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      • KCI등재

        ISSUES WITH A CHAINED-TYPE PRICE INDEX: AN ANALYSIS WITH THE PRODUCER PRICE INDEX

        박철범,류덕현 중앙대학교 경제연구소 2011 Journal of Economic Development Vol.36 No.3

        Regarding the recent switch from the fixed base price index to the chained-type price index in many countries, we examine important issues including the selection of the weight to produce more accurate chained-type price indices and to maintain statistical consistency in the time series of a price index in this study. We determine that the actual weight from year t-3 data better produces a more correct chained-type producer price index at t between two available methods of selecting the weights. This weighting method also provides generally better statistical consistency and stability for the chained-type producer price index. We also compare the MAE and RMSE of the price equations of the fixed base and chain indices. Both the unit root test and comparison of the model performance evaluation reveal no critical difference, thus confirming a stability over the two indices. In particular, the substitutability of the chain index for the fixed base index is highly obtained, regardless of the time horizon. Overall, we can confidently assert that the chain index provides a statistical consistency and stability over a fixed base index.

      • KCI등재후보

        Genotoxicity Studies on Geranti Bio-Ge Yeast,an Organic Germanium Synthesized in Yeasts

        박철범,김윤배 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.1

        The objective of this study was to determine genotoxic potential of Geranti Bio-Ge YeastⓇ, an organic germanium naturally synthesized in yeasts. For the in vitro reverse mutation test, we set the treatment levels of Geranti Bio-Ge YeastⓇ at 312.5, 625, 1,250, 2,500 and 5,000 ㎍/plate using Salmonella typhimurium strains (TA1535, TA1537, TA98 and TA100) and Escherichia coli WP2uvrA (pKM101). No significant mutagenic activity was observed both in the presence and absence of S9 mix with all Salmonella and Escherichia strains used. For the in vitro chromosomal aberration test using Chinese hamster lung fibroblasts, we set the treatment levels of Geranti Bio-Ge Yeast® at 1,250, 2,500 and 5,000 ㎍/㎖, No significant increase in the structural and numerical chromosome aberration was observed in both the presence and absence of S9 mix. In the micronucleus test, mice were orally administered with 125, 250, 500, 1,000, 2,000 or 5,000 ㎎/㎏ of Geranti Bio-Ge Yeast®, or intraperitoneally with mitomycin C as a positive control. The mice were sacrificed 24 hours later, and bone marrow was collected and stained with Giemsa solution. There was no evidence that Geranti Bio-Ge Yeast® significantly induced micronucleated polychromatic erythrocytes. In conclusion, it is suggested that Geranti Bio-Ge Yeast® do not have a genotoxic potential under the conditions of this study. 목차

      • KCI등재

        Demographic Structure and Financial Markets in Korea

        박철범,김동헌 한국경제연구학회 2012 Korea and the World Economy Vol.13 No.2

        This paper examines the relationship between the demographic structure and asset prices in Korea based on the standard life-cycle model. To this end, this paper employs a non-parametric model which has an advantage of no functional form for the relationship a priori. We find that the estimated relation between the real interest rate and population density function is consistent with the implication from life-cycle models, whereas the relation between the normalized stock price and population density function is not. The projection based on the projected population estimates indicates that the real interest rate is going to rise until the 2020 due to the increase trend of old consumers and their dissaving behavior after the retirement.

      • Asset Prices, Heterogeneous Expectations, and Limited Short Sales

        박철범 고려대학교 미래성장연구원 2016 미래성장연구 Vol.2 No.1

        This paper extends the Harrison-Kreps model by allowing limited short sales and finite wealth. The main results of this paper are: (1) investors always pursue short-term gains (or participate in single-period speculation) when perceiving heterogeneous expectations; (2) important properties of the equilibrium price in the Harrison-Kreps model still hold even when limited short sales and finite wealth are allowed; (3) an increase in short-sale costs raises the risky asset price; and (4) an increase in the dispersion of expectations about future dividends also raises the risky asset price when the risky asset is held by a minority of investors.

