타당성 평가가 보완된 모델 운용상의 전투실험 모의분석 절차 연구

박진우,김능진,강성진,서혁,Park, Jin-Woo,Kim, Nung-Jin,Kang, Sung-Jin,Soo, Hyuk 한국시뮬레이션학회 2010 한국시뮬레이션학회 논문지 Vol.19 No.4

Currently, our society has been changed from the industrial society to the information society. As the war progresses to Information Warfare, Network-Centric Warfare, Long-Range Precision Engagement and Robot Warfare, the military should advance to High-tech Scientific force. For this creation of the war potential, it is regarded as the warfighting experiment is a critical method. Surely it is rational that LVC(Live Virtual Constructive simulation) is desirable to make the warfighting experiment. But because it is limited by the cost, the time, the place and the resource, the constructive simulation(M&S : Modeling&Simulation) is a good tool to solve those problems. There are some studies about the evaluation process for developing the model, but it is unsatisfying in the process of the constructive simulations' operation. This study focuses on the way of constructive simulation operation, which is supplied with the evaluation process(VV&A : Verification Validation & Accreditation). We introduce the example of the rear area operation simulation for "appropriateness evaluation to the organization of logistic corps" by the AWAM(Army Weapon Analysis Model). This study presents the effective methods of the constructive simulations, which is based on the reliable evaluation process, so it will contribute to the warfighting experiments.

산화물 혼합상이 페라이트계 P/M스테인리스강의 고온산화 및 전기저항 안정성에 미치는 영향

박진우,고병현,정우영,박동규,안인섭,Park, Jin-Woo,Ko, Byung-Hyun,Jung, Woo-young,Park, Dong-Kyu,Ahn, In-Shup 한국분말야금학회 2016 한국분말재료학회지 (KPMI) Vol.23 No.3

In order to improve the high-temperature oxidation stability, sintered 434L stainless steel is studied, focusing on the effect of the addition of metallic oxides to form stable oxide films on the inner particle surface. The green compacts of Fecralloy powder or amorphous silica are added on STS434L and oxidized at $950^{\circ}C$ up to 210 h. The weight change ratio of 434L with amorphous silica is higher than that of 434L mixed with Fecralloy, and the weight increase follows a parabolic law, which implies that the oxide film grows according to oxide diffusion through the densely formed oxide film. In the case of 434L mixed with Fecralloy, the elements in the matrix diffuse through the grain boundaries and form $Al_2O_3$ and Fe-Cr oxides. Stable high temperature corrosion resistance and electrical resistivity are obtained for STS434L mixed with Fecralloy.

P/M Fecralloy의 성형성 및 전기저항특성 향상에 관한 연구

박진우,고병현,정우영,박동규,안인섭,Park, Jin-Woo,Ko, Byung-Hyun,Jung, Woo-Young,Park, Dong-Kyu,Ahn, In-Shup 한국분말야금학회 2016 한국분말재료학회지 (KPMI) Vol.23 No.6

The Fe-Cr-Al alloy system shows an excellent heat resistance because of the formation of an $Al_2O_3$ film on the metal surface in an oxidizing atmosphere at high temperatures up to $1400^{\circ}C$. The Fecralloy needs an additive that can act as a binder because of its bad compactability. In this study, the green compacts of STS434L and Al powder added to Fecralloy are oxidized at $950^{\circ}C$ for up to 210 h. Fecralloy and Al is mixed by two types of ball milling. One is vented to air and the other was performed in a sealed jar. In the case of Al addition, there are no significant changes in the electrical resistance. Before the oxidation test, Al oxides are present in the Fecralloy surface, as determined from the energy dispersive spectroscopy results. The addition of Al improves the compactability because of an increased density, and the addition of STS434L increases the electrical resistivity by forming a composite oxide.

