甘松香 (감송향)이 아토피樣 (양) 피부염에 미치는 영향

민들레,박은정,Min, Deul-Le,Park, Eun-Jung 대한한방소아과학회 2012 대한한방소아과학회지 Vol.26 No.2

Objectives NJ is being used to treat inflammatory diseases in Korea. In this study, we attempted to evaluate the effects of NJ on atopic dermatitis (AD)-like lesions and mast cell-mediated allergy inflammation in vivo and in vitro. Methods and Results We investigated to ascertain the pharmacological effects of NJ on 2,4-dinitrofluorobenzene (DNFB)-induced allergic reactions under in vivo conditions. Additionally, to find possible explanations for the anti-inflammatory mechanisms of NJ, we evaluated the regulatory effects of NJ on the level of inflammatory mediators in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). Conclusions NJ inhibited the production of the inflammatory cytokines (IgE, IL-6, IL-8 and TNF-${\alpha}$) significantly in vivo and in vitro.

아토피 피부염 외용제에 관련된 국내 임상 및 실험 논문 고찰

민들레,박은정,강경하,Min, Deul Le,Park, Eun Jung,Kang, Kyung Ha 대한한방소아과학회 2013 대한한방소아과학회지 Vol.27 No.1

Objectives The goal of this review is to investigate clinical and experimental studies on external application treatment for atopic dermatitis in Korean literature and to propose for the better method of clinical studies in order to seek more effective treatment. Methods Electronic researches were performed with KTKP, OASIS, National Assembly Library, Korean Medicine Database, KISS, DBpia, and KISTI. Results and Conclusions In Twenty six studies, the numbers of clinical and experimental studies are respectively 10 (38.46%) and 16 (61.54%). The numbers of studies that used herbal complex were 20 (76.92%), and out of that, 6 studies had used a single herbal medicine (23.08%). The external application with oriental medicine for the atopic dermatitis used with Phellodendri Cortex (7), Sophorae Radix (6), Scutellariae Radix (6), Lonicerae Flos (5), Coptidis Rhizoma (5) and so on. Among the clinical studies, the 5 studies were double-blind and randomized-controlled study (50%). The numbers of studies that used Hanifin and Rajka Diagnostic Criteria (1980) were 6 (60%), and that used the Diagnostic Criteria in Korean Atopic Dermatitis (2005) were 4 (40%). Among the clinical studies, categories to evaluate of atopic dermatitis are respectively SCORAD Index (80%), Total IgE (80%), Eosinophil count (70%) and so on. All of the clinical studies (100%) showed a statistically significant decline in atopic dermatitis according to the SCORAD Index, Modified SCORAD Index, the Clinic index score. Among the experimental studies, the numbers of studies that used NC/Nga mice were 9 (56.25%), and out of that 5 studies used BALB/c mice (31.25%). Most of the studies (68.75%) used DNCB as allergy inducing materials. The scales for evaluation of atopic dermatitis were Clinical skin severity score, Histopathologic examination, Immunohematologic examination, safety test and so on. In 12 cases (75%) of experimental studies, the IgE level of experimental group showed a statistically significant decline after using external application. In 8 study cases (50%), Clinical skin severity score of experimental group showed a statistically significant decline after using external application.

당귀음자가감방(當歸飮子加減方)과 외치법(外治法)을 병용한 소아(小兒) 건선(乾癬) 치험 1례

민들레,장성진,박은정,Min, Deul-Le,Chang, Sung-Jin,Park, Eun-Jung 대한한방소아과학회 2012 대한한방소아과학회지 Vol.26 No.3

Objectives The purpose of this case study is to report the effect of concurrent administration of Danguieumja-gagambang and external treatments on childhood psoriasis. Methods The subject is a child with psoriasis. This patient was treated with oriental herbal medicine (Danguieumjagagambang) and external treatments. The improvement of the skin condition is observed by Psoriasis Area and Severity Index (PASI) score. Results After the treatment, the symptoms of psoriasis were relieved. PASI score of this child went down from 4.7 to 0. Conclusions This study showed that concurrent administration of Danguieumja-gagambang and external treatments can be an effective choice for psoriasis.

A Study on the Variation of Hazardous Pollutant Emissions in Korea: Focused on Substances for Emissions Reduction Plan

민들레,김보경,이청수,임지영,윤준헌 환경독성보건학회 2022 한국독성학회 심포지움 및 학술발표회 Vol.2022 No.5

영유아 아토피피부염 환자 69명의 한의학적 치료효과에 대한 후향적 연구

민들레,한명화,박건,서산,한수련,Min, Deul Le,Han, Myeong Hwa,Park, Gun,Seo, San,Han, Su Ryun 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.3

Objectives The purpose of this study is to report the effectiveness of Korean medicine treatment on 69 infant and young child atopic dermatitis patients. Methods 69 infants and young child atopic dermatitis patients who had visited oriental medical clinics from 2011.1.9 to 2012.1.31 were studied. All of them were continually treated for 3 to 9 months, and were analyzed by Objective SCORAD Index (OSI). A detailed analysis of OSI was done according to gender, age, using of topical steroid ointment, family history of atopic disease, treatment period, and intensity. Results 1. Male and female percentage of the study group was 56.5%: 43.5%. The average period of treatment was 6.09 months. 71.0% used topical steroid ointment, and 65.2% had family history of atopic disease. 2. The average period of treatment was significantly longer in patients who used topical steroid ointment, or who had family history of atopic disease. 3. 95.7% of total patients reported decrease in OSI score at the final visit. OSI was significantly lowered after 3, 6, and 9 months of treatment. The longer period of treatment, the lower average post-treatment OSI. 4. 85.5% of the study group had severe dermatitis, and 14.5% was moderate case based on the OSI intensity assessment at initial visit. These percentages got changed at the final visit as 34.8% of severe, 58.0% of moderate, and 7.2% of mild cases. The average treatment period of patients who were diagnosed as severe at the initial visit was 6.18 months, and their final OSI improvement rate was 39.58%. 58% of them were improved to be mild or moderate at the final visit. Conclusion The Korean medicine treatment is effective in treating infant and young child atopic dermatitis patients. There was significant decrease in OSI score after 3, 6, and 9 months of treatment. The difference increase with the treatment period.

