웹 서비스 기반의 클라이언트 OLAP API와 큐브 브라우징에의 응용 사례

배은주,김명,Bae, Eun-Ju,Kim, Myung 한국정보처리학회 2003 정보처리학회논문지D Vol.10 No.1

이기종 플랫폼간의 데이터 교환과 통합을 위한 표준 기술로 XML과 웹 서비스 기술이 각광을 받고 있다. 이러한 기술을 지원하는 XML/A는 클라이언트 응용과 데이터 분석 엔진이 인터넷 상에서 데이터를 교환할 수 있도록 하는 SOAP 기반의 XML 통신 API이다. 데이터가 XML 문서 형태로 교환된다는 점에서 XML/A는 플랫폼 독립적이지만, 클라이언트 응용 개발자들은 서버에 데이터를 요청할 때마다 XML 문서를 생성해야 하고, 서버가 보내는 XML 데이터 검색을 위해 별도의 XML 쿼리 언어를 사용해야 하는 단점이 있다. 본 연구에서는 윈도우즈 환경의 클라이언트 응용 개발자들이 XML/A의 OLAP 관련 서비스를 편리하게 사용할 수 있도록 하는 상위 수준의 클라이너트 OLAP API인 XMLMD를 설계하고 구현하였다. XML/A와 XML/A의 관계는 OLEDB for OLAP과 ADOMD의 응용 사례로써 데이터의 다차원적 분석결과를 인터넷을 통해 제공하는 웹 OLAP 큐브 브라우저도 개발하였다. 이 브라우저는 전송된 데이터를 XML, HTML, 엑셀, 그래프 등의 다양한 형태로 제공한다. XML and Web Services draw a lot of attention as standard technologies for data exchange and integration among heterogeneous platforms XML/A, which supports such technologies, is a SOAP based XML APl that facilitates data exchange between a client application and a data analysis engine through the Internet. The fact that the XML format is used for data exchange makes XML/A to be platform-independent. However. client application developers have to go through a tedious Job of treating the same type of XML documents fur downloading data from the server. Also, an XML query language is needed for extracting data from the XML documents sent by the server. In this paper, we present a high level client OLAP API, called DXML, for the client application developers in the windows environment to easily use the OLAP services of XML/A. XMLMD consists of properties and methods needed for OLAP application development. XMLMD is to XML/A what ADOMD is to OLEDB for OLAP. We also present a web OLAP cube browser that is developed using XMLMD. The browser display's data in various formats such as XML, HTML, Excel, and graph.

유전자 재조합 인형 과립구 콜로니 자극인자 DA-3030 의 일반약리작용

배은주(Eun Ju Bae),신명수(Myeong Soo Shin),김순회(Soon Hoe Kim),강수형(Soo Hyung Kang),김원배(Won Bae Kim),양중익(Jung Ick Yang) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.3

Neutropenia is a major dose-limiting factor in cancer chemotherapy diminishing its usefulness and increase patient`s susceptibility to infectious disease. Some recombinant human granulocyte colony stimulating factors(rhG-CSFs) are in use to reduce the risk of this serious side effect. In this study, we examined the pharmacological properties of DA-3030, a rhG-CSF expressed in E. coli. DA-3030 100 and 1000 ㎍/㎏, i. v., had no significant effect on the central nervous, gastrointestinal system in mice and cardiovascular system in rabbits, but it slightly inhibited the spontaneous motility of isolated nonpregnant uterus in rats. It also had no influence on excretion of urinary electrolytes. DA-3030 administered for successive 3 days increased the blood WBC count in zymosan air pouch inflammed rats and in normal rats. These results indicate that DA-3030 has little side effects in animals.