P/M Fecralloy 성형체의 고온산화 및 전기저항 안정성에 미치는 SiO₂ 첨가 효과

박진우,옥진욱,정우영,박동규,안인섭,Park, Jin-Woo,Ok, Jin-Uk,Jung, Woo-young,Park, Dong-kyu,Ahn, In-Shup 한국분말야금학회 2017 한국분말재료학회지 (KPMI) Vol.24 No.4

A metallic oxide layer of a heat-resistant element contributes to the high-temperature oxidation resistance by delaying the oxidation and has a positive effect on the increase in electrical resistivity. In this study, green compacts of Fecralloy powder mixed with amorphous and crystalline silica are oxidized at $950^{\circ}C$ for up to 210 h in order to evaluate the effect of metal oxide on the oxidation and electrical resistivity. The weight change ratio increases as per a parabolic law, and the increase is larger than that observed for Fecralloy owing to the formation of Fe-Si, Fe-Cr composite oxide, and $Al_2O_3$ upon the addition of Si oxide. Si oxides promote the formation of $Al_2O_3$ and Cr oxide at the grain boundary, and obstruct neck formation and the growth of Fecralloy particles to ensure stable electrical resistivity.

자주식 휠체어 접근성 실태에 기반한 대학 건물 3차원 접근성맵 제작 - 충북대학교 사례를 중심으로 -

박진우,이예지,이현정,Park, Jin Woo,Lee, Ye Ji,Lee, Hyun-Jeong 인천대학교 도시과학연구원 2021 도시과학 Vol.10 No.1

The purpose of this study was to evaluate accessibility condition of buildings in a college from manual wheel chair users' perspective in order to suggest improvements, and to develop 3D accessibility maps in order to assist manual wheelchair users' prior planning for the building use. In May 2020, on-site investigation was held to three buildings in Chungbuk National University. Major findings were as follows. (1) There were some building entrances that showed level difference over 2cm without proper ramp with slow slope 1/8 or less. (2) Some rooms were found to have accessibility issues to have floors with height more than 2cm, and/or to have no height-adjustable desks. (3) Although accessible restrooms were in good condition for manual wheelchair users' access and use, it is suggested to install accessible restroom for each gender in each floor for better access. Using the study results, 2-dimensional accessibility maps for each floor were developed in color and grayscale, which were further developed into 3-dimensional accessibility maps for each building.

한국 선물시장에서의 Circuit Breakers 제도의 효용성에 관한 실증연구

박진우,정순길 ( Jin Woo Park,Soon Gil Jung ) 한국파생상품학회 1998 선물연구 Vol.6 No.1

본 연구에서는 Circuit Breakers제도가 우리나라 주가지수선물시장에서 본래의 목적에 부합하는 기능을 하고 있는 지를 실증분석하였다. 이를 위하여 선물의 가격제한폭파 Circuit Breakers발동요건이 동일했던 기간(`기간1`)과 가격제한폭이 Circuit Breakers발동요건보다 컸던 기간(`기간2`)으로 나누어 분석하고 있다. 우리나라 선물시장의 Circuit Breakers는 대체로 두 기간 모두 선물가격이 현물가격에 비해 과민하게 반응하고 있는 상태에서 발동되고 있으나, 이렇게 발동된 Circuit Breakers가 가격안정화 기능을 제대로 하고 있는가에 대해서는 회의적인 결과를 보여주고 있다. 기간1의 경우에는 Circuit Breakers가 종료된 시점에도 선물가격은 거래체결 없이 발동직전에 제한폭에 이른 가격을 그대로 유지하는 경우가 대부분이었고, 기간2의 경우에는 Circuit Breakers종료 이후에도 전일종가 대비 선물가격 변화율의 절대값이 현물가격의 그것에 비해 높은 수준을 그대로 유지하고 있어 이상과열된 선물가격이 안정되지 못하고 있음을 보여주고 있다. Circuit Breakers가 변동성에 미치는 영향에 관해서는 Circuit Breakers종료후 정상적인 선물거래가 이루어지지 않는 기간1을 제외하고 기간2에 한정된 분석에서 Circuit Breakers가 선물가격의 변동성을 감소시키고 있는 반면, 현물가격의 변동성은 Circuit Breakers 발동전, 발동기간중, 종료후가 모두 비슷한 수준이었다. 끝으로 Circuit Breakers와 선물의 유동성에 관한 분석에서는 특히 기간1의 Circuit Breakers 발동일의 평균 선물거래량이 정상일의 거래량의 반 정도에 그치고 있어 Circuit Breakers발동이 선물의 유동성을 크게 제약했음을 알 수 있다. 그러나 선물의 가격제한폭이 Circuit Breakers발동요건보다 컸던 기간2에는 Circuit Breathers발동이 선물의 유동성을 제약하고 있지 않은 것으로 나타났다.

