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박호선 영남대학교 의과대학 2012 Yeungnam University Journal of Medicine Vol.29 No.1
Streptococcus pneumonia is a very important pathogen for children and elderly people. Two types of pneum- ococcal vaccines are available in the market: pneumococcal polysaccharide vaccine(PPSV) and pneumo- coccal conjugate vaccine(PCV). PPSVs have been used for more than 30 years, and PCVs for about 10 years. There have been many reports concerning the evaluation of the vaccines’ efficacies in preventing pneumo- coccal diseases such as meningitis, pneumonia, and otitis media and bacteremia, but the clinical trials had been performed with different conditions, such as diverse vaccine valencies, age groups, races, target out- comes, immunological cut-off values, and follow-up periods. PPSV is recommended for elderly people and chronic disease patients such as asthma, diabetes mellitus, chronic renal failure, and hyposplenic patients. According to the data from several systemic reviews and population-based surveillances, PPSV is effective for pneumococcal pneumonia and vaccine-type bacteremia among healthy adults. Until now, however, there is insufficient evidence of the effectiveness of PPSV among high-risk adults. PCV is very effective in preventing vaccine-type invasive pneumococcal disease(IPD) among children, but its efficacy for pneumonia is very low among children. The incidence of vaccine-related or non-vaccine-type IPDs is increasing after the introduction of 7-valent PCV(PCV7) as a routine immunization for children. Recently, 10- and 13-valent PCVs have been used for children, instead of PCV7. Therefore, continuous surveillance for serotype change among pneumococcal diseases is necessary to evaluate the vaccines’ efficacy.
Evaluation Methods for the Immunogenicity of Varicella and Zoster Vaccines
박호선 대한미생물학회 2013 Journal of Bacteriology and Virology Vol.43 No.4
Varicella vaccine has been included in the national immunization program for children since 2005 and zoster vaccine has been released since 2012 in Korea. Even though both varicella and zoster are caused by varicella-zoster virus (VZV), pathogeneses are different. In varicella, neutralizing antibody is very important to protect disease because VZV spreads via blood or lymph. In contrast, cell-mediated immunity is more important in zoster because of the neuronal spread of VZV. Therefore, the measurement methods of the immunogenicity against varicella and zoster vaccines are different. Fluorescent antibody to membrane antigen (FAMA) assay is the gold standard method to detect the protective antibody against VZV. It is still used as a reference test for the other methods. However, the fastidious nature required to perform the FAMA assay limits its use as a routine assay for the evaluation of vaccine immunogenicity. Nowadays, glycoprotein ELISA (gpEIA) is used as an alternative method for FAMA assay. However, there is no agreement over the protective level of gpEIA antibody titer with WHO standard international unit. The immunogenicity of zoster vaccine has been evaluated by responder cell frequency assay and IFN-γ ELISpot assay. Nevertheless, skin test is considered to be a more accurate biomarker for cell-mediated immunity against zoster. For the evaluation of varicella vaccine, it is necessary to standardize the FAMA assay and to set the cut-off value for the gpEIA antibody titer through long-term follow-up study. For zoster vaccine, the evaluation of cell-mediated immunity in Korean adults is urgently needed.
사람과 기니픽 세포주들에 대한 한탄바이러스의 감수성 및 증식
박호선,황규계,전복환,김혜숙,박송용 대한바이러스학회 1993 Journal of Bacteriology and Virology Vol.23 No.1
Hantaan virus(ROK-84-105) was propagated on various normal human diploid cell lines and guinea pig embryonic lung(GEL) cells. Viral antigens were detected by immunofluorescence assay in each cell lines snd immunoblotting pattern of viral proteins in these cells was identical with that of in Vero E6 cells. So, we found that Hantaan virus was susceptible to not only Vero E6 cells and A549 cell but also normal human diploid cell lines and GEL cells. Contiuous propagation of Hantaan virus in human diploid cell lines and GEL cells was possible and yield of the virus in human embryonic lung fibroblast(LuMA) was enough to rnake a vaccine.
Systemic Review for Efficacy of Human Papillomavirus Vaccines
박호선 대한미생물학회 2011 Journal of Bacteriology and Virology Vol.41 No.4
Two human papillomavirus (HPV) vaccines (Gardasil^®and Cevarix^(TM)) were launched between 2006~2007. Clinical trials have been performed in several countries. However, it takes few decades to measure HPV vaccine efficacy for the protection of cervical cancer. Therefore, several surrogate markers such as seroconversion rate, presence of HPV DNA,and cytological/ histological abnormalities have been evaluated. Until now, long-term follow-up data for 5 years (Gardasil) and for 8.4 years (Cevarix) were available from international trials. However, only seroconversion rate at 4weeks after vaccination and safety were evaluated in Korea. It is necessary to establish a reference laboratory and long-term follow-up monitoring system for the proper evaluation of HPV vaccines in Korea.