      • KCI등재

        Various Expression of p63 in Ameloblastomas

        박철범,박경주,이종헌 대한구강악안면병리학회 2012 대한구강악안면병리학회지 Vol.36 No.3

        Several recent studies have detected genetic and cytogenetic alterations in epithelial odontogenic tumors. However, the detailed mechanisms of oncogenesis, cytodifferention, and tumor progression remain unknown. p63 as p53 homolog gene has been identified at loci 3q27-29. The p53 signaling cascade has an important role in oncogenesis or cyto- differentiation of odontogenic epithelium. Recently, several syndromes associated with p63 gene mutations have shown to include various tooth abnormalities of both the primary and permanent dentition. But little is known about p63 expression in odontogenic tumors, especially ameloblastomas. The purpose of this study were to examine various expression of p63 in ameloblastomas by immunohistochemistry and to clarify the possible biological role of p63 in ameloblastomas. 15 specimens including 6 follicular, 4 plexiform, 3 acanthomatous, and 2 granular cell types were fixed in 10% neutral formalin. 4um thick sections were used for routine H&E and immunohistochemical examinations. After immuno-histochemical satining, they were examined at a final magnification of 400X. For each case a minimum of 1000 nuclei located in the central and peripheral layers were counted in up to 10 consecutive microscopic fields per case. The immunoreactive cells were evaluated semiquantitatively. Immunoreactivity for p63 in all the types of ameloblastomas was higher in peripheral neoplastic cells than in central neoplastic cells. Keratinizing cells in acanthomatous ameloblastoma and granular cells in granular cell ameloblastoma showed markedly decreased reactivity for p63 in acanthomatous and granular cell ameloblastoma. Labelling index of acanthomatous,plexiform, and granular cell type was 86±11%, 81±17% and 83±15% in peripheral area while 88±14%, 82±11% and 76±10% in central area, respectively. Labelling index of follicular type was 17±4% in peripheral area while 21±3% in central area. There was no significant relationship between plexiform, acanthomaous, and granular cell type, while significant relationships between follicular and acanthomatous type, between plexiform and follicular type, and between granular cell and follicular type, respectively. It suggested that p63 expression could paly an important role in the pathogenesis of ameloblastomas. Morever plexiform, acanthomatous,and granular cell type would show more aggressive proliferative potentiality than follicular type.

      • SCOPUSKCI등재

        Diethyl maleate가 N-methyl-N'-nitro-N-nitrosoguanidine에 의해서 유발되는 랫드 위암 발생에 미치는 영향에 관한 병리학적 연구

        박철범,이준섭,Park, Cheol-bom,Lee, Joon-sup 대한수의학회 1995 大韓獸醫學會誌 Vol.35 No.4

        This study was carried out to investigate the effects of diethyl maleate(DEM) on the carcinogenesis of forestomach and pyloric glandular stomach in rats caused by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG). A total of 60 male 6-week-old Wistar rats were given twice intragastric injection of MMNG(200mg/kg BW), then were given diets containing 5% NaCl for 3 weeks until 4th week of the experiment. And then the animals of groups of 1 and 2 were placed on diets containing 0.2% DEM for 16 weeks until the end of 20 weeks of the experiment. On the other hand, the animals of groups of 3 and 4 were placed on basal diets for the same periods. The tissues of forestomach and liver of each group were frozen in liquid nitrogen and the activities of quinone reductase(QR) were determined by measurement of the dicoumarol-sensitive reduction of dichloro-indophenol by NADPH at 600nm. All rats were sacrificed at the end of 20 weeks of the experiment. Every animal was fasted for 24 hrs prior to sacrifice. The forestomach was fixed in 10% neutral phosphate buffered formalin for histology and the pyloric gland was fixed in sublimated formalin for immunohistochemistry of pepsinogen 1 altered pyloric gland(PAPG). The final body weight of the group given MNNG and treated with 5% NaCI and DEM was significantly decreased compared with that of the group 4(p<0.05). Food and water consumption rates were not significantly changed. The preneoplastic and neoplastic lesions of the forestomach given MNNG and treated with 5% NaCI and DEM were significantly increased compared to those of the group 4(p<0.0l). The incidence of PAPG in the groups treated with 0.2% DEM was significantly increased compared with that of the group 4(group 1:p<0.01, group 2:p<0.05). The activities of QR of forestomach in the groups treated with 0.2% DEM were significanitly increased compared with those of the group 4(p<0.001), but those of liver were not significant. These results indicate that DEM exert the enhancing effect of forestomach and glandular stomach carcinogenesis in rats pretreated with MNNG and NaCl.

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