갑상선 종양의 발병 기전

박진우,Jin-Woo Park 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.2

Thyroid tumors display an intriguing biological diversity from benign follicular adenomas to lethal anaplastic carcinomas. Thyroid tumorigenesis is becoming better understood. Benign follicular adenomas are frequently associated with mutation of the thyrotrophin receptor, G alpha s or RAS. Although confirmatory studies are necessary, the present knowledge concerning the similarity in gene expression profiling between follicular adenomas and follicular carcinomas supports the progression of adenoma to carcinoma sequence. Four major genetic aberrations in follicular cell- derived thyroid carcinomas such as papillary, follicular, and Hurthle cell carcinomas include mutations of BRAF or RAS, and chromosomal rearrangement of RET/papillary thyroid tumor or PAX8/peroxisome proliferator-activated receptor gamma. Differentiated thyroid carcinomas of follicular cell origin dedifferentate to poorly differentiated or anaplastic thyroid carcinomas through mutation of p53 and CTNNB1. Familial nonmedullary thyroid carcinomas are heterogenous in genetic profiling, but some genes have been investigated as candidates for causative genetic aberration. Ret mutations can cause medullary thyroid carcinomas. A genotype-phenotype relationship helps to decide prophylactic thyroidectomiesin family members of hereditary medullary carcinomas such as MENIIa or MENIIb. Primary thyroid lymphomasare closely related with Hashimoto's thyroiditis. Recent novel and promising findings include additional abnormalities in the regulation of microRNA expression, polymorphisms associated with thyroid cancer susceptibility and epigenetic changes. A newly proposed fetal cell carcinogenesis hypothesis explains more about thyroid tumorigenesis than classical multi-step carcinogenesis model, but is not yet firmly supported by evidence. Future studies need to uncover new molecular mechanisms in thyroid tumorigenesis and to provide novel therapeutic targets for thyroid carcinomas. (Korean J Endocrine Surg 2010;10:79-87)

Cellular activities of osteoblast-like cells on alkali-treated titanium surface

박진우,이덕혜,여신일,박광범,최석규,서조영,Park, Jin-Woo,Lee, Deog-Hye,Yeo, Shin-Il,Park, Kwang-Bum,Choi, Seok-Kyu,Suh, Jo-Young The Korean Academy of Periodontoloy 2007 Journal of Periodontal & Implant Science Vol.37 No.2

