Multi-Step LSTM 모델 기반 쿠버네티스 파드 리소스 예측 기법

백선화(Seonhwa Baek),임규정(Gyujeong Lim),유헌창(Heonchang Yu) 한국정보과학회 2023 한국정보과학회 학술발표논문집 Vol.2023 No.6

입원 암 환자의 낙상 발생 예측요인

김준년,백선화,이보섭,한미라 대한종양간호학회 2023 Asian Oncology Nursing Vol.23 No.2

Purpose/Objectives: To determine predictors of fall events in hospitalized patients with cancer, and identification of fall risk. Methods: An analysis of medical records was conducted together with a review of standardized fall reports of 565 patients admitted between January 1 and December 31, 2020. The collected data were analyzed with the chi-squared test, Fisher exact test, independent t-test, and logistic regression analysis using STATA 17 program. Results: There was a statistically significant increased fall risk; accompanied by a guardian (OR=10.30 CI=2.66~39.94), number of attachment devices (OR=1.30, CI=0.46~0.64), medication (OR=0.17, CI=0.04~0.84), pain (OR=4.73, CI=1.59~14.0), walking problem (OR=29.85, CI=9.31~95.74), chemotherapy (OR=5.20, CI=1.81~14.89), and fall risk score (OR=1.83, CI=1.50~2.24). Conclusion: These findings can serve as academic evidence to support the role of nurses in assessing the risk of fall events/accidents with regard to cancer patients and the development of individually adjusted fall assessment tools.

조현병 환자를 위한 정신사회적 및 디지털 중재

김성완,백선화,조철현 대한의사협회 2024 대한의사협회지 Vol.67 No.2

Background: Schizophrenia is a severe mental disorder that significantly impairs the daily functioning of patients that causes substantial societal and economic burden. While drug therapy is crucial for schizophrenia treatment, relying solely on antipsychotic drugs does not yield the most favorable therapeutic outcomes. Current Concepts: Integrating psychosocial interventions could result in maximized therapeutic effects for individuals living with schizophrenia. Evidence-based psychosocial interventions for schizophrenia management include cognitive behavioral therapy, family involvement, psychoeducation, supported employment programs, lifestyle adjustments for physical health, and coordinated and comprehensive early intervention services. Incorporating peer support, allowing both service users and care providers to share knowledge and their illnessrelated personal experiences, facilitates mutual assistance along the path to recovery. Moreover, growing interest follows in using digital interventions, such as wearable technology and smartphone applications, as effective therapeutic tools for illness management. Discussion and Conclusion: The above-mentioned psychosocial interventions empower individuals with schizophrenia, helping them improve their functioning, enhance their life quality, and adapt more effectively to society. Combining early medication with comprehensive psychosocial interventions, including digital technology, is crucial for the best outcomes. This approach should begin as soon as schizophrenia is diagnosed, aiming to promote recovery and overall well-being in affected individuals.

로고테라피가 코로나-19로 인한 여성 노인의 우울감 및 자아통합감 변화에 미치는 사례연구

고유선,김미경,백선화 바른역사학술원 2022 역사와융합 Vol.- No.10

본 연구는 J시 00 복지관을 이용하는 6명의 여성 노인을 대상으로 로고테라피를적용한 집단미술치료가 코로나 19로 인한 우울감과 자아통합감에 어떠한 영향을미치는지 알아보고자 하였다. 로고테라피를 적용한 집단미술치료는 주 1회 120 분씩 총 20회기(사전·사후검사 포함)를 진행하였으며 분석 결과는 다음과 같다. 우울감과 자아통합감 검사를 Wilcoxon 검정을 통해 분석한 결과 각각 유의미한 차이를 보였고, 투사 검사인 질적 분석과 프로그램 과정에서 나타난 삶의의미 변화 내용에서도 긍정적인 변화를 나타냈다. 이 연구는 로고테라피를 집단미술치료에 적용하여 코로나 19로 인해 심리적 어려움을 경험하고 있는 여성 노인에게 적극적인 삶의 의미 변화가 자아통합감과 우울감에 영향을 줄 수 있음을확인한 사례연구로써 의미가 있고, 포스트 코로나 시대에 기초자료로 활용할 수있을 것으로 시사된다.

COVID-19 시대에 중환자실 전담의사 감독 하에 두경부 전문의에 의해 시행된 기관절개술에 대한 후향적 분석 연구

한원호,이윤임,백선화,석준걸 대한후두음성언어의학회 2022 대한후두음성언어의학회지 Vol.33 No.2

Background and Objectives Tracheostomy is a relatively safe procedure, and the recent emergence of COVID-19 has raised the need to perform tracheostomy immediately in the bed of an intensive care unit (ICU) rather than an operating room. The purpose of this study was to determine the occurrence of complications related to surgical tracheotomy performed in the ICU by an ENT specialist.Materials and Method From March 2019 to January 2022, a total of 101 patients underwent tracheostomy in the ICU. Demographics and complications were classified according to postoperative period.Results Within 24 hours after the procedure, bleeding events were confirmed in 2 patients (2.0%) with mild bleeding. One case (1.0%) of ventricular fibrillation occurred shortly after the procedure. There were no complications from 24 hours to 1 week after procedure. After one week, 4 patients (4.5%) had a local infection, and 3 patients (3.4%) had a tube obstruction. During all follow-up periods, there were no serious side effects such as death, major vascular injury, pneumothroax. No complications were observed throughout the entire period in 6 COVID-19 patients.Conclusion The number of complications of surgical tracheotomy in the ICU performed by a specialist was lower than in previous studies, and there were no complications that delayed treatment or endangered life. The ENT training hospitals should provide sufficient training opportunities for residents to perform surgical tracheostomy and strive to minimize complications associated with the procedure and pre- and post-operative management under the detailed guidance and supervision of specialists.

