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한국과학재단의 생명과학분야 기초연구지원 추이분석을 통한 연구활동지원 활성화 제언
민태선,김성용,조순영,정순욱,한인규,Min Tae-Sun,Kim Seong-Yong,Cho Soon-Yeong,Jeong Soon-Wook,Han In-Kyu 한국생명과학회 2005 생명과학회지 Vol.15 No.1
본 연구에서는 생명과학분야의 연구활동 활성화에 기여코자 생명과학 분야의 연구비 지원 추이와 현황을 파악하여 생명과학분야 연구활동 활성화를 위한 방향을 제시하고자 과학재단 연구비 수혜자를 중심으로 자료를 분석하였다. 생명과학 분야에서는 개인단위보다는 집단 및 그룹단위 형태의 연구에 더 많은 연구비가 투자되고 있는 것으로 조사되었으며, 생명과학 분야의 단위과제당 연구비 수준은 전체 이공계의 연구비 수준에 비교해서 상대적으로 약간 낮은 수준$(2003년,\;88.0\%)$이었다. 각 세부분야별로 연구비지원액 및 지원과 제수를 기준으로 살펴볼 때, 기초의약학 분야의 약진이 두드러진 반면에 농수산 및 생물분야는 감소추세인 것으로 나타났다. 생명과학 분야의 연구활동 활성화를 위해서는 중 $\cdot$장기 연구전략계획 수립, 생명과학전문인력 DB구축과 타 분야 연구진 또는 생명과학 세부분야간의 연계 활용, 전략적 연구지원 분야의 도출 및 절정 연구지원단가 산출, 생명과학 기초연구 특별프로그램 개발, 학회 내 정책기획 분과 신설, 평가문화의 개선 및 생명과학 연구활동의 계량적 성과 지표 개발 등에 따르는 본 분야의 연구지원을 위한 시스템의 구축과 활용이 필요하다. This research was conducted to make suggestions for the promotion of research activities in the Life Sciences field, and we evaluated the research funding trend and the present status of research funding offered by KOSEF in this field. Researchers in this field have received more research funding from the group-based programme than from the individual-based programme. Also, they have received less money (per project) than did researchers in other Science and Technology fields. The portion of research funds given to the Medical Sciences fields has markedly increased year by year, whereas the portion of funding given to the Agricultural Sciences and Biological Sciences fields has decreased annually. To encourage research activities in the Life Sciences field in Korea, the following actions and systems are required: 1) formulation of a mid-and a long-term research master plan, 2) development of a database on man power in related fields, 3) activation of top-down research topics, and associated increase of individual research grants, 4) development of special national programs for basic researches in Life Sciences, 5) organization of a committee for policy and planning within related societies, and 6) system development for fair evaluation of the results of research activities.
민태선 ( Tae Sun Min ),박민정 ( Min Jung Park ),문재학 ( Jae Hak Moon ),김월수 ( Wol Soo Kim ),이상현 ( Sang Hyun Lee ),조영돈 ( Young Don Cho ),박수현 ( Soo Hyun Park ) 한국응용생명화학회(구 한국농화학회) 2013 Journal of Applied Biological Chemistry (J. Appl. Vol.56 No.2
배는 전세계적으로 많이 소모되고 있는 과일이다. 일반적으로 배는 아시아 배와 유럽 배로 분류된다. 배는 다양한 생리활성 물질을 보유하는 것으로 알려져 있으며 이에 대한 기능성 연구가 계속 되어져 진행되고 있다. 따라서 본 종설에서는 지금까지 알려진 배의 생리활성 물질들의 개요 및 다양한 질병들에 대한 예방효과에 대해서 알아보고자 하였다. Pear (Pyrus spp.) fruit has been widely consumed fruits in the world. Pears are generally classified as Asian pears (Japanese pear: Pyruspyritolia N, China pear: P. ussuriensis M) and European pears (Pyrus communis L.). Pears have been reported to contain the diverse bioactive substances and the study on screening for bioactive compounds and its functional role in pear has been still going on. Therefore, this review article provides an overview of bioactive compounds and physiological effects of pears on diverse diseases.