임플란트와 골 사이의 결합력을 증가시키기 위하여 타이타늄 표면에 변화를 주기위한 많은 연구들이 진행되고 있다. 타이타늄의 표면 구조나 미세 지지도의 변화가 임플란트에 대한 세포의 반응에 영향을 미치며, 골아 유사세포는 표면 조도가 높은 타이타늄 표면에 더 잘 부착하며, 세포외 기질의 합성과 광물화 결정이 더 잘 일어난다고 알려져 있다. 그러나 대부분의 연구들은 마이크로 단위의 미세 지지도에 대한 연구들이고 나노 단위의 미세 지지도에 대한 연구들은 미미하다. 이에 본 연구에서는 ROS 17/2.8 cell line을 이용하여 기계적 처리만한 군을 대조군으로 하여 blasting 처리한 마이크로 단위의 미세 지지도 표면과 알칼리 처리된 나노 단위의 미세 지지도 표면에 대한 골아 유사세포의 세포 부착양상, 증식 그리고 골아 유사세포의 표식인자 발현양상 등을 상호 비교하여 골아 유사세포에 미치는 영향을 관찰하고자 하였다. SEM을 이용한 미세 지지도 관찰에서 알칼리 처리군에서는 약 200mm의 초미세 다공성의 양상을 나타내었고, blasting 처리한 군에서는 $10\;{\mu}m$ 이하의 움푹 파인 양상을 보였다. 표면조도 측정에 있어서는 blasting 처리한 군에서 기계적 처리와 알칼리 처리된 군보다 더 높은 표면 조도를 보였으며 이는 통계학적으로 유의한 차이를 나타내었다 (p<0.01). 표면결정성 분석에서는 알칼리처리 군에서 anatase와 rutile결정형이 보였으나, blasting 처리한 군과 기계적 처리 군에서는 관찰되지 않았다. 골아 유사세포 1시간 배양 후의 전자현미경 관찰에서 모든 군의 세포는 부착 및 전개 과정을 보였고, 3시간 배양에서는 모든 군의 세포가 더 많이 전개되었으나, blasting 처리한 군과 알칼리처리 군에서 세포가 다소 더 불규칙한 형태를 나타내었다. 24시간 배양에서는 모든 군의 세포에서 완전히 전개가 일어난 양상을 보였다. 1, 4, 7일간 세포배양 후 세포활성을 평가하기 위한 MTT assay에서는 모든 군에서 시간이 증가함에 따라 세포수가 증가하였으며, 1일째에 blasting 처리한 군과 알칼리처리 군에서 기계적 처리 군에 비해 세포활성도가 통계학적으로 유의한 증가를 보였다(p<0.01). 골아 유사세포 표식인자인 osteopontin, alkaline phosphatase, ${\alpha}\;1(1)$ collagen의 유전자 발현양상을 관찰해 본 결과, osteopontin, alkaline phosphatase, ${\alpha}\;1(1)$ collagen의 유전자 발현양상이 세 군 모두에서 유의한 차이는 관찰할 수 없었으나, blasting 처리한 군과 알칼리처리 군에서 기계적 처리 군에 비해 유전자 발현양상이 다소 증가하는 경향을 보였다. 결론적으로 blasting 처리한 마이크로 단위의 미세 지지도 표면과 알칼리 처리된 나노 단위의 미세 지지도 표면이 기계적 처리 군에 비해 골아 유사세포의 기능을 촉진시키나, 알칼리 처리된 나노 단위의 미세 지지도 표면은 blasting 처리한 마이크로 단위의 미세 지지도 표면이 골아 유사세포의 기능에 미치는 영향을 압도하지는 않는 것으로 사료된다. To improve osseointegration at the boneto-implant interface, several studies have been carried out to modify titanium surface. Variations in surface texture or microtopography may affect the cellular response to an implant. Osteoblast-like cells attach more readily to a rougher titanium surface, and synthesis of extracellular matrix and subsequent mineralization were found to be enhanced on rough or porous coated titanium. However, regarding the effect of roughened surface by physical and mechanical methods, most studies carried out on the reactions of cells to micrometric topography, little work has been performed on the reaction of cells to nanotopography. The purpose of this study was to examme the response of osteoblast-like cell cultured on blasted surfaces and alkali treated surfaces, and to evaluate the influence of surface texture or submicro-scaled surface topography on the cell attachment, cell proliferation and the gene expression of osteoblastic phenotype using ROS 17/2.8 cell lines. In scanning electron micrographs, the blasted, alkali treated and machined surfaces demonstrated microscopic differences in the surface topography. The specimens of alkali treatment had a submicro-scaled porous sur-face with pore size about 200 nm. The blasted surfaces showed irregularities in morphology with small(<10 ${\mu}m$) depression and indentation among flatter-appearing areas of various sizes. Based on profilometry, the blasted surfaces was significantly rougher than the machined and the alkali treated surfaces (p<O.01). On the x-ray diffraction analysis, anatase and rutile($TiO_2$) were observed on alkali treated surfaces, whereas not observed on machined and blasted surfaces. The attachment morphology of cells according to time was observed by the scanning electron microscope. After 1 hour incubation, the cells were in the process of adhesion and spreading on the prepared surfaces. After 3 hours, the cells on all prepared surfaces were further spreaded and flattened, however on the blasted and alkali treated surfaces, the cells exhibited slightly irregular shapes and some gaps or spaces were seen. After 24 hours incubation, most cells of the all groups had a flattened and polygonal shape, but the cells were more spreaded on the machined surfaces than the blasted and alkali treated surfaces. The MTT assay indicated the increase on machined, alkali treated and blasted surfaces according to time, and the alkali treated and blasted surfaces showed significantly increased in optical density comparing with machined surfaces at 1 day (p<0.01). Gene expression study showed that mRNA expression level of ${\alpha}\;1(I)$ collagen, alkaline phosphatase and osteopontin of the osteoblast-like cells showed a tendency to be higher on blasted and alkali treated surfaces than on the machined surfaces, although no siginificant difference in the mRNA expression level of ${\alpha}\;1(I)$ collagen, alkaline phosphatase and osteopontin was observed among all groups. In conclusion, we suggest that submicroscaled surfaces on osteoblast-like cell response do not over-ride the one of the surface with micro-scaled topography produced by blasting method, although the microscaled and submicro-scaled surfaces can accelerate osteogenic cell attachment and function compared with the machined surfaces.