고지방식이 섭취 마우스에서 간 중성지방 축적의 시간에 따른 변화 : 인슐린저항성 지표들과의 상관관계 분석

배은주(Eun Ju Bae) 대한약학회 2012 약학회지 Vol.56 No.6

Liver is the major organ to regulate the systemic glucose homeostasis and insulin resistance. Excess energy intake leads to triglyceride accumulation in adipose tissue first and subsequent accumulation in liver, resulting in obesity and type 2 diabetes. The representative pathological animal model for obesity associated insulin resistance is a high fat diet (HFD) fed mice model. Given the essential role of liver fat accumulation in developing systemic insulin resistance in obesity, I measured the liver triglyceride contents in HFD fed mice as a function of time. As such, in this report, I show the cause and effect relationship with regard to time during a HFD feeding between a variety of factors that are related to systemic insulin resistance including glucose intolerance, plasma insulin level and inflammatory gene expression in liver and adipose tissue.

무용 전공자와 비전공자의 감성지능 비교 연구

배은주(Eun Ju Bae),유병인(Byung In Yoo),이경훈(Kyung Hoon Lee) 한국체육철학회 2000 움직임의철학 : 한국체육철학회지 Vol.8 No.2

The purpose of this study was to show the influences that dancing education can affect female adolescents in their emotional development. Taking some high school students in dancing major and other major as sample survey, social influences and individual abilities were investigated. A 77-statement questionnaire(utilizing a 5-point Likert Scale) was designed for providing information about emotional intelligence. Frequency, Univariate, T-test and Anova were applied to analyze data by SAS package. The result can be summarized as follows: First, Hypothesis 1. There are differences between the people with major in dancing and the others in emotional intelligence. This hypothesis is accepted because it shows some important differences within 5% of attention level. As the result of T-test, it shows an important difference between the people majoring in dancing and not within 5% of attention level about sociality in personal relationship aspect, responsibility, self-control in social relationship, optimism and boldness in personal inner aspect, and achievement desire and creativity in achievement inclination relationship. Second, Hypothesis 2 There is a difference of emotional intelligence according to personal information factor of the person majoring in dancing. This hypothesis shows the important difference within 5% of attention level. This hypothesis is accepted by express important difference to emotional intelligence. According to the results of this study, it is possible to make the program of school education which meets students` needs. Therefore, there will be a positive development of emotional intelligence in dancing education.

Neonatal Onset Isovaleric Acidemia with Novel Mutation

김영한,배은주,박형두,이홍진,Kim, Young Han,Bae, Eun Ju,Park, Hyung-Doo,Lee, Hong Jin The Korean Society of Inherited Metabolic Disease 2016 대한유전성대사질환학회지 Vol.16 No.1

Isovaleric acidemia is autosomal-recessively inherited and an inborn error of metabolism caused by abnormal leucine metabolism due to the genetic defect of IVD (Isovaleryl-CoA dehydrogenase). IVD corresponds to mitochondrial matrix enzyme that acts on converting isovaleryl-CoA into 3-methylcrotonyl-CoA in the leucine catabolism. The IVD gene is located at Chromosome 15q14-q15, particularly between base pair 40,405,485 and base pair 40,435,948. It consists of 12 exons and has been reported to cause over 50 diseases so far. We conducted IVD gene test on the patient with acute isovaleric acidemia and confirmed a new type of mutation for the first time. As a result of analyzing the IVD gene sequence, we found out that c.129T>G(p.Asn43Lys) and c.1033A>G(p.Asn345Asp) mutations exist as heterozygosity at Exon 1 and Exon 10 respectively, novel mutation.

새로운 캅사이신 유도체 DA-5018 의 국소자극성에 관한 연구

김원배(Won Bae Kim),양중익(Junn Ick Yang),배은주(Eun Ju Bae),신명수(Myeong Soo Shin),김순회(Soon Hoe Kim),손문호(Moon Ho Son),김희기(Hee Kee Kim) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.2

