외단열 고정 방법에 따른 적정 접착강도 제안에 관한 연구

박완구 ( Wan Goo Park ),안기원 ( Ki Won An ),박진상 ( Jin Samg Park ),박구병 ( Ku Byoung Park ),오상근 ( Sang Keun Oh ) 한국건축시공학회 2012 한국건축시공학회 학술발표대회 논문집 Vol.12 No.1

Recently outside insulation is applied on the building. Adhesion mortar and anchor are used fixing method of outside insulation. However, a research on proper Adhesion Strength is not performed. So outside insulation exfoliate from building in rainy with winds. Therefore, this research suggest proper adhesion strength about conjugation method of outside insulation. As a result, adhesion way using the adhesive mortar + anchor is best. And proper adhesion strength is over 1,065 N.

능동전력필터의 현장적용사례 보고

박기원(Ki-Won Park),권병기(Byeong-Ki Kwon),박창주(Chang-Joo Park),조응상(Eung-Sang Cho) 대한전기학회 2002 대한전기학회 학술대회 논문집 Vol.2002 No.7

유연한 로봇팔의 선단위치 제어를 위한 이산시간 H<SUB>∞</SUB> 제어기 설계에 관한 연구

박기원(Ki-Won Park),최연욱(Yeon-Wook Choe),이형기(Hung-Ki Lee) 제어로봇시스템학회 2003 제어로봇시스템학회 합동학술대회 논문집 Vol.2003 No.12

동적형 관내제빙 빙축열 시스템에 대한 기초적 연구

박기원(Ki-Won Park),오종택(Jong-Tack Oh),오후규(Hoo-Kyu Oh),이나바히데오(Hideo Inaba) 대한설비공학회 2000 대한설비공학회 학술발표대회논문집 Vol.2000 No.-

청심보혈탕(淸心補血湯)의 항암(抗癌) 및 면역증강효과(免疫增强效果)에 관(關)한 실험적(實驗的) 연구(硏究)

박세기,류봉하,박동원,류기원,Park, Se-Ki,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Ki-Won 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.1

The aim of this experimental study was to evaluate the anti-tumor effects of Chungsimbohyeltang through investigation about viability of tumor cell by MTT assay, survival period of mice transplanted with L-1210 cells, growth inhibition on the tumor cell, body weight variation in mice transplanted with sarcoma-180 cells and its immunomodulatory effects through the investigation on delayed type hyper-sensitivity, the hemagglutinin and hemolysin titers for humoral immune response, the appearance of rosette forming cells for cell-mediated immune response, the natural killer cell activity, the transformation of lymphocyte, the productivity of Interleukin-2 and phagocytic index K was performed in immune-depressed ICR mice induced by methotrexate treatments. The results were as follows ; 1. $IC_{50}$ of Chungsimbohyeltang treated group was 5.85mg/ml in SNU-C4 cell, 1.38mg/ml in SNU-396 cell, 0.21mg/ml in SNU-1 cell, so it had low anti-tumor activity. 2. The both groups of Chungsimbohyeltang extract 10mg/kg and Chungsimbohyeltang extract 20mg/kg had no toxicity and the group of Chungsimbohyeltang 20mg/kg which was shown 120% in ILS had the effect of life prolongation in mice transplanted with L-1210 cells. 3. In the growth inhibition on the tumor cells, only the group of Chungsimbohyeltang extract 20mg/kg was noted and in the weight variation in mice transplanted with sarcoma-180 cells, both groups of Chungsimbohyeltang extract had a significant effect. 4. In the delayed type hypersensitivity and appearance of rosette forming cells, both groups of Chungsimbohyeltang extract didn't have any significant effect. 5. The hemagglutinin titers was slightly increased with no significance, and the hemolysin titers was significantly increased in the only group of Chungsimbohyeltang extract 20mg/kg. 6. The natural killer cell activity of the Chungsimbohyeltang extract groups was significantly increased in the ratio of 100:1 of effector and target cells, but it was not significantly increased in the ratio of 50:1, 10:1. 7. The transformation of lymphocyte and the productivity of Interleukin-2 were increased significantly and in dose-dependent manner in both group of Chungsimbohyeltang extract. 8. The phagocytic effect of macropage was significantly increased in both groups of Chungsimbohyeltang extract. Considering the results above, we could conclude that Chungsimbohyeltang have an indirect anti-tumor effect through the modulation of immunme response, although it had not toxicity on the tumor cell it self.

