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The Current Concept of Cell Therapy for Heart Failure
백상홍 대한심장학회 2005 Korean Circulation Journal Vol.35 No.6
Cardiac repair is a dream in the field of medical science. The biological limitations to human cardiac regenerative growth require the creation of new strategies for cardiac regeneration using cells, genes and protein. Recent experimental studies and early-phase clinical trials showed stem cells have the potential to enhance myocardial perfusion and contractile performance in patients with acute myocardial infarction, advanced coronary artery disease and chronic heart failure. Overall clinical experience also suggests that stem cell therapy can be safely performed if the right cell protocol is used within the correct clinical setting. Some experimental data have shown stable stem cell engraftment due to fusion or transdifferentiation into cardiomyocyte or vascular cell lineages, which could be likely explanations for these beneficial effects. Others have proposed that transient cell retention may be sufficient to promote functional effects, e.g., by release of paracrine mediators. We should proceed cautiously with carefully designed clinical trials, and concern for patient safety must remain the key issue. The translational basic research will be required to elucidate the mechanism of stem cell therapy.
Beta Blockers in Heart Failure: More Evidence for an Old Friend
백상홍 대한의학회 2018 Journal of Korean medical science Vol.33 No.25
High resting heart rate (≥ 70 bpm) was common in heart failure with reduced ejection fraction (HFrEF; ejection fraction ≤ 35%) patients and is associated with adverse outcomes in a real-world analysis. For heart failure (HF) hospitalization, hazard appeared to be more closely associated with heart rate rather than β-blocker dose.1 Chronic β1-adrenergic receptor overactivation is well known to be an important component of pathologic ventricular remodeling, and evidence-based β-blockers are a clinically effective treatment of HFrEF owing in part to their reverse-remodeling effect. Current HF guidelines recommend the use of β-blockers based on many randomized controlled trials showing a reduced mortality rate > 35%. Although the beneficial effect of β-blocker seems undisputed, whether the target heart rate or target dose is more important in β-blocker therapy is the subject of debate. Meta-analysis showed that heart rate should be considered more important than the actual dose when tailoring β-blocker therapy. In particular, the target resting heart rate might be < 70 beats/min in HF patients. The reason why heart rate reduction is more important than β-blocker dose might be related to the large pharmacogenomic heterogeneity of β-blockers.2
백상홍,이상원,진동찬 全北大學校 學徒護國團 1981 全國大學生學術硏究發表論文集 Vol.6 No.-
This study was made to isolate anaerobic bacteria from the rectal swabs of normal healthy persons and determine the normal flora of the intestine. Rectal swab specimens were obtaianed from normal healthy adults in Seoul. As the processes of bacteriological study, anaerobic bacteria were cultured in thioglycollate semisolid broth and isolated on brain heart infusion blood supplement agar plates, and biological properties were examined including the hemolysis on blood agar plated, gas production in the fluid media. Biochemical test was performed by Minitek Anaerobic Set (BBL^*) in anaerobic Gas Pak Jar (BBL^*) The result is as followings: 1. Among the 110 rectal swab specimens, 187 strains of anaerobic bacteria were isolated. The isolates included 88 straing (47.1%) of Gram positive bacilli, 74 strains (39.5%) of Gram negative bacilli and 25 strains (13.3%) of Gram positive cocci. 2. After preservation at-80 C in thioglycollate broth, only 134 strains (71.1%) of isolates survived. Theses survivors included 76 strains of Gram positive bacilli (survival rate 86.4%), 38 strains of Gram negative bacilli (survival rate 51.4%), and 20 strains of Gram positive cocci (survival rate 80.8%). 3. From these strains, 50 strains were randomly selected by the ratio of morphologic groups of isolates for the sugar fermentation and other biochemical tests. Among these selectes and tested straing, the determined were : Eubacterium aeroficiens 27 strains(54.0%) Bacteroiaes melaninogenicus 7 strains (14.0%) Peptostreptococcus produtus 6 strains (12.0%) Eubacterium limosum 1 strains (2.0%) and the undetermined strains were : Gram negative bacilli 7 strains (14.0%) Gram positive bacilli 1 strain (2.0%) Gram negative cocci 1 strain (2.0%)
백상홍 ( Sang Hong Baek ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.3
Cardiac repair is a dream of medical science field. The biological limitations to human cardiac regenerative growth create new strategies for cardiac regeneration using cells, genes and protein. Recent experimental studies and early-phase clinical trials showed stem cells have the potential to enhance myocardial perfusion and contractile performance in patients with acute myocardial infarction, advanced coronary artery disease, and chronic heart failure. The overall clinical experience also suggests that stem cell therapy can be safely performed, if the right cell protocol is used in the right clinical setting. Some experimental data showed stable stem cell engraftment by fusion or transdifferentiation into cardiomyocyte or vascular cell lineages as likely explanations for these beneficial effects. Others have proposed that transient cell retention may be sufficient to promote functional effects, e.g., by release of paracrine mediators. We should proceed cautiously with carefully designed clinical trials and concern that patient safety must remain the key issue. The translantional basic research to elucidate the mechanism of stem cell therapy is necessary.