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- 저자 : 배학연 ( Bae Hag Yeon ) (검색결과 1 건)
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유병전 ( Yu Byeong Jeon ),배학연 ( Bae Hag Yeon ),이병래 ( Lee Byeong Lae ) 대한내과학회 1993 대한내과학회지 Vol.44 No.6
Free radical, very strong reactant, may injury to tissue react on the DNA, cell membrane lipid and protein. It was known that free radical may play an important role in the pathogenesis of varying disease such as respiratory tract disease, epidermal carcinoma, psoriasis, rheumatoid arthritis and autoimmune disease, also aging process. We studied to assess the antioxidant status of red cells in human diabetics by measuring activities of cellular antioxidant enzymes(SOD< GSHPX, Catalase), G6PDH and total glutatione level. The result were summarized as follows : 1) The superoxide dismutase altivity of red cells in diabetics (2.204±0.711 U/mg Hb) was significantly lower than in normal control group(3.070±0.721 U/mg Hb) (p<0.05). 2) The glucose 6?phosphate dehydrogenase (G6PDH) activity of red cells in diabetics (0.648±0.241 U/mg Hb) was significantly higher than in normal control group (0.456±0.190 U/mg Hb) (p<0.05). 3) The superoxide dismutase activity of red cells in diabetics over 10 years duration (1.96±0.92 U/mg Hb) was significantly lower than in normal control group (3.07±0.72 U/mg Hb) (p<0.05), also glutathione peroxidase activity of red cells in diabetics over 10 years duration (0.74±0.17 U/mg Hb) was significantly lower than in normal control group (1.81±0.48 U/mg Hb), in diabetics below 5 years duration (1.26±0.38 U/mg Hb) and in diabetics 5 to 10 years duration (1.45±0.42 U/mg Hb) (p<0.01). 4) The catalase activity of red cell in diabetics associated with retinopathy (2.93±0.51 U/mg Hb) was significantly lower than in D.M without retiopathy (4.01±0.28 U/mg Hb) (p<0.01). 5) The glutathione peroxidase activity of red cell in diabetics associated with retinopathy (0.74±0.27 U/mg Hb) was significantly lower than in D.M without retinopathy (1.47±0.54 U/mg Hb) (p<0.05) and in normal control group (1.81±0.48 U/mg Hb) (p<0.01). 6) The glutathione peroxidase activity of red cells in diabetics associated with nephropathy (1.10±0.39 U/mg Hb) was significantly lower than in normal control group (1.81±0.48 U/mg Hb) (p<0.05), also total glutathione levels in D.M with nephropathy (10.61±48 nM/mg Hb) was significanthy lower than in D.M without nephropathy (15.90±4.21 nM/mg Hb) (p<0.05). These results suggest that tissue antioxidant status may be an important factor in the etiology and complication of diabetes mellitus, but it is not clear wheather tissue antioxidant system was affected, and additional study will be needed for a full understanding of the role that free radical play in the antioxidant defense systems.
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