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Isoflavone-Free 검은콩펩타이드의 항고혈압 및 ACE 활성 억제효과
안창원(Chang-Won Ahn),신동석(Dong-Seok Shin),박수현(Soo-Hyun Park),홍순선(Soon-Sun Hong),강주희(Ju-Hee Kang),박창신(Chang-Shin Park) 대한약학회 2012 약학회지 Vol.56 No.5
Antiobesity, hypotriglyceridemic and antihypertensive activities of isoflavone-free peptide mixture (black soybean peptide, BSP) were reported in our previous experiments. In the present study, angiotensin converting enzyme inhibitory (ACEi) activity was decreased in the aorta tissues of spontaneously hypertensive rats (SHRs) treated with BSP (1% in drink water) for 4 weeks, but not in serum. BSP administration significantly decreased ACE activity by 17.5% (from 33.2±4.5 to 27.4±1.96 mUnit/mg, p=0.0013) in aorta tissue hydrolysate. BSP treatment also decreased significantly mean blood pressure (BP) (from 213.0±16.96 to 184.0±6.53 mmHg, p<0.0001) as expected. These results indicate that BSP has antihypertensive activity as well as ACEi activity.
Heme 산화효소 발현 유도체로서 Isoflavone-Free 검은콩 펩타이드의 항고혈압 활성
신미경(Mi-Kyung Shin),권용현(Yong-Hyun Kwon),안창원(Chang-Won Ahn),신동석(Dong-Seok Shin),박수현(Soo-Hyun Park),최보화(Bo-Hwa Choi),홍순선(Soon-Sun Hong),강주희(Ju-Hee Kang),박창신(Chang-Shin Park) 대한약학회 2012 약학회지 Vol.56 No.3
We previously reported that the novel isoflavone-free peptide mixture (black soybean peptide, BSP) had several beneficial effects like antiobesity and hypotriglyceridemic effect. However, there are no reports for BSP on anti-hypertensive activity. BSP induced heme oxygenase-1 (HO-1) in HUVECs, thus investigated the HO-1-induced activity in HUVECs and the anti-hypertensive effects in SHR animal model. BSP significantly induced HO-1 expression both at transcriptional and protein levels in a time- and dose-dependent manner as measured by RT-PCR and Western blot analysis, respectively. These inductions were abolished by pretreatment of N-acetyl-cystein (NAC, 1~10 mM), but not by employing Tempol, a superoxide dismutase (SOD) mimetic (1~5 mM). As expected, enzymatic activity (~2 fold) determined by bilirubin formation assay and cGMP concentration (~6 fold) were significantly increased in BSP-treated cells. Based on the numerous evidences on the beneficial effects of HO-1 and our results, we investigated in vivo effects of BSP on the antihypertensive activity. The administration of BSP (1% in drinking water) significantly decreased mean blood pressure (BP) (from 218.6±6.99 to 190.0±3.42 mm Hg, p<0.01). This result indicates that BSP is strong inducer of HO-1 expression, which may be triggered by oxidative stress, and has anti-hypertensive activity.
김지현,박창신,함대현,이혜정,심인섭,Kim, Ji-Hyun,Park, Chang-Shin,Hahm, Dae-Hyun,Lee, Hye-Jung,Shim, In-Sop 대한약침학회 2004 Journal of pharmacopuncture Vol.7 No.1
Acupuncture has fairly good weight-reducing effect in treating simple obesity due to the neuroendocrine regulation. In this study, the antiobesity effects of herbal acupuncture(HA) with Sang-hwang(phellinus linteus) at Fuai(SP16) were investigated in the rat fed on high-fat(HF) diet. Sang-hwang mushroom has been proven to have anti-carcinogenic effects and Sang-hwang extracts are highly effective in treatment and preventive treatment of AIDS, diabetes and high blood-pressure. To determine whether the Sang-hwang herbal acupuncture may have the anti-obesity effect, male Sprague-Dawley(4-wk-old) rats were fed a HF diet for 5 wk, which produced significant weight gain compared to rats were fed a normal diet, and then herbal acupuncture were treated for 3 wk in HF diet group. The body weight, food consumption, food effeciency ratio(FER), body fat mass, plasma nitric oxide(NO) were investigated in rats fed on normal diet, HF diet, and HF diet with HA(HF-diet-HA) groups. NO has been proposed to be involved in the regulation of food intake. In addition, the expression of appetite peptides such as orexigenic peptide neuropeptide Y(NPY) and the anorectic peptide cholecystokinin(CCK) were observed in the hypothalamus. HF-HA group reduced body weight gain, FER, body fat contents and NO concentration compared to HF diet group. The expression of NPY was reduced in arcuate nucleus(ARC), and CCK was increased in the paraventricular nucleus(PVN) after treatment of HA. In conclusion, Sang-hwang HA reduced adipocity, plasma NO and hypothalamic NPY, but increased CCK expression in the HF dietinduced obesity rat, therefore HA may have anti-obesity action through regulating body weight and appetite peptide of the central nervous system.
