http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hgcl2 에 의한 다클론성 활성화에 의해 나타나는 생쥐의 면역반응 변화에 미치는 파치균 다당류의 영향
문창규(Chang Kiu Moon),목명수(Myung Soo Mock),전선덕(Sun Duck Chun),김진형(Jin Hyoung Kim),김강석(Kang Suk Kim),최청하(Chung Ha Choi),황지원(Ji Won Whang) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.4
Repeated injections of low-doses of mercuric chloride in rats or mice induce polyclonal activation which includes the induction of anti-glomerular basement membrane (GBM) antibodies and circulating immune complex and it results in nephritis. Because this disease is autoimmune mediated disease resulted from immune dysfunction, immunomodulators are used to control the symptoms or to cure the disease. Irpex lacteus Fr. is a kind of new medicinal fungus. The polysaccharide fraction extracted from submerged fermentation of Irpex lacteus Fr. decreased the serum agglutinin, serolysin and IgM plaque forming cells in normal mice. The hitherto obtained clinical results suggested that it significantly improved the oligourea, edema, and hypertension in patients who have nephritis. To elucidate the action-mechanisms of Irpex lacteus Fr., we established the experimental model of HgCl₂ induced polyclonal activation by intraperitoneal administrations of HgCl₂ to mice. To assess the immunomodulating effect of lrpex lacteus fraction, we investigated its effects on the mitogen induced proliferation and IgM PFC counts of splenic lymphocytes in mice during the treatment of HgCl₂. The Irpex lacteus polysaccharide reduced the abnormally increased mitogen induced lymphocyte proliferation and IgM PFCs to almost normal levels. And the Irpex lacteus polysaccharides prevented the increasement of serum immunoglobulin level induced by HgCl₂. These data suggested that the Irpex lacteus polysaccharides might have the immunomodulating activity to prevent and /or improve the HgCl₂ induced autoimmune disease.
한국산 식물중 Polyacetylene계 화합물의 검색(Ⅱ)
문창규(Chang-Kiu Moon),김영일(Young-Il Kim) 한국생약학회 1976 생약학회지 Vol.7 No.2
Seven species of Umbellifer-plants and five Compositae-plants were examined for the presence of polyacetylenic compounds. By using the UV-and IR-spectrometric technique combined with preparative T.L.C., the presence of polyacetylenic compounds was identified in Heracleum moellendorffi HANCE and Aster scaber Thunberg.
한국산 식물중 Polyacetylene계 화합물의 검색(I)
문창규(Chang Kiu Moon),윤미훈(Mi Hoon Yoon) 대한약학회 1976 약학회지 Vol.20 No.1
Fourteen species of umbelliferae-plants grown in Korea were examined for the presence of polyacetylenic compounds. By using the UV and IRspectrometric technique combined with TLC, the presence of polyacetylenic compounds was identified in Phellopterus littoralis BENTHAM Peucedanum japonicum THUNBERG and Angelica koreana MAXIMOWITZ.
Lewis Lung Carcinoma(LLC) 이식 생쥐에 있어서 천연운지 단백다당체(Copolang)의 면역조절활성
문창규(Chang Kiu Moon),임철홍(Cheol Hong Lim),목명수(Myung Soo Mock),양경미(Kyung Mee Yang),한혜승(Hye Seung Han),최재영(Jae Young Choi) 대한약학회 1993 약학회지 Vol.37 No.1
Immune functions of mice bearing Lewis Lung Carcinoma (LLC) were significantly suppressed when evaluated with mitogen responsiveness, IL-2 production and non-specific suppressor activity. Based on these immunosuppressive characteristics of LLC bearing mice, immunomodulating activates of Copolang were investigated in this model. After 15 days of LLC inoculation, Copolang was intraperitoneally administered for 7 consecutive days with doses of 20 or 200 mg/kg. Immune functions were evaluated 3 days after the final administration of Copolang. The results showed that the growth of LLC solid tumor was not inhibited by Copolang. But, mitogens-induced proliferation, IL-2 production and responsiveness to recombinant IL-2 of splenocytes were significantly augmented by the treatment of Copolang. However suppressor cell activity was not affected by Copolang. These results indicate that Copolang expresses potent immunomodulating activates through the augmentations of IL-2 production and responsiveness to recombinant IL-2, which have been generally known to be suppressed in tumor bearing mice, without affecting the growth of tumor.
