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외음부에 발생한 Verrucous Carcinoma 1예
박제응,강정배,심정원,김홍배,이근영,강성원 대한부인종양 콜포스코피학회 1997 Journal of Gynecologic Oncology Vol.8 No.2
Verrucous Carcinoma(VC) of the female genital tract is a rare lesion, primarily affecting postmenopausal women. A case of VC of the vulva is reported. VC is a variant of squamous cell carcinoma that has distinctive clinical and pathologic characteristic, slowly growing locally invasive, non-metastasis pushing tumor with a rather benign histologic appearence, VC of the vulvar have often invaded deeply into adjacent tissues, demanding extensive surgery, and commonly associated with local recurrence. There still exist diagnostic difficulties and treatment is a matter of debate. It seems logical to treat the tumor by wide local excision. Radiation therapy should be contraindicated, and local application of podophyllin, bleomycin and cryosurgery are ineffective. Authors present a case of verrucous carcinoma of vulva, and literature is reviewed. The clinical and histologic features are described and therapeutic aspects are discussed on the basis of the literature.
김중석(JS Kim),정태범(TB Jung),박제응(JE Park),김종렬(JR Kim),강정배(JB Kang),김홍배(HB Kim),진현주(HJ Jin),오숙경(SK Oh) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.7
Objective: Chromosomal abnormalities of abortuses have also been used to investigate the most common etiology of spontaneous abortion, but the frequency and the types of spontaneous abortions have also demonstrated considerable variation among in different countries and races. Methods: So as to studies of the frequency and type of chromosomal abnormalities of abortuses , a cytogenetic study of 74 abortuses and their aborters was performed from January, 1994 to December, 1997 in Hallym University Kangnam Sacred Heart Hospital. Results: The frequency of abnormal karyotypes in abortuses was 40.0%[28/70 cases], of autosomal trisomy 42.7% [12/28 cases], of monosomy X 21.4%[6/28 cases], of polyploidy 10.7%[3/28 cases] and of structural anomalies 25.0%[7/28 cases]. The earlier gestational age when the loss occurs, got the higher the likelihood to be chromosomally abnormal. Among trisomies, chromosomes 21[33%], 18[25%] and 16[17%] were prevalent. There was no statistical significance of the frequency of chromosomal abnormality according to maternal age, but trisomy was slightly increased at older age. Structural abnormalities were present in 7 cases; 2 cases were Robertsonian translocation and 5 cases were inversion. The origin of structural abnormalities were classified as De novo in 5 patients, and familial tendency in two. One of the parents of two translocation cases was carriers with abnormal karyotype. Two parents of translocation cases were carriers with abnormal karyotypes. Conclusion: Our findings support that cytogenetic study is worth-while in couples presenting with a history of spontaneous abortion or older age.