간섭전류 자극 방법에 따른 말초혈류의 변화

박영한,황경옥,Park, Young-Han,Hwang, Kyoung-Ok 대한물리치료과학회 2011 대한물리치료과학회지 Vol.18 No.3

Purpose : The purpose of this study is to have examined the influence on the blood circulation by comparing the differences between stimulating the sympathetic ganglion and the muscle group among the stimulation variables in interferential current stimulation and to have found out the most effective stimulating mode for the improvement the peripheral blood circulation in the interferential current stimulation. Method : The subjects of the study is the men and women in the twenties, who are in great condition and have no pathological report for the blood circulation influence. The intensity of the inferential current stimulation is the medium degree, 100 bps constant current, which is the comfort and overt degree to confirm the muscle contraction. The areas stimulated by the interferential current stimulation are the stellate ganglion area in the seventh cervical vertebrae and the forearm muscle area. The stimulating time is twenty minutes long. After stimulating the two areas, the change of the blood circulation has been measured. Results : Both stimulating the sympathetic ganglion and stimulating the muscle, before and after interferential current stimulation, we have seen that the amount of blood circulation was increased significantly and statistically in both two groups(p<.01) and that the amount of blood circulation was increased significantly and statistically in the case of stimulating the sympathetic ganglion(p<.01). Conclusion : The conclusion we received that inferential current stimulation had the clear influence on increasing the peripheral blood circulation. And stimulating the sympathetic ganglion area is more effective than stimulating muscle area directly.

21세기 삶의 질과 한국지리학의 관제

박영한 대한지리학회 1999 대한지리학회 학술대회논문집 Vol.1999 No.-

서울 도심지역의 설정과 내부구조에 관한 연구

박영한 대한지리학회 1973 대한지리학회지 Vol.8 No.1

GO-25 : A case of clear cell vaginal cancer stage III

박영한,이혜란,임채춘,김성주,최수란,강정배 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

질 출혈을 주소로 응급실로 내원한 58세 여성에서 유리세포암 (clear cell carcinoma) 3기로 확진된 드문 증례가 발견되어 보고하는 바입니다. 환자는 13년 전 자궁근종으로 전자궁절제술을 받으셨던 분으로, 조직검사 후 질제거술(vaginectomy)과 골반 임파절제거술을 시행한 결과 골반 임파절 전이가 확인되었으며 Cisplatin 50 mg/m2를 투여하는 항암화학 방사선치료를 시행하고 있는 중이고, 현재 종양표지자(SCC)는 6.5에서 현저히 개선되어 정상화 되었다.

고산자 김정호의 생애 고찰

박영한 서울大學校 社會科學大學 地理學科 2003 地理學論叢 Vol.42 No.-

국소적으로 진행된 자궁경부암에서 동시 항암화학방사선치료의 효과

박영한,유희석,장기홍,전미선,윤종혁,유종만,이정필,이은주 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.4