원자력 발전소 공기 조화용 HEPA 필터 설계

박종범(Jong Beom Park),권태종(Tae Jong Kwon),문기원(Ki Won Moon),이세엽(Se Yup Lee) 대한전기학회 2000 대한전기학회 학술대회 논문집 Vol.2000 No.7

부모의 방임 및 학대가 청소년의 학교생활적응에 미치는 영향

박기원(Ki Won Park) 한국아동학회 2014 아동학회지 Vol.35 No.1

In this paper, the effects of parental neglect and abuse on school adjustment mediated by social withdrawal in adolescents were examined using a sample of 2,163 second grade middle school students(1,096 boys and 1,067 girls) from the Korean Child and Youth Panel Survey(KCYPS) data set. All research variables were measured using self-reported questionnaires. They were analyzed by means of Structural Equation Modeling. The results indicated that parents` abuse had no direct effect, but there was an indirect effect on adolescents` school adjustment mediated by adolescents` social withdrawal. Parental neglect had a direct effect on adolescents` school adjustment and also had an indirect effect on adolescents` school adjustment mediated by social withdrawal. The results indicate that parental neglect is a more significant contributor than adolescents` social withdrawal on adolescents` school adjustment. The results of this study show that parenting attitude, more specifically parental neglect, tend to be more important factors on school adjustment compared to adolescents` psychological problems, such as social withdrawal in adolescence. Taken together, these findings suggest that interventions aimed at improving parental neglect and adolescents` social withdrawal need to be emphasized if adolescents are to better adjust to school life.

하기도 감염 환아에서 분리된 Adenovirus 1, 2, 5 혈청형의 유전체형 분석

박기원,최은화,정지태,이환종,박기호,Park, Ki-Won,Choi, Eun-Hwa,Choun, Ji-Tae,Lee, Hoan-Jong,Park, Ki-Ho 대한소아감염학회 2005 Pediatric Infection and Vaccine Vol.12 No.2

