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박수연(Park Soo-Yun),김주연(Kim, Ju-Yeon) 한국실내디자인학회 2017 한국실내디자인학회 학술대회논문집 Vol.2017 No.5
The purpose of this study is to analyze the pedestrian"s walking road characteristics according to the store stype of the Chang-Dong Station. Recently, attention has been focused on urban landscapes in various areas. Accordingly, there is a lot of effort and diverse activities to create clean, safe and beautiful streets. In particular, pedestrians around the area are affected by street walking along the street. The representative element of the aspect of the landscape is the type and color of the Stores in the building. Therefore, depending on the type of store, the distance that the building faces depends on the atmosphere. Therefore, depending on the type of stores, the buildings will have image characteristics. The distance across these buildings affects pedestrians choice of walking distances. The aim of this study is to analyze the walking road type that has been influenced by chang-dong commercial distribution zones to finally present the ultimate in walking characteristics. Also, this research is meaningful in establishing the direction of improvement of the existing chang-dong station and the framework for future commercial space planning.
박수연(Park, Soo-Yun),김주연(Kim, Ju-Yeon) 한국실내디자인학회 2018 한국실내디자인학회 학술대회논문집 Vol.20 No.1
The physical interior space, which contains our daily lives, creates an atmosphere in which a number of sensation-induced elements gather to create an atmosphere, thereby allowing people to choose or create an atmosphere that they prefer. Color also directly affects the human perception, affecting the overall mood perception of space. This is because human visual abilities are greatly affected by color. Meanwhile, space is physically color coded, recently visitors and users of space want to express their colors through applications while taking pictures of space. Therefore, even the same physical space can be expressed in new emotional colors through various filters in the application. Therefore, this study depends on what color and overall tone colors one chooses in a physically color-colored space chooses the preferred atmosphere, and the result is how people choose the preferences. Therefore, this study has created a variety of selective space design environments for which users of space themselves can adjust the tone of the space through lighting color or other process in addition to physical color. In addition, if these studies are conducted, they will generally show the preference center criteria of the mood people choose, and therefore reduce the important design elements and preferences that experts will present.
정상 및 저산소 배양에서 사람 태반융모이식편의 조직 생존에 대한 연구
박세나 ( Se Na Park ),이유선 ( Yu Sun Lee ),심인숙 ( In Suk Shim ),이수윤 ( Soo Yoon Lee ),박미혜 ( Mi Hye Park ),김승철 ( Seung Cheol Kim ),박수연 ( Soo Yun Park ),전선희 ( Sun Hee Chun ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.3
