인후두 증상 및 후두경 소견으로 인후두 역류를 예측할 수 있는가?

문원 ( Won Moon ),박무인 ( Moo In Park ),김경미 ( Gyung Mi Kim ),김규종 ( Kyu Jong Kim ),박선자 ( Seun Ja Park ),문효성 ( Hyo Sung Mun ),이강대 ( Kang Dae Lee ),김윤정 ( Yoon Jung Kim ),임대관 ( Dae Kwan Lim ),노지훈 ( Ji Hun Roh 대한소화기기능성질환·운동학회 2007 Journal of Neurogastroenterology and Motility (JNM Vol.13 No.1

목적 : 인후두 역류는 아직 잘 이해되지 않고 있으며 아시아인에서 더욱 그렇다. 이에 본 연구자 등은 한국인에서 인후두 역류의 심한 정도와 증상 및 증후들 사이의 관계성에 대해 평가하고자 하였다. 대상 및 방법 : 비흡연자로서 후두 증상을 갖고 reflux symptom index (RSI)로 구성된 증상설문지, 후두경검사를 통한 reflux finding score (RFS), 식도내시경, 식도내압검사 및 24시간 인두 pH 검사를 모두 마친 환자들의 자료를 후향적으로 분석하였다. 결과 : 대상자 52명은 1회 이상의 인후두 역류가 있는 역류 양성군 25명과 27명의 역류 음성군으로 나뉘었다. 양군 모두에서 가장 두드러진 증상은 목소리가 자주 쉬거나 목소리를 내는데 어려움을 느낀다였고 후두경적 소견은 후연합 비대였다. RSI (11점 vs. 14점), RFS (4.8점 vs. 4.9점), 역류성 식도염의 빈도, 식도 괄약근 기저압, 식도연동운동의 양상 모두에서 양군간의 차이가 없었다. 역류 양성군에서 역류횟수의 평균은 9.0회였고 %시간은 1.2%시간이었다. 역류의 심한 정도가 증상 및 증후와 상관성은 없었으나 하부식도 괄약근압과는 역상관 관계가 있었다. 결론 : 한국인에서 인후두 증상 및 후두경 소견은 인후두 역류 유무를 예측할 수 없다. Background/Aims: The pathophysiology of laryngopharyngeal reflux (LPR) is not completely understood yet, especially in Asian people. The aim of this study was to evaluate the relationship between reflux severity and laryngeal symptoms and signs in Koreans. Methods: Non-smoking patients with laryngeal symptoms, who completed reflux symptom index (RSI) questionnaire, laryngoscopic reflux finding score (RFS), esophagoscopy, esophageal manometry and 24-hour pharyngeal pH testing were evaluated retrospectively. Results: Fifty-two patients were enrolled. Twenty-five patients had one or more reflux episodes and were classified as a reflux group (RG) and the remaining twenty-seven as a non-reflux group (NRG). The most predominant symptom was voice problem and predominant sign was posterior commissure hypertrophy in both groups. There was no difference in total scores of RSI (11 vs. 14) and RFS (4.8 vs. 4.9), the rate of reflux esophagitis, the basal pressures of upper and lower esophageal sphincters (PUES and PLES) and the rate of normal peristalsis between RG and NRG. In the RG, the mean number and the %time of pharyngeal acid reflux were 9.0 and 1.2% and none of symptoms and signs were correlated with reflux severity but the reflux number were correlated inversely with PLES. Conclusions: Laryngeal symptoms and laryngoscopic findings did not seem to predict LPR in Korean patients. (Kor J Neurogastroenterol Motil 2007;13:8-14)

SNS 만족도가 소셜커머스 신뢰성 및 지속사용에 미치는 영향에 관한 연구

문종범 ( Jong Beom Moon ),김인섭 ( In Sub Kim ),정원준 ( Won Jun Jung ) 한국경영공학회 2012 한국경영공학회지 Vol.17 No.2

SNS based Social commerce is becoming an issue in our economy and is increasing drastically. Even though there is relatively low entry barrier, the Big three social commerce companies account for more than 50% of the total Korean market. It is required to understand and prepare the characteristics of social commerce when start a new business in social commerce area. In addition, consumer complaints are also increasing due to the relatively low level of services in social commerce. Any social commerce company is not able to provide basic services and it shows a loophole such as customer management. There are these problems in the sales-driven social commerce. Players of social commerce marketplace are divided into consumer, supplier, and seller. This study tried to figure out the relationship among SNS satisfaction, Social Commerce Reliability and Continuous Usage. Based on the results of empirical analysis, we suggests business strategy for social commerce companies. The results of this study can be summarized that there are structural relationship among SNS attitudes, SNS satisfaction, reliability, and continuous use of social commerce. Concretely, SNS attitudes influence to SNS satisfaction and the SNS satisfaction influence to reliability and continuous use of social commerce.