조영제 사용 환자에 대한 효율적 관리 방안

이은혜,장수한,백선화,강지원,오용운,송훈,박수인,조인완,박태현,김영수 한국의료QA학회 2009 가을학술대회 Vol.2009 No.2

Bacillus 속 분리주가 생산하는 박테리오신의 특성 조사

함승희(Seung-Hee Ham),최낙식(Nack-Shick Choi),문자영(Ja-Young Moon),백선화(Sun-Hwa Baek),이송민(Song-Min Lee),강대욱(Dae-Ook Kang) 한국생명과학회 2017 생명과학회지 Vol.27 No.2

토하젓에서 분리한 박테리오신 생산 균주 중 상대적으로 넓은 항균스펙트럼을 나타내는 1균주를 선발하였고 16S rRNA 유전자 염기서열 분석 결과 B. subtilis E9-1와 거의 일치하는 것으로 동정되었다. B. subtilis E9-1가 생산하는 박테리오신의 물리화학적 특성을 조사하였고, 박테리오신을 정제하였다. 이 박테리오신은 B. cereus KCCM 11204, M. luteus IAM 1056, L. monocytogenes KCCM 40307, E. faecium KCCM 12118 및 S. aureus subsp. aureus KCCM 40050 등에 대해서 항균활성을 나타내었다. pH 2.0~8.0 범위에서는 안정하였으나 8.0 이상에서는 항균활성이 감소하였다. Isopropanol, ethanol 및 methanol 등의 유기용매에서 100%까지, acetone과 acetonitrile에서는 80%까지 항균활성을 유지하였다. 내열성의 경우 40~100℃에서 60분까지는 안정하게 항균활성을 보였다. 박테리오신 농도를 증가시키면서 B. cereus, L. monocytogenes, E. faecium 및 S. aureus subsp. aureus 등 시험균 4주의 감수성을 조사한 결과 농도 의존적으로 시험균의 생육이 감소하였고 이중 L. monocytogenes 의 감수성이 가장 높게 나타났다. 박테리오신의 작용양상을 알아본 결과 B. cereus와 L. monocytogenes 배양액에 박테리오신 용액을 첨가한 후 흡광도와 CFU값이 감소하여 bactericidal임을 확인하였다. 식품에 적용 가능성을 알아보기 위해 실험한 결과 3일째부터 박테리오신을 처리하지 않은 대조구에 비해 실험구에서 생균수(CFU/ml)가 감소하였다. 아세톤을 이용한 배양상등액의 농축, superdex peptide HR 10/300 column 이용한 겔여과크로마토그래피, 역상 HPLC로써 박테리오신을 정제하였다. 역상 HPLC를 통해서 정제한 박테리오신의 분자량을 tricine SDS- PAGE로 분석한 결과 약 4 kDa이었고 질량분석법으로 측정한 정확한 분자량은 3347.6 Da로 나타났다. As an effort to find a potential biopreservative, we isolated bacterial strains producing bacteriocin from fermented foods. A strain was finally selected and characteristics of the bacteriocin were investigated. The selected strain was identified as Bacillus subtilis E9-1 based on the 16S rRNA gene analysis. The culture supernatant of B. subtilis E9-1 showed antimicrobial activity against Gram-positive bacteria. Subtilisin A, α-chymotrypsin, trypsin and proteinase K inactivated the antimicrobial activity, which means its proteinaceous nature, a bacteriocin. The bacteriocin activity was fully retained at the pH range from 2.0 to 8.0 and stable at up to 100℃ for 60 min. Solvents such as ethanol, isopropanol and methanol had no effect on the antimicrobial activity at the concentration of 100% but acetone and acetonitrile reduced the activity at up to 100% concentration. Cell growth of four indicator strains was dramatically decreased in dose-dependent manner. Listeria monocytogenes was the most sensitive, but Enterococcus faecium was the most resistant. Bacillus cereus and Staphylococcus aureus showed the medium sensitivity. The bacteriocin showed its antimicrobial activity against B. cereus and L. monocytogenes via bactericidal action. The number of viable cells of L. monocytogenes started to reduce after addition of bacteriocin to the minced beef. The bacteriocin was purified through acetone concentration, gel filtration chromatography and RP-HPLC. The whole purification step led to a 6.82 fold increase in the specific activity and 6% yield of bacteriocin activity. The molecular weight of the purified bacteriocin was determined to be 3.3 kDa by MALDI-TOF/TOF mass spectrometry.