연구목적: 최근 자궁-태반 간 순환 감소로 인해 유발되는 만성적인 저산소증으로 인한 태반의 손상이 전자간증 또는 자궁 내 태아 성장 지연의 주요 원인 중 하나로 알려지면서 저산소 상태에서의 태반의 특성에 대한 연구가 진행되어 왔다. 본 연구에서는 사람 태반융모이식편을 정상산소 상태와 저산소 상태에서 배양하고, 조직의 생존 여부와 그 정도를 평가하여 봄으로써 태반 저산소증에 대한 시험관내 (in vitro) 실험 연구에 있어서 사람 태반융모이식편을 이용한 배양 실험 기법의 유효성을 확인하고자 하였다. 연구방법: 본원 산부인과에서 제왕절개술로 분만한 임신 37주 이상 정상 임산부의 태반 조직 9예를 대상으로 태반융모이식편을 정상산소 상태와 저산소 상태에서 72시간 동안 배양 후 광학현미경 관찰, 배양 후 시간 간격 (0, 6, 12, 24, 48, 72시간)에 따른 젖산 탈수소효소 (lactate dehydrogenase, LDH) 측정에 의한 생화학적 관찰을 시행하였다. 세포고사 (apoptosis)를 나타내는 TdT-mediated dUTP nick end labelling (TUNEL) 분석을 실시하여 조직 생존 여부와 그 정도를 평가하였다. 연구결과: H&E 염색된 절편을 광학현미경을 이용하여 관찰한 결과, 시간에 따른 배양 후 세포 통합성의 소실은 관찰되지 않았다. 젖산 탈수소효소 분석에 의해 측정 비교된 9개의 태반 이식편의 정상산소 상태와 저산소 상태에서의 배양 후 시간 별 평균 조직 생존률은 52.3∼67.6%로 나타났으며, 두 군 사이에 통계학적으로 의미있는 차이는 보이지 않았다. 정상산소 상태와 저산소 상태의 태반융모이식편의 조직 생존률은 두 군 모두 배양 후 24시간까지는 61.2∼67.6%를 유지하다가 시간이 경과함에 따라 점차 감소되는 양상을 보였다. 세포고사 여부를 알아보기 위해 시행한 TUNEL 결과, 정상산소 상태와 저산소 상태의 두 군의 배양 후 시간별 모든 샘플에서 음성 소견이 관찰되었다. 결론: 시험관내 실험 연구에 있어서 사람 태반융모이식편을 이용한 배양실험 기법은 전자간증, 자궁 내 태아 성장 지연, 조기 진통 등 태반의 저산소증과 관련된 산과적 질환의 발생 기전을 규명하는 데 유용한 연구 기법임을 알 수 있었다. 앞으로 본 연구의 조직 생존률을 극대화하기 위한 다양한 시도들이 필요할 것으로 본다. Objective: In vitro study systems for research of placental hypoxia are needed, among which human placental villous explant culture technique under experimentally variable condition is commonly used. So we performed this study to assess the viability of placental villous explant in normoxic and hypoxic culture that can provide validity for that system. Method: Placental villous explant tissues obtained from 9 cases of normal term pregnancies were incubated in normoxic (20% O2) and hypoxic (2~5% O2) condition for 72 hours. The viability of tissue was evaluated morphologically by microscopic examination and biochemically by LDH assay at variable time interval (0, 6, 12, 24, 48, 72 hours). The apoptosis of the tissue was assessed by TUNEL assay. Result: By light microscope, all of H&E stained placental explant tissue sections in normoxic and hypoxic culture showed intact villous integrities without definitive syncytial sloughing and fibrinoid necrosis as time elapsed. Tissue viability of LDH assay during 6, 24, 48, 72 hours of placental villous explants showed over all 52.3~67.6% and didn`t show statistically significant difference between normoxic and hypoxic culture. Tissue viability in both groups maintained 61.2∼67.6% for the first 24 hours and eventually decreased with time. TUNEL assay showed over all negative findings in normoxic and hypoxic culture at different time periods. Conclusion: In vitro human placental explant culture system can be a useful and feasible technique for research of placental hypoxia which is related to development of obstetrical complications such as preeclampsia, intrauterine fetal growth restriction and preterm labor and so on. But our in vitro placental explant system needs some modification in culture condition and technique for maximizing viability of the tissue.