한국과학재단의 농수산분야 기초연구지원 추이분석을 통한 연구활동지원 활성화 제언
민태선 ( Tae Sun Min ),최형균 ( Hyung Kyoon Choi ),김성용 ( Seong Yong Kim ),배승철 ( Sung Chul C. Bai ),김유용 ( Yoo Yong Kim ),양문식 ( Moon Sik Yang ),정봉현 ( Bong Hyun Chung ),황준영 ( Joon Young Hwang ),한인규 ( In Kyu Ha 한국응용생명화학회(구 한국농화학회) 2005 Applied Biological Chemistry (Appl Biol Chem) Vol.48 No.1
An Analysis on Research Funding of Geosciences in Korea
김성용,허철호,민태선,Kim, Seong-Yong,Heo, Chul-Ho,Min, Tae-Sun The Korean Society of Economic and Environmental G 2007 자원환경지질 Vol.40 No.6
This study analyzed trends in geoscientific research funding provided by the Korea Science and Engineering Foundation (KOSEF) and examined strategies to promote geoscientific research. The strengths of geoscientific research in South Korea include the excellent academic quality of researchers, established research infrastructure, and inter-disciplinary research. Weaknesses include insufficient leadership in related societies and institutes, insufficient research productivity, and the exclusion of the field from nationally supported large-scale research projects. Opportunities for expanded research include environmental issues, the sustainable use of natural resources, the promotion of international research cooperation, and the initiation of national efforts to find solutions for regional problems. However, growth in the geosciences is threatened by prioritized investment in fields such as biotechnology, nanoscience, and information technology, a dismissive attitude toward the growth of basic sciences, and an increased demand for projects with visible economic and societal impacts. In terms of funding, group-based programs receive more support than individual-based programs. Between 1978 and 2006, KOSEF invested 1,744 billion won ($1.873 billion US) in a total of 46,748 basic research projects. Of this amount, 62.1 billion won ($66.7 million US) was allocated to 1,901 projects in the geosciences, which was roughly 2.6-10.6% of the money available in a given year. These funds were used to support research and development, the development and maintenance of necessary infrastructure, and the education and training of geoscientists.
신원기,박문기,김다현,장현주,민태선,Shin, Won-Gi,Park, Moon-Ki,Kim, Da-Hyeon,Jang, Hyun-Ju,Min, Tae-Sun 한국환경과학회 2020 한국환경과학회지 Vol.29 No.3
Technology used by human beings has developed drastically over the years. Although people enjoy affluent lives as a result of this development, the depletion of resources has brought about a variety of environmental problems such as emission of fine dust, treatment of waste water, and global warming. Although studies on environmental pollution are being conducted continuously, there are a limited number of studies that analyze research trends from quantitative and qualitative perspectives. In order to examine the current research landscape, we employed Scopus to combine research interest in environmental science with bibliographic analysis. Among 74,089 papers published in 57 journals of environmental science, 3,212 papers were published by Korean authors and citations per publications and Field-Weighted Citation Impact (FWCI) of those papers were 7.3 and 1.0, respectively. By assessing the bibliometric indicators in the field of environmental science, this study provides insight into research trends and related data to aid researchers in developing research strategies.