Purpose : The purpose of this study was to examine the molecular epidemiology and genetic variability of adenovirus(Ad) serotypes Ad1, Ad2, and Ad5 over 14 years in Korea. Methods : A total of 382 adenoviral strains isolated from the nasopharyngeal aspirates of children with lower respiratory tract infections in Seoul, Korea from November 1990 to February 2003 were serotyped by neutralization assay with type-specific antisera. Viral DNAs were extracted from infected cell lysates by the modified Hirt procedure. Genome type(GT) was determined by DNA restriction analysis with 12 restriction enzymess(BamHI, BclI, BglI, BglII, BstEII, EcoRI, HindIII, HpaI, SalI, SmaI, XbaI, and XhoI). To evaluate the genetic relatedness, pairwise comigrating restriction fragments(PCRF) analysis was performed. Results : Of 382 strains, 33 strains(9%) were Ad1, 45 strains(12%) were Ad2, and 24 strains(6%) were Ad5. Eighteen GTs(Ad1p1-Ad1p7, Ad1a, Ad1b, Ad1b1-Ad1b3, Ad1c, Ad1d, Ad1e, Ad1e1, Ad1e2, Ad1f) among Ad1, 24(Ad2p1-Ad2p11, Ad2a, Ad2a1-Ad2a6, Ad2b, Ad2c, Ad2d, Ad2e, Ad2e1-Ad2e3) among Ad2, and 10(Ad5p1, Ad5p2, Ad5a, Ad5a1-Ad5a7) among Ad5 strains were identified. One or two strains of the vast majority of GTs were isolated during the study period while a few GTs were identified sporadically with more than 2 strains. It is notable that some GTs such as Ad1p5 and Ad5a1 appeared in cluster during a short period. In analysis of genetic relatedness, the degree of PCRFs(pairwise comigrating restriction fragments) for Ad1 varied from 79 to 99%, for Ad2, 82 to 99%, and for Ad5, 85 to 99%. Conclusion : This study established the comprehensive nomenclature systems of Ad1, Ad2, and Ad5. Diverse GTs identified in this study have crucial implications in the genomic diversity and epidemiological characteristics of Ad1, Ad2, and Ad5. 목 적 : DNA 제한 효소 분석법을 이용한 아데노바이러스의 유전체형 분석 방법은 많은 연구자들이 서로 다른 종류의 제한 효소와 명명법을 사용하여 분류함으로써, 아직까지 체계적인 분류 체계가 정립되어 있지 않다. 본 연구는 Li와 Wadell이 제안한 제한 효소 분석법과 명명법을 이용하여 국내에서 최근 14년 동안 분리된 아데노바이러스 혈청형 1, 2, 5형에 대한 유전체형을 분류하고, 그 분자 역학과 유전체형 상호 간의 연관성을 밝히고자 시행하였다. 방 법 : 1990년 11월부터 2003년 2월까지 하기도 감염으로 서울대학교병원 소아과에 입원하였거나, 인접 지역의 종합병원 소아과에 입원한 소아들로부터 채취한 비인두 흡인물을 검체로 하여 HEp-2 세포주에서 배양 후 간접면역형광검사로 확인하고, 분리된 아데노바이러스를 항혈청 1, 2, 3, 4, 5, 6, 7, 11에 대한 세포독성 효과를 관찰함으로 혈청형을 결정하였다. 혈철형 1, 2, 5형을 대상으로 DNA를 추출하고 12가지 제한 효소 BamHI, BcI, BglI, BglII, BstEII, EcoRI, HindIII, HpaI, SalI, SmaI, XbaI, XhoI로 절단한 후 전기영동 시키고 나타나는 분절 형태를 각 혈청형의 표준주와 비교하여 분석하였다. 유전체형간의 상관성을 비교하기 위하여 PCRF 분석을 시행하였다. 결 과 : 아데노바이러스 분리주 382주를 대상으로 혈청형을 확인한 결과, 1형 33(9%), 2형 45(12%), 3형 107(28%), 4형 16(4%), 5형 24(6%), 6형 8(2%), 7형 116(30%), 11형 9(2%), 그 외의 형들이 24(6%)주로 각각 나타났다. 변이 유전체형은 혈청형 1형 18종류, 2형 25종류, 5형 10종류가 분류되었으며 Ad1p1-Ad1p7, Ad1a, Ad1b, Ad1b1-Ad1b3, Ad1c, Ad1d, Ad1e, Ad1e1, Ad1e2, Ad1f; Ad2p1-Ad2p11, Ad2a, Ad2a1-Ad2a6, Ad2b, Ad2c, Ad2d, Ad2e, Ad2e1-Ad2e3; Ad5p1, Ad5p2, Ad5a, Ad5a1-Ad5a7로 명명되었다. 본 연구에서는 표준주나 이전에 보고 된 유전체형과 일치하는 유전체형은 분리되지 않았다. 대부분의 유전체형은 전 연구기간 동안 1~2주만 분리되었고 일부 유전체형들은 산발적으로 2회 이상 반복 분리되었다. 유전체형 Ad1p5나 Ad5a1와 같이 유행성으로 분포하는 유전체형도 관찰되었다. 혈청형 1형 유전체형 간의 PCRF는 79~99%로 Genomic cluster 1과 2로 구분되었고, 2형과 5형은 각각 82~99%와 84~99%로 모두 80% 이상이었다. 결 론 : 본 연구를 통하여 국내에서 분리된 아데노바이러스 혈청형 1, 2, 5형의 다양한 유전체형을 체계적으로 분석할 수 있었다. 혈청형 1, 2, 5형이 주로 산발성 감염을 일으키는 것으로 알려져 왔으나, 유전체형에 따라 역학적 특징이 다르게 나타날 수 있으며, 이는 DNA의 변형에 의한 유전체형의 변화가 바이러스의 감염력과 생존력에 변화를 일으켰을 가능성을 시사한다. 본 연구 결과는 혈청형 1, 2, 5형의 비교 자료로 활용될 수 있을 뿐만 아니라, 변이 유전체형들에 대한 정보를 제공함으로써 백신 개발을 위한 기초 자료로 활용될 수 있을 것으로 기대된다.

CMP용 리테이닝 링의 재질이 웨이퍼의 연마성능에 미치는 영향

박기원(Ki-Won Park),김은영(Eun-young Kim),박동삼(Dong-Sam Park) 한국기계가공학회 2020 한국기계가공학회지 Vol.19 No.3

This paper investigates the effects of retaining ring materials, particularly PPS and PEEK, used in the CMP process, on wafer polishing and ring wear. CMP can be performed using bonded type retaining rings made with PPS or injection molding type retaining rings made with PEEK. In this study, after polishing a wafer with a PPS retaining ring, the average profile height of the wafer was 0.098 μm less than that of the wafer polished with a PEEK retaining ring, implying that PPS retaining rings achieve a higher polishing rate. In addition, the center area of the wafer profile had less deviation and improved flatness after polishing with the PPS ring. These results indicate that a higher polishing rate and smaller profile height deviation can be achieved using retaining rings made with PPS compared to retaining rings made with PEEK. Therefore, with semiconductor circuit patterns becoming finer and wafer sizes becoming larger, the use of PPS in CMP retaining rings can obtain more stable wafer polishing results compared to that of PEEK.

무선 모니터링 시스템의 안테나 출력별 유효거리 평가

박기원(Ki-Won Park),변용훈(Yong-Hoon Byun),최창호(Chang-Ho Choi),이종섭(Jong-Sub Lee) 한국지반환경공학회 2012 한국지반환경공학회 학술발표회논문집 Vol.2012 No.9