류마티스 관절염의 임상 연구 동향: 2008년 이후 국내 학술 문헌을 중심으로
한윤희 ( Yun-hee Han ),우현준 ( Hyeon-jun Woo ),박수연 ( Soo-yeon Park ),이창훈 ( Chang-hoon Lee ),정종혁 ( Chong-Hyuk Chung ),이명수 ( Myeung-Su Lee ),이정한 ( Jung-han Lee ) 한방재활의학과학회 2021 한방재활의학과학회지 Vol.31 No.3
Objectives To investigate the trends in clinical study on rheumatoid arthritis in all academic fields in Korea. Methods We searched seven Korean web databases for clinical studies published from 2008 to 2021. All identified studies were reviewed and classified by the year of publication, academic field, and study design. Results A total of 347 clinical studies were selected. An average of 26.7 studies were published each year. Regarding the distribution of studies by academic fields, 309 studies were published in the medical field and 17 studies were published during the same period in Korean medicine, and 21 studies were published in other fields. The distribution of studies by study design was as follows: 8 studies, meta-analyses; 5 studies, systematic reviews; 16 studies, experimental studies; and 318 studies, observational studies. Conclusions Multidisciplinary access and management are required for the early diagnosis of rheumatoid arthritis, effective management of disease progression, and prevention of rheumatoid joint deformities. Additionally, study design with high-level of evidence on the intervention of rheumatoid arthritis are warranted. (J Korean Med Rehabil 2021;31(3):19-29)
장준영,박수연,김종식,최병기,송기원,Jang, Joon-Yung,Park, Soo-Yun,Kim, Jong-Sik,Choi, Byeong-Gi,Song, Gi-Won 대한방사선치료학회 2011 대한방사선치료학회지 Vol.23 No.2
Purpose: Opposing portal irradiation with helmet field shape that has been given to a patient with brain metastasis can cause excess dose in patient's scalp, resulting in hair loss. For this reason, this study is to quantitatively analyze scalp dose for effective prevention of hair loss by comparing opposing portal irradiation with scalp-shielding shape and tomotherapy designed to protect patient's scalp with conventional radiation therapy. Materials and Methods: Scalp dose was measured by using three therapies (HELMET, MLC, TOMO) after five thermo-luminescence dosimeters were positioned along center line of frontal lobe by using RANDO Phantom. Scalp dose and change in dose distribution were compared and analyzed with DVH after radiation therapy plan was made by using Radiation Treatment Planning System (Pinnacle3, Philips Medical System, USA) and 6 MV X-ray (Clinac 6EX, VARIAN, USA). Results: When surface dose of scalp by using thermo-luminescence dosimeters was measured, it was revealed that scalp dose decreased by average 87.44% at each point in MLC technique and that scalp dose decreased by average 88.03% at each point in TOMO compared with HELMET field therapy. In addition, when percentage of volume (V95%, V100%, V105% of prescribed dose) was calculated by using Dose Volume Histogram (DVH) in order to evaluate the existence or nonexistence of hotspot in scalp as to three therapies (HELMET, MLC, TOMO), it was revealed that MLC technique and TOMO plan had good dose coverage and did not have hot spot. Conclusion: Reducing hair loss of a patient who receives whole brain radiotherapy treatment can make a contribution to improve life quality of the patient. It is expected that making good use of opposing portal irradiation with scalp-shielding shape and tomotherapy to protect scalp of a patient based on this study will reduce hair loss of a patient.
CGH를 이용한 한국인 자궁경부 편평상피세포암 세포주의 염색체 DNA 변이 분석
오관영 ( Kwan Young Oh ),박수연 ( Soo Yun Park ),정지학 ( Ji Hak Jeong ),황인택 ( In Taek Hwang ),박준숙 ( Joon Sook Park ),박미혜 ( Mi Hye Park ),전선희 ( Shun Hee Chun ),김승철 ( Seung Chul Kim ),김종일 ( Jong Il Kim ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.3
목적: 비교 유전자 부합법 (comparative genomic hybridization, CGH)은 일종의 새로운 FISH 방법으로 기존의 세포유전학적 분석으로는 용이하지 않았던 모든 염색체 상의 상대적인 염색체 변이를 한번에 알 수 있게 해준다. 이에 본 연구를 한국인의 자궁경부 편평상피 세포암 세포주를 이용해 염색체 DNA 변이를 분석해 보고자 하였다. 연구 방법: 본 연구에서는 한국인 자궁경부 편평상피세포암 세포주 SNU-17, SNU-682와 Objective: Comparative genomic hybridization (CGH) is a new fluorescence in situ hybridization (FISH) technique to identify genomic aberrations in cancers. The purpose of this study was to analyze non-random chromosomal DNA aberrations involved in cervica