동의보감(東醫寶鑑) 소아문(小兒門) 처방(處方)에 대한 고찰(考察)

민들레,Min, Deul Le 대한한방소아과학회 2016 대한한방소아과학회지 Vol.30 No.2

Objectives The purpose of this study is to find a way to apply current oriental pediatrics treatment guidelines based on a pediatric chapter in DongEuiBoGam. Methods I learned pediatrics prescription formula, indications of drugs, dosage regimen from DongEuiBoGam, and I classified herbs that can be used for pediatrics prescriptions based on their types, effects, tempers, flavors, toxicities, and attributive channels. Results & Conclusions I learned similarities among pediatrics prescription regimens and the herbs commonly used in pediatrics. Also, I found out physiological and pathological characteristics in pediatrics. I expect that this study would be helpful for current oriental pediatric treatments.

간호대학생의 환자안전 역량에 영향을 미치는 요인

민들레,곽은주,박승미 한국간호교육학회 2022 한국간호교육학회지 Vol.28 No.3

Purpose: The purpose of this study is to identify nursing students' level of critical thinking disposition, communication skills, and self-leadership and to identify factors that affect the patient safety competency of nursing students. Methods: This study employs a descriptive research, method and was conducted from April 20 to May 19, 2022, with students from three nursing colleges in Korea. The collected data were analyzed by frequency and percentage, independent t-test, Pearson's correlation coefficients, and multiple regression. All analyzes were conducted using IBM SPSS 22.0. Results: The results of the multiple regression analysis showed that the regression model was significant (F=17.30, p<.001) and that communication skills (β=.22, p=.001), self-leadership (β=.31, p<.001), patient safety education experience (β=.15, p=.009), and subjects for credit (β=.15, p=.006) explained 28.0% of nursing students' patient safety competency. Conclusion: It is necessary to develop a self-leadership and communication skills improvement program and to organize rgular courses safety education subjects to improve the patient safety competency of nursing students.

붉은 양배추와 마늘종 추출물의 항산화 및 항균활성 평가와 냉장저장 중 돈육패티에 이용

민들레,박성용,진구복,Min, Del-Re,Park, Sung-Yong,Chin, Koo-Bok 한국축산식품학회 2010 한국축산식품학회지 Vol.30 No.2

This study was carried out to investigate antioxidative and antimicrobial activities of ethanol extracted garlic stem and red cabbage, and their application to pork patties during refrigerated storage. Total phenolic compounds of ethanol extracted garlic stem and red cabbage were 3.13 g/100 g and 3.99 g/100 g, respectively. 1,1'-diphenyl-2-picryhdrazyl (DPPH) radical scavenging activity of garlic stem extracts increased up to 0.05%. Iron chelating activities of both garlic stem and red cabbage increased up to 0.5%, and red cabbage up to the concentration of 1% had similar iron chelating activity to those of EDTA. Pork patties containing garlic stem had higher Hunter L and b values, (p<0.05), whereas those with red cabbage had highest Hunter a values, resulting in similar value to those of control (p>0.05). Thiobarbituric acid reactive substances (TBARS) of pork patties with garlic stem were lower than those of the control (p<0.05). In addition, antioxidantive activities of pork patties with red cabbage were higher than those with garlic stem. No differences in microbial contents were observed between the control and treatments. In conclusion, garlic stem and red cabbage extracts might be used as natural antioxidants to be used in the manufacture of functional meat products.

Gestational diabetes and breastfeeding-related pain as major contributors to early breastfeeding cessation

민들레,곽은주,박승미 한국지역사회간호학회 2023 지역사회간호학회지 Vol.34 No.1

Purpose: This study aimed to determine the effects of gestational diabetes mellitus, breastfeeding-related pain, and infant growth on the cessation of breastfeeding. Methods: This is secondary data analysis. This study included 60 pregnant women from 3 prenatal breastfeeding clinics. Pregnant women aged 20–49 years, with or without a diagnosis of gestational diabetes mellitus were enrolled. The participants were administered four self-reported questionnaires, one at 5 days, 14 days, 3 months, and 6 months postpartum. A linear mixed model and Cox regression analysis were used. Data were collected between May 25, 2020 and June 14, 2021. Results: The rate of breastfeeding cessation was 55.0% (n=33). The average maternal ages were 32.30 (±4.61) and 31.33 (±7.05) years in the cessation and maintenance groups, respectively. The average duration of breastfeeding in the cessation group was 56.27 (±37.48) days. After adjusting for all covariates, the risk of breastfeeding cessation was 2.5 times greater among participants diagnosed with gestational diabetes mellitus (p=.042). Additionally, the risk of breastfeeding cessation was 1.3 times greater among those with severe breastfeeding-related pain (p=.015). Conclusion: The first two months postpartum is the most essential time for healthcare workers to provide support and address difficulties associated with breastfeeding for mothers with gestational diabetes mellitus.

배경대기 수준 일산화탄소 표준물질 개발

민들레,임아랑,문동민,이진복,이동수,김진석 한국대기환경학회 2010 한국대기환경학회 학술대회논문집 Vol.2010 No.10월