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- 저자 : 박석돈 ( Park Seog Don ) (검색결과 3 건)
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포도구균성 열상 피부 증후군 25예의 임상적 분석에 의한 재분류
강정대 ( Kang Jeong Dae ),박석돈 ( Park Seog Don ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.4
N/A Background: Dermatofibromas are common benign tumors which occur in the skin. They have been divided into fibrous lesions, composed entirely of almost entirely of fibroblasts and collagen, and cellular lesions composed to a significant degree of phagocytic cells with the appearance of histiocytes. A cellular variant characterized by increased cellularity, storiform arrangement, larger size, and location in the deep dermis, often with extension into the superficial subcutaneous tissue may be difficult to differentiate from dermatofibrosrcoma protuberans. There is an incessant controversy over the histogenesis of dermatofibromas, although many authors consider that these tumors derive from primitive mesenchymal cells. The recent development in immunohistochemical staining technology and ultrastructural study revealed various cellular proliferation in the lesion, including fibroblast, histiocyte and myofibroblast. Objective: Our purpose was to study by immunohistochemistry the defferences between fibrous and cellular dermatofibromas and to find the relationship between the myofibroblast and the histogenesis of dermatofibroma. Methods: We will select 36 cases of dermatofibromas which include 27 fibrous and 9 cellular types. We have studied the immunophenotype of 36 dermatofibromas using antibodies against vimentin, smooth muscle actin, desmin, CD34, factor XⅢa, CD68 and MMP 11. Results: All dermatofibromas were positive for vimentin, smooth muscle actin, and factor XⅢa, but negative for desmin and CD34. All cellular type were positive for CD68, but 24/27 of the fibrous type were positive for CD68. MMP 11 was positive in 6/9 of the cellular type and 25/27 of the fibrous type. The degree of staining for vimentin, factor XⅢa, CD68, and MMP 11 was not different in both types. But the degree of staining for smooth muscle actin in the fibrous type was higher than in the cellular type. Conclusion: The differences in the degree of staining for smooth muscle actin and the positivity for CD68 suggest the possibility of a different differentiation of dermatofibroma between cellular and fibrous types. The prominent vimentin and smooth muscle actin immunoreactivity and desmin non-reactivity may suggest that the myofibroblast may play a role, in part, for developing dermatofibromas. Further investigations with ultrastructural study using electron microscopy and double/triple immunohistochemical staining would be necessary. (Korean J Dermatol 2004;42(3):256~263)
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강정대 ( Kang Jeong Dae ),김소진 ( Kim So Jin ),윤녕훈 ( Yun Nyeong Hun ),박석돈 ( Park Seog Don ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.11
Cutaneous extramedullary plasmacytomas are rare in patients with multiple myeloma, they usually indicate a large tumor cell burden and fatal outcome. A 55-year-old man presented with multiple cutaneous tender nodules or masses on whole body. A biopsy specimen of cutaneous nodule showed dermal infiltration by well differentiated plasma cells. Many atypical and immature plasma cells were found in a bone marrow smear and biopsy. A serum protein electrophoresis revealed elevated quantities of Ig G-globulin with type 入 light chain. The patient was treated with VAD(vincristine, adriamycin, dexamethasone) chemotherapy, but died with pulmonary edema and acute respiratory distress syndrome. We report a fatal case of multiple myeloma first presenting as multiple extramedullary cutaneous plasmacytomas. (Korean J Dermatol 2003;41(11) : 1517∼1520)
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백서 성체 창상에서 antisense TGF-β₁oligodepxynucleotides가 TGF-β₁의 유전자 발현과 교원질 합성에 미치는 영향
박석돈,유병표,김형민,정헌택,최병민,최현준,유석근 大韓成形外科學會 1996 Archives of Plastic Surgery Vol.23 No.2
Adult wounds heal with scar formation, whereas fetal wounds heal without scarring and with a lesser inflammatory and cytokine response. Resently transforming growth factor (TGF) -βis known to play an important role in scar formation following tissue injury. Therefore we suggest that antisense TGF-β₁oligodeoxynucleotides (ODNs) complementary to TGF-β₁mRNA might decrease expression of TGF-β₁gene in dermal wound of the mouse. To evaluate this concept, we tested the effects of antisense ODNs targeted to TFG-β₁mRNA by topical application of the chemical on the skin wound. Phosphorothioate antisense ODNs were employed to retard their degradation. Northern blot analysis of on set of animals showed that the wounded skin treated with antisense ODNs exhibited no detectable levels of TFG-β₁mRNA, whereas the wounded skin treated with sense TGF-β₁ODNs expressed significant amounts of TGF-β₁ODNs treated wound tissue contained much less collagen than did the control wounds. In conclusion, our results indicate that antsense TGF-β₁ODNs could be used for ameliorating scar formation during wound healing.
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