목적 : 국소적으로 진행된 자궁경부암 환자들에 대한 치료로서 동시 항암화학방사선치료의 효과를 확인하고 그 부작용을 비교하고자 하였다. 연구 방법 : 1994년 9월부터 2000년 8월까지 아주대학교병원 산부인과를 방문하여 임상병기 Ⅱb에서 Ⅵa의 국소적으로 진행된 자궁경부암으로 진단 받은 환자들과, 병기 Ib나 Ⅱa로 진단된 환자 중 병소의 최대직경이 5 cm 이상인 거대 종괴 환자들 및 자기공명영상촬영상 직경 1 cm 크기 이상의 골반내 림프절 비대 소견을 보여 림프절 전이가 있는 것으로 추정되는 환자를 대상으로 하였다. 총 242명의 방사선치료를 받은 환자들 중 재발 고위험군을 대상으로 동시 항암화학방사선요법을 시행한 24명과 방사선치료만을 받은 62명의 치료 효과 와 부작용을 후향적으로 분석하였다. 골반 방사선조사는 45 Gy 시행 후 (중앙차폐 36-40 Gy에 시행) 골반의 국소 전이와 림프절 전이를 보인 경우 자궁 주위 조직에 총 5,800 cGy까지 추가 조사하였다. 통상적으로 하루에 1.8 Gy씩 주 당 5회 실시하였으며 고선량 근접치료로 A 점에 4 Gy 또는 5 Gy씩 6-7회 조사하였다. 항암화학치료는 방사선치료 제 1일과 29일에 cisplatin 75 ㎎/m2, 제 2일부터 5일과 제 30일부터 33일까지 5-FU 1000 ㎎/m2/day를 주사하였다. 부작용을 GOG 정의에 따라 평가하고 생존율과 재발율을 통계적으로 분석하였다. 결과 : 2년 생존율은 동시항암화학방사선치료를 받은 전체 18명의 대상 환자 중 3명이 사망하여 15명 (83.3%), 방사선치료군은 61명 중 15명이 사망하고 46명 (75.4%)이 생존함으로써 방사선치료에 비해 상대적 사망위험이 66% 감소하였다 (RR 0.34, p=0.092). 치료 종료 후 2년째에 동시항암화학방사선치료군 18명 중 2명 (11.1%)이 재발하고, 방사선치료군은 61명 중 19명 (32.3%)이 재발함으로써 방사선치료군의 재발위험에 비하여 동시항암화학방사선치료군은 32% (RR 0.68, p=0.5) 감소하는 효과를 보였다. 동시항암화학방사선치료 기간 중 나타난 부작용은 grade 3의 장염이 3명 (12.5%), grade 3의 백혈구 감소는 2명 (8.3%), grade 3의 빈혈은 1명 (4.1%), grade 4의 빈혈은 2명 (8.3%)에서 발생하였다. 단독 방사선치료시 급성 독작용은 grade 3의 장염이 7명 (11.3%), grade 3의 직장 출혈이 1명 (1%)으로써 동시항암화학방사선치료군에서 급성 부작용의 발생이 증가되는 경향을 보였다. 결론 : 국소적으로 진행된 자궁경부암 환자에서 동시항암화학방사선치료를 함으로써 재발율을 감소시키고, 무병생존율은 향상시킬 수 있었다. 그러나 동시항암화학방사선치료 환자군에서 급성 부작용이 증가하는 경향을 보였으나 적절한 처치가 가능하였다. Objective : The purpose of this study was to evaluate the efficacy and toxicity of concurrent chemoradiotherapy (CCRT) in loco-regionally advanced cervical cancer patients. Methods : The medical records of 24 patients were retrospectively reviewed who underwent CCRT' and 62 patients who had underwent radiation therapy alone at the Department of Obstetrics and Gynecology, Ajou University Hospital from September, 1994 to August 2000 for loco-regionally advanced cervical cancer (stage Ⅱb-Ⅳa and Ib-Ⅱa with bulky tumor mass or pelvic lymph node involvement detected by magnetic resonance imaging). Radiotherapy was performed for 7 weeks during which the patients underwent radiotherapy and chemotherapy concomitantly. Chemotherapeutic regimen consisted of cisplatin (75 ㎎/m2 on day 1, 4) and 5-FU (1000 ㎎/m2 on day 2-5, 30-33). The toxicity was assessed according to the GOG toxicity criteria. Results : In the CCRT group, 2 of 18 patients (11.1%) had recurrent disease. Of the 22 patients who were followed up, the overall survival rate was 83.3%, and the relapse-free survival rate was 89.9%. In the radiotherapy alone group, 19 of 61 patients (32.3%) had recurrent disease. Of the 62 patients who were followed up, the overall survival rate was 75.4% and the relapsed-free survival rate was 67.7%. Relative risk reduction rate of the death rate in the CCRT group was 66% (RR 0.34), and 32% (RR 0.68) in the recurrence rate. Acute toxicities in the CCRT group were enteritis grade 3:3 (12.5%), leukopenia grade 3:2 (8.3%), anemia grade 3:1 (4.1%) and grade 4:2 (8.3%). The acute toxicities in the radiation therapy alone group were enteritis grade 3:7 (11.3%), rectal bleeding grade 3:1 (1%). Increased acute toxicities developed in the CCRT group. Conclusion : This study shows improved overall survival rates and relapse-free survival rates but some increase in acute toxicity. It is suggested that CCRT be the standard treatment of loco-regionally advanced cervical cancer. Due to small size sample and short duration of follow up, further study of a large group of patients and the long term survival rate are necessary.

