipette and the volume and sperm density of the ejaculate were analyzed. Two weeks later, a second electroejaculation was performed under the same conditions with the same rats. Results: At the first attempt, all 10 rats ejaculated following electric stimulation. The mean semen volume was 8.9μl(range, 3.0-28.5μl) and the mean sperm density was 6,428/ml(range, 320-20,997/ml). At the second attempt, only 7 of 10 rats(70%) ejaculated. The mean semen volume was 5.6μl(range, 3.3-8.6μl) and the mean sperm density was 2,801/ml (range, 227-12,555/ml). Conclusions: These results indicated that electroejaculation has the possibility of being a useful method for evaluation of fertility in the male rat. (Korean J Urol 2008;49:266-270) Purpose: We examined the possibility of electroejaculation for the evaluation of fertility in the male rat. Materials and Methods: Ten 8-week-old Sprague-Dawley male rats that underwent seminal vesiculectomy were used for semen collection by electroejaculation. With a transrectal probe(60Hz, 3V, 0.5A), sign wave electric stimulation was applied to an anesthetized rat. Ejaculated semen was collected by a pipette and the volume and sperm density of the ejaculate were analyzed. Two weeks later, a second electroejaculation was performed under the same conditions with the same rats. Results: At the first attempt, all 10 rats ejaculated following electric stimulation. The mean semen volume was 8.9μl(range, 3.0-28.5μl) and the mean sperm density was 6,428/ml(range, 320-20,997/ml). At the second attempt, only 7 of 10 rats(70%) ejaculated. The mean semen volume was 5.6μl(range, 3.3-8.6μl) and the mean sperm density was 2,801/ml (range, 227-12,555/ml). Conclusions: These results indicated that electroejaculation has the possibility of being a useful method for evaluation of fertility in the male rat. (Korean J Urol 2008;49:266-270)
국내에서의 외국 상위 5개국 최상위 다출원 5개 기업의 특허활동
백성현,Baek, Seong-Hyeon 한국특허정보원 2003 Patent 21 Vol.53 No.-
세상은 우리가 생각하는 것 보다 훨씬 빠른 기술의 발전이 이루어지고 있으며, 기술의 장벽은 점점 무너져 세계 어느 곳이든 시장이 될 수 있는 글로벌화 된 세계로 급속도로 변화하고있다. 이런 시대적 변화에 따라 세계 유수의 기업들은 지적재산권을 획득하여 기술력을 인정받고 이를 통해 기술력의 우위를 점하여 자극 또는 그들의 경쟁국으로의 기술 진입을 위한 발판으로 마련하고 있는 현실이다. 그만큼 이제는 지적재산권의 획득을 위해 세계 각 국의 기업들은 R&D 투자와 지적재산권 관리에 대해 많은 노력을 하고 있다.
백성현,진공용,한영민,이용철,권근상 대한영상의학회 2013 대한영상의학회지 Vol.69 No.1
Purpose: To evaluate the clinical usefulness of tissue permeability factor in differentiating benign and malignant pulmonary lesions on dynamic contrast-enhanced (DCE) MRI. Materials and Methods: 30 patients (14 women, 16 men; median age, 64 years; age range, 41-80 years) who had a pulmonary lesion underwent DCE MR imaging at 3.0 T. Fifteen patients had lung cancer and 15 patients had benign pulmonary nodules. To calculate the perfusion parameters of the pulmonary lesions, quantitative analysis was carried out on all 30 pulmonary nodules or masses: volume transfer constant (Ktrans), reflux constant (Kep), and extravascular extracellular space volume fraction (ve). A Mann-Whitney test was used to calculate the statistical significance of quantitative perfusion parameters between malignant and benign pulmonary lesions. Receiver operating characteristic curve analysis was also performed for evaluation of sensitivity and specificity of perfusion parameters to diagnose lung cancer. Results: Malignant pulmonary lesions had higher Ktrans and ve values than benign pulmonary lesions (0.227 ± 0.065 vs. 0.133 ± 0.054; p = 0.001, 0.479 ± 0.156 vs. 0.357 ± 0.13; p = 0.038, respectively). However, the difference in Kep between the benign and malignant pulmonary lesion was not significant (0.648 ± 0.44 vs. 0.797 ± 0.93; p = 0.709). With a threshold of 0.202 (min-1), the sensitivity and specificity to diagnose malignant pulmonary lesions of the Ktrans value were 66.6% and 93.3%, respectively. Conclusion: Ktrans and ve value of perfusion parameters on DCE-MRI can help to discriminate between malignant and benign pulmonary nodules or masses.