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두경부암종에서의 Cyclooxygenase-2와 5-Lipoxygenase 병합 억제의 향상된 항암 효과
박석우,성명훈 대한이비인후과학회 2010 대한이비인후과학회지 두경부외과학 Vol.53 No.7
Background and Objectives It has recently been found that arachidonate 5-lipoxygenase (5-lipoxygenase, 5-LO or ALOX5), another molecule capable of arachidonic acid (AA) metabolism,might promote cancer cell viability through unique mechanisms. Interestingly, 5-LO appears to have similar mechanisms to prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2,COX-2) in the regulation of cell viability, although it often utilizes different signaling pathways. We found that not only COX-2 expression but also the expression of 5-LO is up-regulated in some of head and neck squamous cell carcinoma (HNSCC) cell lines. From these findings, we hypothesized that the combined inhibition of these pathways would be likely to be a more effective anti-cancer modality with less side-effect in HNSCC. Materials and Method In HNSCC cell lines, we investigated the expression of COX-2 and 5-LO by western blotting and checked the levels of prostaglandin E2, leukotrien B4 and vascular endothelial growth factor (VEGF) by enzyme-linked immunosorbent assay. We performed MTT assay to analyze the growth-inhibitory effect of COX-2 and 5-LO inhibition. Results Actually, combined knock-down of COX-2 and 5-LO resulted in an enhanced inhibitory effect in cell proliferation of HNSCC than a single inhibition of COX-2. Furthermore, we observed that VEGF production was blocked more effectively by combined treatment of COX-2and 5-LO small interfering RNA (siRNA) in all tested cell lines. Conclusion Therefore, the combined inhibition of COX-2 and 5-LO may be one way to overcome low efficacy of single inhibition of COX-2 in cancer cells with both COX-2 and 5-LO overexpression. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:430-5
수중트레드밀훈련이 만성뇌졸중 환자의 보행능력에 미치는 영향
박석우,송창호 대구대학교 특수교육재활과학연구소 2011 특수교육재활과학연구 Vol.50 No.2
본 연구는 수중트레드밀훈련이 만성 뇌졸중 환자의 보행능력에 미치는 영향을 확인하고자 시행하였다. 연구의 대상은 I재활병원에 입원하고 있는 편마비 뇌졸중 환자 20명이었으며, 수중트레드밀군 10명과 대조군 10명으로 구분하였다. 수중트레드밀군과 대조군 모두 동일하게 1회 30분씩 주 5회, 총 4주 동안 일반적인 재활프로그램을 시행하였으며, 수중트레드밀군에게 추가로 훈련을 1회 30분씩 주 2회, 총 4주 동안 실시하였다. 훈련 전과 후에 보행 시공간 보행변수를 검사하였으며 다음과 같은 결과를 얻었다. 보행능력은 시간적인 변수와 공간적인 변수 모두에서 수중트레드밀군에서는 유의한 증가를 보였으며(p<.05) 대조군에서는 유의한 증가를 보이지 않았다. 본 연구를 통해 수중트레드밀훈련이 만성 뇌졸중으로 인한 편마비 환자의 보행능력을 증진시키는데 있어 효과적인 운동방법임을 확인하였다. 앞으로 뇌졸중 및 다양한 질환의 환자의 운동 프로그램의 연구를 통해 수중운동을 적극적으로 활용할 수 있을 것으로 생각한다. This study aimed at investigating the effect of the gait training using underwater treadmills on gait ability of chronic stroke patients. A total of 20 hemiplegic stroke patients hospitalized in I rehabilitation hospital in Incheon were screened and randomized for the group selections, under-water treadmill and control groups. 10 under-water treadmill group patients were treated with the under-water treadmill while the rest left untreated. All the patients from both groups received their usual rehabilitation therapy two times a week, 30 minutes per session for four weeks, and only the under-water treadmill group was subjected to additional 30 minutes of under-water treadmill training two times a week. Changes of gait ability before and after planned treatment were examined, and the results are as follows. Significant improvement in gait ability was observed in all subjects that spatial and temporal factors irrespective of the under-water treadmill treatment(p<.05) and did not observed in all subjects irrespective of the control groups(p<.05). It was confirmed in this study that the gait training using under-water treadmill was effective therapy in improving walk capability of chronic stroke patients as proven by resulting improvements in gait speed and cadence, affected area step and stride length after the treatment. Therefore, it is expected that the use of the under-water treadmill training method would actively be employed in the field through further studies on training programs designed not only for chronic stroke patients, but also for others suffering from various diseases.
박석우,이진영,이윤진,권은정,윤기애,Jeong Jong Cheol,진호준,나기영,김세중 대한신장학회 2023 Kidney Research and Clinical Practice Vol.42 No.5
Background: Prevention and diagnosis of postcontrast acute kidney injury (AKI) after contrast-enhanced computed tomography is burdensome in outpatient department. We investigated whether an electronic alert system could improve prevention and diagnosis of postcontrast AKI. Methods: In March 2018, we launched an electronic alert system that automatically identifies patients with a baseline estimated glomerular filtration rate of <45 mL/min/1.73 m2, provides a prescription of fluid regimen, and recommends a follow-up for serum creatinine measurement. Participants prescribed contrast-enhanced computed tomography at outpatient department before and after the launch of the system were categorized as historical and alert group, respectively. Propensity for the surveillance of postcontrast AKI was compared using logistic regression. Risks of AKI, admission, mortality, and renal replacement therapy were analyzed. Results: The historical and alert groups included 289 and 309 participants, respectively. The alert group was more likely to be men and take diuretics. The most frequent volume of prophylactic fluid in historical and alert group was 1,000 and 750 mL, respectively. Follow-up for AKI was more common in the alert group (adjusted odds ratio, 6.00; p < 0.001). Among them, incidence of postcontrast AKI was not statistically different. The two groups did not differ in risks of admission, mortality, or renal replacement therapy. Conclusion: The electronic alert system could assist in the detection of high-risk patients, prevention with reduced fluid volume, and proper diagnosis of postcontrast AKI, while limiting the prescribing clinicians’ burden. Whether the system can improve long-term outcomes remains unclear.
박석우,박용석,장호남 ( Seok Woo Park,Yong Seok Park,Ho Nam Chang ) 한국화학공학회 1990 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.28 No.1
Permeation characteristics of NaCl solution were studied using a cellulose acetate reverse osmosis spiral-wound module. The pure water permeability through the module was 0.272 L/㎡h atm which amounted to 13 % of the cell test. The lower permeability of the module is attributed to the permeate flow resistance through the support inserted between the two membrane envelopes. As the pressure was increased, the permeability and salt rejection increased. The permeability and the flux were dependent on the inlet flow rate to the module and the way of packing. For a uniform flow distribution in the module, several distributor tips were designed, among which 30˚cone-type distributor was found to be most suitable.