우리나라 암환자의 의료기관 접근성의 지역간 불균형

문연옥(Yeon Ok Moon),박은철(Eun Cheol Park),신해림(Hai Rim Shin),원영주(Young Joo Won),정규원(Kyu Won Jung),황순영(Soon Young Hwang),이진희(Jin Hee Lee),공현주(Hyun Joo Kong),황승식(Seung Sik Hwang),이종구(Jong Koo Lee),공인식(In Sik 한국역학회 2006 Epidemiology and Health Vol.28 No.2

  Objectives: To investigate the differences in accessing regional hospitals and the utilization rate of hospitals located in other regions for cancer patients by regions.   Methods: Data for the utilization of regional hospitals for cancer patients were obtained from the Korean National Cancer Incidence Databases in 1999 and 2002. We divided the regions into 16 provinces by administrative districts. We using the SAS 9.1.3 to analyze difference of regional self-sufficiency and the Arcview 3.2 to show in a schematize for regional variation of the regional self-sufficiency.   Results: There were regional variations in the regional self-sufficiency of cancer patients. Especially, Jeollanamdo(1999 13.6%, 2002 12.8%), Gyeongsangbuk-do(1999 22.0%, 2002 20.7%), and Chungcheongnam-do(1999 27.8%, 2002 27.1%) had low regional self-sufficiency. The regional self-sufficiency in Gyeonggi-do and utilization rate of cancer patients who lived in other regions were increased between 1999 and 2002(regional self-sufficiency: 1999 37.2%, 2002 48.2%).   Conclusion: The results of this study showed that there were regional variation in utilization of regional hospitals for cancer patients. Accessibility of cancer patients in metropolitan areas was higher than in small size cities, medium size cities, and rural county areas. These results suggested that it should be considered support medical facilities for cancer patients in rural areas where have lower relevance rate.

중소제조기업의 글로벌브랜드 전략에 관한 연구

이재원 ( Jae Won Lee ),문종범 ( Jong Beom Moon ),오인하 ( In Ha Oh ),김인섭 ( In Sub Kim ) 한국경영공학회 2013 한국경영공학회지 Vol.18 No.3

There are only 28 companies which grow up from small and medium enterprise to middle standing enterprise for the last 10years in Korea. The SMEs were closed down by large companies that extend a market in all area. In addition, SMEs have poor business environment in comparison with large companies. SMEs are needed to overcome their business environmental situation. SMEs are also needed to expand their market to global markets in order to survive in the future. Moreover, SMEs have to build a global brand competency in the global market. The purposes of this study are as in the following. First, we are to find out factors that influence on global brand-building of SMEs. Second, we tried to verify the impact of global brand on SMEs` global and business performance. The results of empirical test is that the global brand managements influence on the global performance, and global performance influence on the business performance. This result give an implication that it is important for SMEs to obtain global brand competency in order to have continuous competitiveness. Therefore, SMEs can obtain new business opportunity in global market and enhance their global brand image through the continuous global brand management.

학술연구 : 수퍼 가젤형 기업의 특성과 성공요인에 관한탐색적 연구

권오형 ( O Hyeong Kwon ),문종범 ( Jong Beom Moon ),김인섭 ( In Sub Kim ) 한국중소기업학회 2012 기업가정신과 벤처연구 Vol.15 No.2