감마선 조사에 의한 발생과정 중인 마우스의 소뇌발달에 관한 연구
박일권,이경열,박오성,김성화,이근좌,이강이,민태선,육홍선,변명우,김무강,Park, Il-Kwon,Lee, Kyoung-Youl,Park, O-Sung,Kim, Sung-Hwa,Lee, Guen-Jwa,Lee, Kang-Yi,Min, Tae-Sun,Yook, Hong-Sun,Byun, Myung-Woo,Kim, Moo-Kang 대한수의학회 2005 大韓獸醫學會誌 Vol.45 No.2
In order to study about the lobule and layer formation and cell migration of the mouse cerebellum from at the birth to 15th day effected by 2.5, 5 and 10 Gy r-raddiation at the 19th pregnancy. The routine tissue preparation and staining procedure, Immunohistochemical staining method by the several antibody and western brotting method were utilized from the birth to the15th day. The results were as followings. 1. The body and cerebellum weights were more slowly increase of the the 2.5 Gy, 5 Gy and 10 Gy irradiation group compare to the control group, and the health condition of the 2.5 Gy group was a little bad. but the 10 Gy group was more severe and begun to die from the 12th day after birth. 2. The thickness, proliferation and migration of the 2.5, 5 and 10 Gy irradiated external granular cells from the maginal zone to the medullary area forming the molecular layer from the 6th day to the 15th day after birth were thinner, weaker and more slower according to the radiated dosages than the control group in the cresyl violet staining. 3. The proliteration, migration and lobulation of the 5 Gy radiated groups from the first day to the 15th day after birth were more weak, incomplete and irregular shape in the immunostaining with Dab, Cdk5, P35, calbindin and Zebrin antibody. 4. In the western blotting analysis using the Reelin, Dab, Cdk5 and P35 antibody. The Bands were in the 60 KD, 80 KD, 33 KD and 35 KD, and there were no differences between the control and irradiated groups in the molecular band except the Reelin. 5. As a results, the proliferation and migration of the outer granular and purkinje cells, and lobulation of the cerebellum by the several dosaege of the ${\gamma}$-ray radiation were proportionally incomplete according to dosage.
알긴산 분해균 Bacillus licheniformis AL - 577가 생산하는 균체외 효소의 정제 및 특성
어명희(Meung-Hee Uo),주동식(Dong-Sik Joo),조순영(Soon-Yeong Cho),민태선(Tae-Sun Min) 한국식품영양과학회 2006 한국식품영양과학회지 Vol.35 No.2
알긴산을 선택적으로 분해하는 Bacillus licheniformis AL-577 균주가 생산하는 균체 외 효소를 정제하고 특성을 밝혔다. CM-Cellulose, DEAE-Sepharose 및 Gel 크로마토그래프 등의 순서대로 정제하여 정제도가 약 98배 정도인 효소를 얻었다. 정제효소의 활성 최적 pH 및 온도는 6.0 및 35℃이었고, pH 5.5이하와 pH 9.5이상의 반응조건에서는 불안정하였으며, 20℃이상의 온도에서는 불활성화가 쉽게 일어나는 효소였다. 얻어진 효소를 SDS-PAGE로 분자량을 측정한 결과 25,500 Da으로 추정되었다. NaCl 0.2 M 농도에서 최대의 활성을 나타내었고, 무첨가시에도 활성은 약간 나타내었다. Cu²+, Fe²+, Mg²+, Zn²+ 등과 같은 2가 금속이온에 의해서는 활성이 현저히 억제되었고, K+, Li+ 이온에 의해서 활성이 촉진됨을 알 수 있었다. 화학약품인 dithiothreitol와 O-phenanthroline의 첨가로 인하여 약간의 활성 증가를 가져 왔으며 반면 EDTA, L-cysteine는 현저하게 감소하였다. 이 효소는 알긴산에만 특이적으로 작용함으로써 본 효소는 alginase 또는 alginate lyase인 것으로 판단되었다. The extracellular enzyme alginase produced by Bacillus licheniformis AL-577 was purified by ion chromatography on CM-Cellulose column, DEAE-Sepharose column, and followed by gel filtration on Sephadx G-100 column. The optimum pH and temperature for the activity of the purified enzyme were 6.0 and 35℃, respectively. The enzyme was stable at the pH range of 6.0~9.0 and at 20℃. The molecular weight of the enzyme was estimated to be about 25,500 daltons by SDS-polyacrylamide gel electrophoresis. NaCl was required for high activity of the enzyme. The enzyme was inhibited by Ba²+, Co²+, Cu²+, Fe²+, Mg²+, Zn²+, NH₄+, EDTA, L-cysteine, and 2-mercaptoethanol, while stimulated by DTT, O-phenanthroline, K+ and Li+. This enzyme was proposed to be an alginase specifically degrading alginic acid.