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사간탕(瀉肝湯)의 효능(效能)에 관(關)한 실험적(實驗的) 연구(硏究)
이원익,이원철,배향섭,구본홍,Lee, Won-Ik,Lee, Won-Chul,Bai, Hyung-Sup,Koo, Bon-Hong 대한한방내과학회 1989 大韓韓方內科學會誌 Vol.10 No.1
The present investigation was undertaken to confirm of clinical effects of Sagnating. So, experimental studies were done, especially, to ascertain whether Sagantang had pharmacological effect of analgesia, antipyresis, diuresis and decreasing blood pressure and so on. The results of the studies were obtained as follows: 1. The analgesic effects of Sagantang were obtained in mice. 2. Sagantang prolonged the duration of hypnosis which is induced thiopental-Na in mice, but it was not effective in rotor rod method. 3. Antipyretic effect of Sagantang was known on the typhoid vaccine induced fever in rats. 4. Sagantang inhibited automatic movement on the isolated ileum of mice, and antiacetylcholine effect and antibarium chloride effect of Sangantang were known on that. 5. Sangantang decreased blood pressure due to vasodilatation in anesthetized mice. 6. The effect of diuresis were noted in mice. According to the above results, clinical effects of Sagantang on oriental medical references were similar to the actual experimental results.