우리경제에서 중소기업은 사업체 수와 종사자 수에서 상당한 비중을 차지하고 있어 사회경제적으로 중추적인 역할을 하고 있다. 이러한 중소기업의 경쟁력강화는 해당 중소기업뿐만 아니라 우리 경제의 지속적 성장과도 직결되는 중요한 사안이다. 특히 기술력을 바탕으로 한 수퍼 가젤형 기업들은 일반 중소기업에 비해 고부가가치형 기술력의 확보, 높은 생산성과 고수익성, 지속적인 기술혁신활동 등을 통하여 우리 경제의 글로벌 경쟁력을 제고하는데 중추적인 역할을 담당하고 있다. 특히 매출액 1,000억 원을 달성한 수퍼 가젤형 기업들의 경우 국가경제를 떠받치는 새로운 기업군으로 자리매김하였으며, 수출 및 고용창출에도 크게 기여하고 있다. 수퍼 가젤형 기업들은 기존 벤처기업들과는 차별화되는 특성을 가지고 있으므로 발전패턴, 기업특성 및 성공요인에 관한 분석 등에 관한 체계적인 연구를 통하여 지속적인 성장을 위한 정책 마련 및 경영전략 수립의 방향을 제시할 필요성이 대두된다. 또한 소수의 대기업과 다수의 중소기업으로 구성된 호리병형 기업분포를 항아리형 구조로 변화시켜 건전한 산업구조로 전환하는 정책적 노력이 필요할 것이다. 이 같은 상황을 배경으로 본 연구에서는 수퍼 가젤형 기업들에 대한 실태와 현황을 분석하고, 이 중 고성장기업인 수퍼 가젤형 기업들의 핵심 성공요인을 분석하였다. 이러한 핵심 성공요인들을 정부의 지원정책과 향후 벤처기업의 육성에 반영함으로써 수퍼 가젤형 기업의 확대와 더불어 수퍼 가젤형 기업들이 성장하는데 필요한 벤처생태계의 개선 방향을 제시하고 수퍼 가젤형 기업의 바람직한 역할모델을 설정할 수 있는 기초자료를 제시하고자 한다. 또한 우리나라의 경제시스템에서 수퍼 가젤형 기업들이 지속적인 성장을 통한 경제발전과 고용창출에 기여하기 위해 추진해야할 정책적 시사점을 제공할 수 있을 것으로 기대한다. Korean small and medium enterprises take up to 88.1% of Korean economy in terms of the number of company and its employees. It means that small and medium enterprises take an important role as a social and economic backbone. Therefore, strengthening the competitiveness of super gazelle enterprises are a critical subject in Korean economy growth. Unlike ordinary small and medium enterprises, high technology based venture enterprise yields high productivity, high profitability and continuous technological innovation, so they are responsible for central role in the global economy. In the case of the super gazelle enterprises which achieve 100 billion won`s sales record, these enterprises are emerged as new enterprise group which can sustain the national economy and contribute significant portion in exporting products and creating many jobs. Unlike traditional venture, there must be a special management method or strategy performed by super gazelle enterprises. Thus, it is needed to figure out the factors that distinguished from those of traditional venture enterprised through the systemic and practical research. In this study, we analyze actual conditions and status of super gazelle enterprises, especially the key of success factors of these enterprises. The result of this study will be helpful for government to establish venture enterprise`s promotion and support policy, and it will provide the guideline in improving venture ecosystem and the basic data for super gazelle enterprise`s role model. In addition, it will expect that this study provides policy implications for Korean economy development and employment through sustained growth in Korea economic system.

포유동물의 바닥가쪽편도체에서 parvalbumin함유 신경세포에 관한 면역조직화학적 연구

정윤영(Yoon Young Chung),장인엽(In Youb Chang),김종중(Jong Joong Kim),문정석(Jeong Seok Moon),김홍순(Hong Soon Kim),배춘상(Choon Sang Bae) 대한해부학회 2000 Anatomy & Cell Biology Vol.33 No.2