Capsaicin cream has been used to attenuate the pain associated with diabetic neuropathy, rheumatoid arthritis, osteoarthritis and postherpetic neuralgia. But its common side effect, local irritation, limits the use of it and there is still a need for a new analgesic devoid of this side effect. This study was conducted to compare the local irritant effect of DA-5018, a new capsaicin derivative, with that of capsaicin in various animal models and human beings. Capsaicin, applied topically to the mouse ear, produced dose-dependent increase of ear volume and the frequency of ear scratching behavior in mice. Neither ear volume nor scratching behavior was affected by DA-5018. In eye wiping test of rat, DA-5018 was 10 times less irritant than capsaicin. Capsaicin administered intradermally into the rat paw elicited paw lick/lift response with a potency which was three times that of DA-5018. Zostrix-HP (0.075% capsaicin cream), but not DA-5018 0.3% cream, increased ear volume of rat and induced thermal hyperalgesia in normal and carrageenan inflamed paws. Six day-treatment of Zostrix-HP failed to develop tolerance against this thermal hyperalgesia. In human beings, Zostrix-HP produced burning sensation and itching in more than 90% of volunteers involved and its maximum irritant effect was significantly higher than that of DA-5018 cream. These results suggest that local irritation and burning sensation produced by DA-5018 is much less than capsaicin.

새로운 캅사이신 유도체 DA-5018 의 일반약리작용

김원배(Won Bae Kim),양중익(Junn Ick Yang),배은주(Eun Ju Bae),신명수(Myeong Soo Shin),김순회(Soon Hoe Kim),손문호(Moon Ho Son),김희기(Hee Kee Kim),차봉진(Bong Jin Cha) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.1

DA-5018(N-(3-(3,4-dimethylphenyl)propyl)-4-(2-aminoethoxy)-3-methoxyphenylacetamide) is a new capsaicin derivative under development as topical analgesic agent. The general pharmacological properties of DA-5018 on central nervous, cardiovascular, gastrointestinal and other organ systems were studied in experimental animals. DA-5018 cream (0.3%) had no effects on behavior, hexobarbital-induced sleeping time, body temperature, spontaneous activity, blood pressure, heart rate, intestinal charcoal propulsion, urine volume and electrolyte excretion even at a high dose of 2000 mg/kg in rats. In addition, DA-5018 cream had little skin irritation compared to Zostrix-HP (capsaicin, 0.075%) cream in rabbits. In isolated guinea pig tissue studies, DA-5018 increased the contractility of trachea and ileum and also increased sinus rate of atrium in a range of 10^(-8)-10^(-5) M, but its efficacy as a agonist was weak. These results suggest that DA-5018 cream might be used topically without serious side effects.

Isolated Glycerol Kinase Deficiency

이종윤,김희권,배은주,오필수,박원일,이홍진,Lee, Jong Yoon,Kim, Hui Kwon,Bae, Eun Ju,Oh, Phil Soo,Park, Won Il,Lee, Hong Jin The Korean Society of Inherited Metabolic Disease 2012 대한유전성대사질환학회지 Vol.12 No.1

3세된 환아가 응급실에 혼수와 복통을 주소로 전원되었다. 응급실에서 시행한 신체 진찰에서 drowsy한 정신상태를 나타내었으나 다른 신경학적 검사에서 특별한 이상 소견을 보이지는 않았다. 시행한 혈액 및 소변 검사에서 고글리세롤혈증(hyperglycerolemia), 케톤혈증(ketonemia) 및 케톤요증(ketonuria)이 있었다. 아침 첫 소변으로 시행한 소변 유기산 검사에서 현저한 고글리세롤요증이 발견되었으며, 암모니아의 상승, 음이온차의 상승, 전해질의 이상 등의 소견이 없어 단독성 GKD를 의심하였다. GK 유전자 검사를 시행한 결과 exon 11 주위 인트론에서 4염기가 삽입된 새로운 돌연변이를 확인하여 문헌고찰과 함께 보고하는 바이다. A 3-year-old boy was transferred to emergency room (ER) with lethargy and abdominal pain. Physical examination revealed drowsy mental status but neurologically intact. Basic evaluation in ER shows hypoglycemia (43 mg/dL), hyperglycerolemia, ketonemia and ketonuria. Initial urine organic acid was performed and the result showed severe hyperglyceroluria. Under suspicion of isolated GKD, GKD gene was obtained from his DNA from white blood cell in peripheral blood and sequencing was performed. Isolated glycerol kinase deficiency (GKD) is an X-linked inborn error of metabolism that is either symptomatic or asymptomatic. GKD is due to deletions of, or mutations within, the GK gene, and there is no genotype-phenotype correlation. Gene study that we performed showed normal at a well-known mutation site, but found 4-base insertion at 79 base pair away from the beginning of exon 11.