갑상선암 세포주에서 Troglitazone에 의한 TRAIL-유도 세포소멸 감수성의 증가

박진우,OrloH.Clark<SUP>1<.SUP>.Jin-Woo Park and Orlo H. Clark<SUP>1<.SUP> 대한갑상선-내분비외과학회 2003 The Koreran journal of Endocrine Surgery Vol.3 No.2

Purpose: Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induces apoptosis in many human cancer cells but not in normal cells. Thyroid cancer cells, however, appear to be relatively resistant to TRAIL-induced apoptosis. We investigated the effect of troglitazone, a PPARγ agonist, on TRAIL-induced apoptosis in thyroid cancer cells. Methods: We used 6 thyroid cancer cell lines: TPC-1, FTC- 133, FTC-236, FTC-238, XTC-1, and ARO82-1. We used flow cytometry to detect apoptosis and used MTT assay to measure anti-proliferation effects. ANOVA was used for statistical analysis. Results: TPC-1 cells were the most sensitive to soluble TRAIL. FTC-133 and ARO82-1 were resistant to TRAIL and growth inhibition was less than 20% at concentration of 800 ng/ml of TRAIL. In both TPC-1 (TRAIL-sensitive) and FTC- 133 (TRAIL-resistant) thyroid cancer cell lines, pretreatment with troglitazone enhanced TRAIL-induced cell death significantly. Bcl-family proteins did not seem to be involved in sensitization of TRAIL-induced apoptosis by troglitazone. Conclusion: TRAIL in combination with troglitazone induces apoptosis in thyroid cancer cells at suboptimal concentrations that can not be achieved using TRAIL alone. (Korean J Endocrine Surg 2003;3:113-120)

무인 항공기 탑재용 Ku대역 안테나에 관한 연구

박진우,류지호,Park, Jin-Woo,Ryu, Ji-Ho 한국군사과학기술학회 2014 한국군사과학기술학회지 Vol.17 No.1

In this paper, we proposed a Ku-band antenna that can be mounted on UAV. A proposed antenna structure has small size and light weight. It is considered long distance communication environment(LOS) and equipped UAV. Proposed antenna is designed $16{\times}2$ aperture coupled microstrip patch array antenna for high gain characteristics. In the measurement results, VSWR is less than 1.5 and the gain is over 21dBi in the bandwidth. Mechanical specifications of antenna assembly are ${\phi}250{\times}200mm$ of size and 3kg of weight.