흰쥐, 고양이, 개 및 원숭이의 바닥가쪽편도체에서 면역조직화학방법을 이용하여 칼슘결합단백인 parvalbumin (PV)의 분 포를 조사하였다. 본 실험에 사용한 서로 다른 종에 속하는 포유동물의 바닥가쪽편도체에서 모두 PV에 면역반응을 나타 내는 신경세포와 신경섬유가 관찰되었다. PV 면역반응양성 신경세포들은 대부분 신경돌기에 가시를 가지고 있지 않은 국 소에 전달되는 신경세포의 양상을 띠었으며, 세포체의 모양에 따라 PV 면역반응양성 신경세포들은 주로 세 가지 형태로 나눌 수 있었다. 제 1 형은 구형의 세포체로 세 개 이상의 신경돌기들이 세포체에서 나오는 양상을 띠었다. 제 2 형은 각을 이룬 세포체 모양이거나 전형적인 뭇극신경세포의 세포체 모양을 하며 크기 또한 다양하였다. 제 3 형의 신경세포는 방추형으로 된 세포체의 양끝에서 돌기가 나오는 모양이었다. PV 면역반응양성 신경섬유의 끝부분은 염주 모양을 띠었으며, 바구니 모양의 신경얼기를 형성하고 있었는데 이는 PV가 GABA성 바구니 모양 세포에 분포한다는 것을 암시하는 소견이었다. 결론적으로 포유동물의 바닥가쪽편도체핵에 분포하는 PV 면역반응 양상은 형태학적으로 종간의 차이가 없음을 알 수 있었다. The calcium-binding protein parvalbumin (PV) was localized in the basolateral amygdala of the rat, cat, dog and monkey using immunohistochemical techniques. In all species, neuronal cell bodies and fibers that are immunoreactive to PV were observed in the basolateral amygdala. In most of the amygdala, PV-immunoreactive cells had the appearance of aspiny local circuit neurons. Based primarily on the shape of the soma, PV-immunoreactive aspiny neurons were divided into three main types. Type 1 cells had a spherical soma and more than 3 dendrites, type 2 cells had angular and multipolar somata of variable sizes, and type 3 cells had fusiform somata and dendrites emanated from the opposite poles of somata. PV-immunoreactive varicose fibers formed basket-like plexi around unstained neurons, which suggests that PV is located in GABAergic basket cells, respectively. PV-immunoreactivities in the mammalian basolateral amygdala were morphologically similar, rather than different in all species.

진행성 위암에 대한 1차 요법으로 Docetaxel, Cisplatin, 5-FU 복합화학요법의 효과와 안전성

김부경 ( Bu Kyung Kim ),박무인 ( Moo In Park ),박선자 ( Seun Ja Park ),김규종 ( Kyu Jong Kim ),문원 ( Won Moon ),정수현 ( Su Hyeon Jeong ),김혜수 ( Hye Soo Kim ),남성진 ( Sung Jin Nam ) 대한내과학회 2011 대한내과학회지 Vol.80 No.6

Background/Aims: This study investigated the efficacy and safety of docetaxel/cisplatin/5-fluorouracil (DCF) combination chemotherapy as a first-line treatment in patients with advanced gastric cancer. Methods: The study enrolled 48 patients diagnosed with unresectable pathologically proven gastric cancer who received DCF combination chemotherapy between April 2006 and August 2009. The dose administered was docetaxel 75 mg/m2 for 1 h and cisplatin 75 mg/m2 for 90 min on day 2, and 5-FU 750 mg/m2 for 24 h on days 1-5, every 3 weeks. The response was assessed every three cycles. The toxicity was evaluated for every chemotherapy course according to the National Cancer Institute (NCI) toxicity Results: The median age of the patients was 58 years (range 31-78 years). The median overall survival was 11.5 months (2.3-28.2 months) and the median time to progression was 5.5 months (0.3-18.9 months). No complete remission occurred. Of the patients, 56% achieved a partial response, 21% stable disease, and 10% progressive disease. The overall response rate was 56%. During a total 292 cycles, anemia worse than NCI toxicity grade 3 occurred in 2%, leukopenia in 33.1%, neutropenia in 67.1%, and thrombocytopenia in 4.4%. Neutropenic fever occurred in 33 cycles (11.3%), dose reduction due to side effects in 165 cycles (56.5%), and a regimen change due to side effect in five cycles (1.7%). Conclusions: Combination chemotherapy with docetaxel, cisplatin, and 5-FU is efficacious, but has relatively high toxicity. A DCF protocol that maximizes its efficiency, while minimizing toxicity, would be more useful as a first-line treatment in patients with advanced gastric cancer. (Korean J Med 2011;80:680-686)

감두탕(甘豆湯) 약침액(藥鍼液)이 종양세포(腫瘍細胞)에 미치는 영향(影響)

한상훈 ( Sang Hoon Han ),박인규 ( In Kyu Park ),임창수 ( Chang Soo Lim ),문진영 ( Jin Young Moon ),임종국 ( Jong Kook Lim ) 대한경락경혈학회 2000 Korean Journal of Acupuncture Vol.17 No.1

Gamdutang aqua-acupuncture solution(GAS) and Gamdutang water-extracted solution(GWS) were prepared and tested for potential antitumor activities. It was shown to possess considerable toxicity toward various tumor cell lines. Concentration of 5× and 10× of GAS resulted in more than 70% inhibition of growth in Ehrlich ascites tumor cells(EATC), hepa1c1c7 and A549. GAS at the concentration of 10× and 5× revealed that more than 60% inhibition in HeLa. GWS showed more than 50% inhibition of growth with EATC, HeLa at the concentration of 5× and 10×. Toxicity assay with GWS in hepa1c1c7 and A549 revealed that more than 80% inhibition of growth at the concentration of 5× and 10×. In morphological study, the number of cells were decreased, and the shape of cells was round-form. Most of cells is detached in EATC, Hepa1c1c7, HeLa, and A549 with GAS. These results suggest that GAS has antitumor activity in vitro.