X-Ray Triple Crystal Diffraction Spectrometer의 제작과 그 응용

박영한,염효영,윤형근,민석기,박용주,Park Young-Han,Yeom Byo-Young,Yoon Hyng-Guen,Min Suk-ki,Park Young Joo 한국결정학회 1997 韓國結晶學會誌 Vol.8 No.1

고분해도의 X-선 산란을 위해 두 실험 방법이 개발됐다. 그 방법들은 (1) 2-결정 회절 스펙트로메터 (DCD)설치와 (2) 3-결정 회절 스펙트로메터 (TCD) 설치였다. Si(511)-시료(hkl)의 DCD배열로 Si(333), Si(004), GaAs(004)의 rocking curve를 그렸다. 또한 단일체 단색 평행기와 $K_{\alpha1}$ 선택기를 포함하는 Si(111)-Si(111)-Si(511)-sample(hkl)의 TCD배열로 Si(333), Si(004) 그리고 GaAs(004)의 rocking curve를 그렸다. DCD와 TCD에 의한 rocking curve의 FWHM의 차이가 논의됐다. DCD에 의한 $In_{0.037}Ga_{0.0963}As/GaAs$의 (004) 및 (115) 반사 토포그라프가 행해졌다. Two experimental methods have been developed for high resolution measurement of x-ray scattering. The methods used were (1) an x-ray double crystal diffraction (DCD) spectrometer set-up and (2) an x-ray triple crystal diffraction (TCD) spectrometer set-up. With the DCD arrangement of Si(511)-sample(hkl), rocking curves have been plotted for Si (333), Si(004) and GaAs(004). Also, with the TCD arrangement of Si(111)-Si(111)-Si(511)-sample(hkl) including monolithic monocro-collimator and $K_{\alpha1}$ selector, rocking curves have been plotted for Si(333), Si(004) and GaAs(004). The results of FWHM by DCD and TCD set-up have been compared each other and discussed. The reflection topographs (004) and (115) in an $In_{0.037}Ga_{0.0963}As/GaAs$ sample have been obtained by DCD set-up.

근육 근막 장애가 자세균형에 미치는 시각적 분석

박영한 대한물리치료학회 1997 대한물리치료학회지 Vol.9 No.1

1. The human body is the unification related to the powerful fascial network, I think. 2. Myofascial not only prevent and support the human body structure curdling but also keep the physical balance by dispersing traumatization properly. 3. Myofascial restriction will be developed into muscle deficiency and cause pains without releasing the muscle tension and the spasm. 4. Myofascial restriction affect and change the physical posture by losing the muscle elasticity and flexibility and by losing muscle supporting ability from gravitation 5. The partial myofascial restriction affect the muscle and the adjoining joint supporting gravitation and cause the unbalance of the entire body.

Follicular stimulating hormone enhances Notch 1 expression in SK-OV-3 ovarian cancer cells

박영한,김수진,정병훈,Thomas J Herzog,Jason Wright,Jan Kitajewski,임채춘,장봉림,강정배,김성주 대한부인종양학회 2010 Journal of Gynecologic Oncology Vol.21 No.2

Objective: Notch is known as a transmembranous receptor family with four homologous forms - Notch 1, Notch 2,Notch 3, and Notch 4 and related to cell fate regulation and angiogenesis. The purpose is to investigate the effect of follicular stimulating hormone (FSH) on the Notch 1 expression and proliferation in ovarian cancer cells. Methods: Human ovarian cancer cell line, SK-OV-3 and FSH were used. XTT cell proliferation and cell migration assay were carried out with FSH 100 mIU/mL and Notch 1 siRNA. Western blots and reverse transcriptase-polymerase chain reactions (RT-PCR) were carried out to determine the expression level of the Notch 1 protein and mRNA with FSH treatment in 0, 1, 5, 10, 100, 200, 300 mIU/mL concentrations. Immunofluorescent (IF) stains were performed in SK-OV-3 cell cultures with FSH 100 mIU/mL. Student-t tests were used in statistical analyses. Results: The SK-OV-3 have Notch 1 receptors in their natural status. FSH stimulated SK-OV-3 cells in XTT cell proliferation and cell migration assays and notch 1 siRNA inhibited. The expression level of Notch 1 protein and mRNA were increased in a dose dependent pattern according to FSH concentrations compared to untreated cells. IF stains also showed brighter Notch1 expressions in the FSH treated cells compared to the control cells. Conclusion: FSH enhances proliferation & migration and Notch 1 signaling in SK-OV-3 cells. The Notch signaling probably supports one of the cell proliferating mechanisms of FSH in ovarian cancer cells.

기조연설/21세기 삶의 질과 한국지리학의 과제

박영한 대한지리학회 1999 대한지리학회 학술대회논문집 Vol.1999 No.-