온라인 뉴스이용에 관한 연구: 조선닷컴 뉴스의 연성화 및 제목 선정성과 조회수간의 상관관계
최영 ( Young Choi ),박창신 ( Chang Shin Park ) 한국커뮤니케이션학회 2009 커뮤니케이션학연구 Vol.17 No.1
이 연구의 목적은 인터넷 뉴스에서의 연성화 및 선정성 경향을 알아보고, 이러한 추세가 이용자의 뉴스 이용과 소비에 어떤 영향을 미치는 지를 살펴보는 것이었다. 분석결과, 우선 연성뉴스가 전체 분석기사의 과반수 이상을 차지하고 있는 것으로 나타났으나 선정적 제목을 단 기사는 많지 않은 것으로 드러났다. 연성화 정도 및 제목의 선정성과 기사 특성간의 관계 검증에서는 대체적으로 통계적 유의미한 관계가 있는 것으로 나타났다. 마지막으로 조회수와 연성화 정도, 제목의 선정성 및 기사의 특성 등과의 관계에서는 기사주제를 제외하고는 모두 조회수와 관계가 있는 것으로 드러났다. 종합하면 이 연구의 분석대상이 된 온라인 서비스에는 분명 연성화 경향이 존재하지만 그 정도가 아주 심한 것은 아닌 것으로 조사되었고, 이러한 기사의 연성화 경향은 뉴스 조회수에 어느 정도 영향을 미치고 있는 것으로 드러났다. 한편 선정적 제목을 단 기사는 많지 않아 제목의 선정성 정도는 심하지 않은 것으로 나타났다. 그럼에도 불구하고 제목의 선정성은 기사 조회수에는 많은 영향을 미치고 있는 것으로 사료된다. The goal of this study is to examine how far and how deep soft journalism practices have extended into online journalism in Korea. It investigates the relationship between soft journalism practices and the exposure of news, which until now has seldom been the object of empirical research. There has been little actual measurement to determine how much soft journalism influences everyday online journalism practice. Specifically, this study investigates the level of soft journalism practice in online newspaper by analyzing the ratio of hard news vs soft news and the level of sensationaization of news headline, and then examines the relationship between soft journalism practices and news exposure. The results of the analysis of the log data files for actual online news users reveal that there is a statistically significant relationship between soft journalism practice and news exposure, especially in the case of headline sensationalization and the number of clicks.
온라인 뉴스의 제목달기 분석: 네이버 뉴스캐스트의 헤드라인 특성을 중심으로
최영 ( Young Choi ),박창신 ( Chang Shin Park ),고민경 ( Min Kyung Ko ) 한국커뮤니케이션학회 2010 커뮤니케이션학연구 Vol.18 No.1
본 논문은 네이버 뉴스캐스트를 통해 확인할 수 있는 `온라인 뉴스제목 달기`의 실태를 분석함으로써 우리나라 온라인 저널리즘의 속성을 파악하려는 문제의식에서 출발했다. 이를 위해 뉴스의 제목을 분석대상으로 하여 전통적 저널리즘에서 `올바른 제목달기`의 기본 원칙이 `뉴스 헤드라인 포털`의 성격을 가지는 뉴스캐스트에서 어느 정도 지켜지는 지를 분석했으며, 그 결과 제목의 선정성 경쟁이 어떤 이유에서 어떤 방식으로 이뤄지는지를 알아내고자 했다. 분석 결과 뉴스캐스트로 살펴 본 온라인 뉴스 서비스에서는 전통적인 제목 저널리즘의 가치가 상당히 훼손되거나 지켜지지 않았다. 네이버 뉴스캐스트 분석에서 확인한 `뉴스의 제목 달기`의 속성은 크게 다음의 3가지로 요약된다. 첫째, 헤드라인은 정보의 전달 만큼 네티즌 독자의 관심을 끄는 목적으로 작성되었다. 둘째, 헤드라인으로 전하고자 하는 메시지의 명료성과 헤드라인의 문법적 완결성은 뉴스캐스트에서 그다지 중요하게 취급되지 않는다. 셋째, 위의 두 가지 속성에 덧붙여 편집자가 제목을 보다 눈에 띄게 하는 방안으로 선정적인 제목을 다는 경우가 빈번하다. The goal of this study is to examine the headlines in the Newscast service of Naver, the most influential news portal service in Korea, in terms of functions and the level of sensationalism. It is safe to say that the headlines of Newscast are messages by themselves and have an impact on cognitive consciousness of reader. One composite week in July 2009 was constructed and used for the analysis. The data included 1,951 headlines. The results of this study revealed that the headlines were often utilizing for `fishing` (drawing user`s attention) rather than delivering or summarizing information of the main news articles. Approximately a half of the headlines in this study didn`t provide any information about news themselves. And in many cases headlines were not grammatically correct. It is also found that the guideline of editing headlines, which korean editors association calls `the rule of independent headlines`, were frequently ignored in this study. Finally, the level of sensationalism of the headlines in the Newscast was high as we expected and remained a strong force in the Newscast service for catching reader`s eyes.