육창수(Chang Soo Yook),이우철(Woo Tchul Lee),문창규(Chang Kiu Moon) 대한약학회 1989 약학회지 Vol.33 No.2
The drug consists of the dried entire plant of Viola diamantica (family Violaceae). It is used for the treatment of acute pyogenic diseases such as boil and carbuncles; also as tumor, high fever, tuberculosis and astringent hemostatic. Two flavonol glycosides have been isolated from the aerial parts of Viola diamantica and could be identifed as kaempferol 7-rhamnoside and kaempferol 3,7-dirhamnoside (bright yellow needle crystal, mp 225o, C27H30044H20). Kaempferol 7-rhamnoside and kaempferol 3,7-dirhamnoside were first isolated from Viola diamantica.
육창수(Chang Soo Yook),문창규(Chang Kiu Moon) 한국생약학회 1985 생약학회지 Vol.16 No.1
금강제비꽃 Viola diamantiaca Nakai의 전초는 청열해독, 지혈, 종기, 출혈, 암, 폐결핵 등에 쓰이는 민간약초이다. 금강제비꽂 메탄올 엑기스에서 5종류의 Flavonoid glycoside를 분리하였다. 그중 하나는 융점 191˚의 담황색 결정으로 FeCl₃에 자갈색, Mg+HCl에 홍색을 띄는 kaempferol-3,7-bisrhamnoside(C_(27)H_(30)O_(14))로 확인하였고 부분 가수분해에 의하여 kaempferol-7-rhamnoside를 얻었다.
육창수(Chang Soo Yook),김현숙(Hyeon Sook Kim),문창규(Chang Kiu Moon) 한국생약학회 1985 생약학회지 Vol.16 No.1
We have studied in order to identify the constituents in the Herba of Viola yedoensis distributed in Korea. Substances (I, II) were isolated and identified by GLG, IR, NMR. They were kaempferal-3-robinoside-7-rhamnoside (m.p. 250∼254˚, C_(33)H_(40)O_(19)) and β-sitosterol.
육창수(Chang-Soo Yook),문창규(Chang-Kiu Moon) 한국생약학회 1981 생약학회지 Vol.12 No.3
The methanol extract of the rootbark of Fraxinus sieboldiana Blume (Oleaceae) gave two coumarin glycosides, fraxin (fraxetin-8-glucoside), C_(16)H_(18)O_(10), mp 204°and esculin (esculetin-6-glucoside), C_(15)H_(16)O<sub>9</sub>, mp 204∼205°. Besides, the methanol extract of the root bark was found to contain mannitol. β-sitosterol is confirmed by massspectrometry.
Ethanol이 Allyl alcohol 독성에 미치는 영향
이주영,김대병,문창규,정진호,Lee, Joo-Young,Kim, Dae-Byung,Moon, Chang-Kiu,Chung, Jin-Ho 대한약학회 1994 약학회지 Vol.38 No.2
Ally alcohol is metabolized in the liver through two steps, first to reactive acrolein by alcohol dehydrogenase(ADH), subsequently to acrylic acid by aldehyde dehydrogenase(ALDH). Since ethanol could compete the same enzymes to be metabolized in the liver, we have studied the interaction between allyl alcohol and ethanol on liver toxicity. Simultaneous treatment of 2 g/kg ethanol by ip administration with 40 mg/kg allyl alcohol to rats increased the lethality significantly, accompanied by potentiation of the loss of hepatic glutathione. Collectively, these findings suggested that ethanol potentiated the hepatotoxicity and lethality induced by allyl alcohol probably through competing two metabolizing enzymes, ADH and ALDH.