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흉부 팬텀 CR 영상의 화질평가 및 피폭선량 경감에 관한 연구
김흥태,권수일,박일영,정환,Kim, Heung-Tae,Gwon, Su-Il,Park, Il-Yeong,Jeong, Hwan 대한디지털의료영상학회 1998 대한디지털의료영상학회논문지 Vol.4 No.1
With this experiment we have conclusion as follows. $\cdot$ Total FCR-9501 are 8 units. $\cdot$ All hospitals under study are conducting the high kvp radiographing with 115-120kvp and 4$\sim$10mAs. $\cdot$ The mean value of the chest exposure was 0.524$\sim$0.301mGy. $\cdot$ The percentage of the absorber finding from phantom was more the 85% with a range of 100$\sim$136 kvp. $\cdot$ The mean dose from phantom was 0.990mGy with 124 kvp and 16 mAs. $\cdot$ There is no difference in the amount of information due to the change of kvp and mAs, but some coarseness of images can be seen in the magnified images. $\cdot$ The resolving power was about 1.5/mm. $\cdot$ The increase and decrease of 10$\sim$30 kvp from common kvp has not influenced on the amount of information. $\cdot$ The exposure could be reduced by 0.170$\sim$0.570mGy.
열 충격 단백질(Heat shock protein, HSP70)의 기능 및 항암 치료제로서의 억제제(inhibitor) 개발동향
송진수, 박일영, 이수재 충북대학교 약품자원개발연구소 2013 약학논문집 Vol.28 No.-
The HSP70 proteins function as molecular chaperones that serve critical rolesin protein folding processes. These proteins also enhance cell survival following a variety of stressful situations, including heat, oxidative stress, and heavy metal toxicity, as well as by inflammation and other disease processes. The HSP70 family consists of ATPase, substrate-binding, and C-terminal domains. Substrate binding and relese is regulated by ATP hydrolysis and nucleotide exchange, which inturn are regulated by co-chaperones. The HSP70 genes are widely distributed across all prokaryotic and eukaryotic organisms, and the HSP70 family is highly conserved in evolution. Most of human tumors overexpress HSP70 family members, and expression of these proteins is significantly correlated with poor prognosis. In this review, the mechanism of action and function of the HSP70 family in cancer with the present trends of inhibitor development targeting HSP70 for cancer therapeutics in pharmacology will be discussed.
김양배,박일영 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.1
The crystal structure of diflunisal, 2', 4'-difluoro-4-hydroxy-3-biphenyl-carboxylic acid, was determined by single crystal X-ray diffraction technique. The compound was recrystallized from a mixture of acetone and water in monoclinic, space group C2/c, with a = 34.666(6), b = 3.743(1). c = 20.737(4) Å, β= 110.57(2)˚, and Z = 8. The calculated density is 1.324g/g/㎤. The structure was solved by the direct method and refined by full matrix least-squares procedure to the final R value of 0.045 for 1299 observed reflections. It was found that the molecules in the crystal are partially disordered. that is, the two equivalent conformers (180˚ rotated ones through C(1)-C(7)) are packed alternatively without regular symmetry or sequence. The two phenyl rings of the biphenyl group is tilted to each other by the dihedral angle of 43.3˚. The carboxyl group at the salicylic moiety is just coplanar to the phenyl ring, and the planarity of this salicylic moiety is stabilized by an intramolecular hydrogen bond of O(3)-H(O3)…O(2). The molecules are dimerized through the intermolecular hydrogen bonds at the carboxy1 group in the crystal.
히드록시프로필셀룰로오스와 카르보폴을 사이클로옥시게나제의 작용부위 모델
김양배,박일영,정우태 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.3
The active site of cyclooxygenase was modeled by complementary receptor-cavity mapping procedure using 3D structures of the non-steroidal antiinflammatory drugs (NSAIDs). A total of 50 NSAIDs were chosen as data ligands which compete the same site on the enzyme. Partial atomic charges were estimated, and the energetic differences for various conformations were calculated so as to meet the need for a most efficient overlapping of the probably-equivalent functional groups of the ligand molecules. The structure activity relationships of the NSAIDs, if available, were fully considered throughout the modeling. The overall shape of the model obtained is similar to a boot-without-bottom. Most of inner surface of the cavity appeared as hydrophobic: two polar counterparts except the carboxyl-binding position were found. By this model, some clear explanations could be given on the experimental observations which were not satisfiably understood yet.
Cho, Won-Jea,Kim, Eui-Ki,Park, Il Yeong,Jeong, Eun Young,Kim, Tae Sung,Le, Thanh Nguyen,Kim, Dae-Duk,Lee, Eung-Seok 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
A series of 58 3-arylisoquinoline antitumor agents were investigated for defining the phamacophroe model using comparative molecular field analysis (CoMFA) program. The studied compounds relatod to biosostere of benzophenanthridine alkaloid were synthesized and evaluated for antitumor cytotoxicity against human lung tumor cell (A 549). In order to perform the systematic molecular modeling study of these compounds, the conformational search was carried out based on the single X-ray crystallographic structure of 7,8-dimethoxy-3-phenylisoquinolin-(2H)-one(2). Interestingly, two types of structures having different dihedral angles between the isoquinoline ring and 3-aryl ring were found in the crystals. Therefore, CoMFA was performed two different, overlapping ways. The alignments of the structures were based on the common isoquinoline ring and 3-aryl ring. The 3-D-quantitative structure-activity relationship study resulted in significant cross-validated, conventional r^2 values equal to 0.715 and 0.927, respectively.
Isolation and Structures of Guaianolides from Carpesium macrocephalum
Kim, Mi-Ran,Kim, Chang-Soo,Hwang, Kyung-Hwa,Park, Il-Yeong,Hong, Seoung-Soo,Son, Jong-Keun,Moon, Dong-Cheul 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Two new guaianolides, 4α,10α-dihydrory-1β(H),5β(H)-guai-11(13)-en-8α,12-olide (2) and 4β,10β-dihydroxy-5α(H)-1,11(13)-guaidien-8α,12-olide (3), from Carpesium macrocephalum were isolated, and their structures were elucidated on the basis of spectroscopic studies.