새로운 캅사이신유도체 DA-5018 의 피하주사 및 구소도포시 진통효과

김원배(Won Bae Kim),양중익(Junn Ick Yang),배은주(Eun Ju Bae),신명수(Myeong Soo Shin),손문호(Moon Ho Son),김희기(Hee Kee Kim),공재양(Jae Yang Kong) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.2

The analgesic effects of DA-5018, a new capsaicin derivative, were evaluated in various experimental pain models. Drugs were administered subcutaneously or topically. When drugs were administered subcutaneously, 1) the ED_(50) values of DA-5018, morphine ·HCl, capsaicin and acetaminophen were 0.091-2.0, 0.3-4.3, 1.4-26.5 and 45.4-643 mg/kg, respectively in various pain or inflammatory models including acetic acid writhing, formalin, tail flick, Randall-Selitto, hot plate and croton oil-induced ear edema test, 2) the AD₂ values (the dose for doubling of pain threshold of vehicle control) of DA-5018, capsaicin and ketoprofen were 1.07±0.18, 23.47±4.46 and 2.97±0.43 mg/kg in Freund`s complete adjuvant (FCA)-induced arthritic pain model. And by topical application, 1) neither DA-5018 0.3% cream nor Zostrio-HP (capsaicin 0.075%) were effective in formalin test, 2) although DA-5018 0.3% cream significantly inhibited the croton oil-induced ear edema being better than Zostrix-HP and Kenofen (ketoprofen 3%). 3) Ln FCA model, DA-5018 0.3% cream reversed the decreased pain threshold of arthritic rat from 136.4 g (day 0) to 289.0 g (day 5) and 250.1 g (day 10), which was similar to Zostrix-HP, These results suggest that DA-5018 administered subcutaneously has a potent and broad analgesic spectrum than nonsteroidal antiinflammatory drugs against acute and chronic pain, and by topical application it exerts comparable analgesic and antiinffammatory effects to capsaicin cream.

새로운 캅사이신 유도체 DA-5018 의 급성통증 모델에서의 진통작용

김원배(Won Bae Kim),양중익(Junn Ick Yang),배은주(Eun Ju Bae),신명수(Myeong Soo Shin),김순회(Soon Hoe Kim),손문호(Moon Ho Son),김희기(Hee Kee Kim),박노상(No Sang Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.1

Analgesic effect of DA-5018, a new capsaicin derivative, was evaluated in various rat models of experimentally induced acute pain. DA-5018(0.2∼10.0 ㎎/㎏, p.o.) prevented the writhing syndromes induced by acetic acid or phenyl-p-benzoquinone(PBQ). It increased the pain threshold of inflamed paw when tested by the Randall-Selitto method at the dose of 2.0∼20.0 ㎎/㎏ by oral administration. And also it showed antinociceptive activities in tail-pinch(1.0∼20.0 ㎎/㎏, p.o.) and tail-flick test(5.0∼50.0 ㎎/㎏, p.o.). The potency and efficacy of DA-5018 were comparable to morphine·HCl in all the models mentioned above. Acetaminophen exhibited the inhibition of acetic acid-induced writhing syndromes and also analgesic activity in Randall-Selitto test, but it showed the limited efficacy in tail-pinch and tail-flick test. These results mean that DA-5018 has a broader analgesic activity profile than acetaminophen. And we found out that the analgesic activity of DA-5018 was 100 times more potent when administered centrally than administered orally in tail-flick test. These results suggest that DA-5018 has an orally active analgesic activity, and central nervous system may be involved in the action of DA-5018.