개 앞띠겉질에서 parvalbumin과 calbindin D-28k 양성반응세포의 출생후 발달에 관한 연구

윤상필(Sang-Pil Yoon),안계훈(Gye-Hoon Ahn),문정석(Jeong-Seok Moon),김종중(Jong-Joong Kim),유호진(Ho-Jin You),김진호(Jin-Ho Kim),장인엽(In-Youb Chang) 대한해부학회 2002 Anatomy & Cell Biology Vol.35 No.2

출생시부터 출생후 180일까지 개의 앞띠겉질에서 칼슘결합단백인 parvalbumin과 calbindin D-28k 양성반응세포의 출현 시기, 분포양상, 발생양상을 확립하기 위하여 면역조직화학적 방법을 이용한 실험 결과 다음과 같은 결론을 얻었다. Parvalbumin 면역반응은 출생후 7일에 VI층 뭇극세포에서 처음 관찰되었다. GABA계 사이신경세포에서 parvalbumin 면역 반응은 안쪽에서 바깥쪽으로 퍼져나가는 현상을 보였고, 출생후 180일에 성숙형과 유사한 분포상을 보였다. 면역반응은 주로 발생중인 비피라밋세포에서 나타났으나 parvalbumin에 양성반응을 보이는 V층의 피라밋세포가 출생후 14일부터 90 일까지 일시적으로 관찰되었다. Calbindin D-28k 면역반응은 parvalbumin 면역반응과는 차이가 있었다. Calbindin D-28k 면역반응은 출생시 V층 피라밋세포에서 처음 나타났고, 이 양상은 출생후 90일까지 지속되었다. Calbindin D-28k에 양성반응을 보이는 사이신경세포는 출생시 속과립층 아래 영역과 백색질에 분포하였고, 출생후 14일가 되어서는 속과립층의 위∙아래 영역 모두에서 증가하였으며, 성숙형과 유사한 분포상은 출생후 180일에 확립되었다. 이상의 결과로 미루어 미성숙한 상태의 사이신경세포 뿐만 아니라 미성숙 피라밋세포에서 칼슘결합단백이 일시적으로 발현되는 것은 칼슘의 증가에 의한 손상으로부터 신경세포를 보호하는 칼슘결합단백의 기능과 연관이 있는 것으로 사료된다. We have examined the ontogeny of parvalbumin and calbindin D-28k immunoreactivities in the canine anterior cingulate cortex from the day of birth (P0) through P180. At P7, parvalbumin immunoreactivity appears firstly in layer VI multipolar cells. The parvalbumin immunoreactivity in GABAergic interneurons appears to follow an ‘inside-out’gradient of radial mergence and reaches an adult-like pattern by the end of the 6th postnatal month. Immunoreactivity is limited mainly to developing nonpyramidal cells, whereas pyramid-like parvalbumin immunoreactive cells are transiently observed in layer V from the P14 to the P90. The developmental pattern of calbindin D-28k immunoreactivity differs from that of parvalbumin immunoreactivity. Calbindin D-28k immunoreactivity develops firstly in layer V pyramidal cells from P0, which continues through the third postnatal month. Calbindin D-28k immunoreactive interneurons are located in the infragranular layers and white matter at P0 and increase in both the supragranular and infragranular layers by P14. This is followed by an adult-like pattern at the P180. These data suggested that parvalbumin and calbindin D-28k may play a role in protecting immature neurons from intracelluar calcium influx during postnatal development.

넓은 공극범위에서 소프트스위칭 동작하는 무선전력 충전시스템

문유진(Yu-Jin Moon),우정원(Jeong-Won Woo),김은수(Eun-Soo Kim),황인갑(In-Gab Hwang),원종섭(Jong-Seob Won),강성수(Sung-Soo Kang) 전력전자학회 2022 전력전자학회 논문지 Vol.27 No.6