출혈성 신증후군 환자의 혈장 Atrial Natriuretic Polypeptide 농도 변화

박정의(Jeong Euy Park),차대룡(Dae Ryong Cha),김종웅(Jong Woong Kim),표희정(Heui Jung Pyo),이호왕(Ho Wang Lee),문정식(Jung Sik Moon),황흥곤(Heung Kon Hwang),김대중(Dai Joong Kim) 대한내과학회 1991 대한내과학회지 Vol.41 No.2

N/A Hemorrhagic fever with renal syndrome (HFRS) is characterized clinically by acute renal failure and pathologically by dense hemorrhage in the right atrium and medulla of the kidneys. To investigate whether there is any significant relationship between the changes of plasma atrial natriuretic polypeptide (ANP) and the clinical course, the plasma ANP was measured in 21 patients with HFRS. The plasma ANP was normal to low during the early oliguric phase (94.6±37.0 pg/ml), went up to a very high level (292.4±190.4 pg/ml) at the beginning of diuresis, then fell to a near normal level in a few days. The plasma renin activity (PRA) was very high during the early oliguric phase and fell rapidly in an opposite direction to the plasma ANP as the patients began diuresis. The rapid increase of plasma ANP and decrease of PRA seem to play an important role in the beginning of diuresis in HFRS.

전자빔 기술을 이용한 CO₂ 개질반응 기초연구

이기완 ( Lee Ki-wan ),김조천 ( Kim Jo-chun ),염승열 ( Yum Seung-ryol ),문정식 ( Moon Jeong-sik ) 한국환경기술학회 2000 한국환경기술학회지 Vol.1 No.3

본 연구는 고에너지 전자빔을 이용한 CO₂ 개질 및 자원화 공정의 기초연구로서, 1.5 MeV, 40mA의 선형전자빔가속기를 이용한 PVF재질의 반응기 내에서의 전자빔 CO₂ 개질반응을 실험하였다. 5~10%의 CO₂ 가 함유된 모사가스에 대하여 얻은 실험결과, 전자빔 흡수선량이 클수록 반응율이 높게 나타났고 NH₃양론비는 CO₂ 개질공정의 주요 영향인자이며, 에어로졸형태의 수분첨가는 10~16%의 반응율을 향상시키는 인자로 작용하고 ammonium hydrogen carbonate ammonium carbamate 의 반응 부산물이 얻어짐을 확인할 수 있었다. This is a fundamental study related with CO₂ reforming and recycling of byproducts Using high-energy electron beam. The linear electron beam acclerarator with maximum Energy 1.5 MeV, beam current 40 mA was used for CO₂ reforming of simulated gas in PVF reactor, and simulated gas mixture used in this work are composed 5 to 10% of CO₂ From the experimental results, CO₂ conversion depends on the absorption dose of electron beam, NH₃ stoichiometry is a main factor of CO₂ reforming. Addition of water aerosole in CO₂ reforming elevated the conversion efficience by 10 to 16%. Main components of byproduct from CO₂ reforming are ammonium hydrogen carbonate and ammonim carbamate.

조선시대 인사행정제도에 관한 연구

문정식 한국행정사학회 2001 韓國行政史學誌 Vol.10 No.1

인사행정제도의 역사적 전개는 인류의 역사와 함께 발달하였다. 역사를 구성하는 모든 사건은 적어도 어떤 행태로 든지 인사행정제도에 영향을 미치기 때문이다. 따라서 현대인사행정의 전체적이고 종합적인 연구를 위해서는 우리의 전통적인 인사행정제도에 관한 연구부터 선행되어야 할 것이다. 인사행정제도의 역사적 전개는 인간관계가 발생하면서부터 시작되었다고 볼 수 있다. 본 논문에서는 우리의 전통적인 인사행정제도를 연구함에 있어서 다른 왕조에 비해서 비교적 체제가 잘 갖추어진 조선시대의 인사행정제도를 중성으로 연구하여, 우리의 전통적인 인사행정제도를 고찰함으로서 현재 우리나라의 인사행정제도의 방향을 제시해주는 이정표로 삼고자 한다. 여기서 고찰한 조선시대의 인사행정제도의 내용은 다음과 같다. 첫째, 조선시대 인사행정 기초면 에서는 인사행정법령, 중앙인사행정기관, 등을 살펴보았으며 둘째, 조선시대 관료의 등급제도를 파악하였으며, 셋째, 조선시대의 관료채용방식에 대해서 고찰하였으며, 넷째, 조선시대 관료의 능력발전에 대해서 살펴보았으며, 다섯째, 조선시대관료의 보수제도에 관해서 고찰하였다. 본 논문에서 조선시대 인사행정하의 관료의 성과, 행태는 일일이 설명할 수는 없으나 위에서 검토한 점들을 바탕으로 하여 현재 국가발전의 담당자로서 역할을 수행하고 있는 壽무원의 발전지향적이고, 미래지향적인 행태 변화에 도움이 되었으면 한다.

식도정맥류 출혈에 대한 내시경적 결찰요법과 예방적 결찰요법의 비교

이재학,박홍배,정경헌,김기현,박철성,강명원,문정식,여향순 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.3

Endoscopic Variceal Ligation(EVL) was developed as an alternative to endoscopic injection sclerotherapy(EIS) for decreasing of complication rate. This new technique involves placement of small elastic O-rings around the variceal channels in the distal esophagus. To evaluate the efficacy of EVL for treatment of the acute bleeding esophagea1 varices and the efficacy of prophylactic EVL, we compared EVL in 88 patients who had recently bled from esophageal varices(Group 1) and prophylactic EVL in 45 patients with large size(Grade 2 or 3 or 4) and red color sign on endoscopic finding who had not previously had upper gastrointestinal bleeding(Group 2). Also, we compared prophylactic EVL group(Group 2) and control group(Group 3) who did not performed EVL. At the time of treatment 28.4%(25/88) of patients had active bleeding. They were all treated acutely with EVL and repeated treatment for the long-term goal of variceal eradication. Initial hemostatic efficacy of EVL for acute bleeding varices was 92%(23/25). Varices were eradicated or reduced to Grade 1 in 68%(17/2S). Early mortality rate within 2 weeks was 8%(2/25). Among patients who had eradicated or reduced to Grade 1 varices by repeated EVL sessions, over a mean follow-up of 11 months there was no difference between Group 1 and Group 2 in recurrent rate(49.1%(27/63) vs. 46.8% (15/32)), rebleeding rate(10.9'Yo (6/55) vs. 9.3% (3/32)), rebleeding interval(average 75 days vs, 83.6 days). There was significant difference between prophylactic EVL group and con- trol group in bleeding rate(9.3%(3/~32) vs. 43.7%(14/32))~(p$lt;0.05). Three patients(6.6%) died in prophylactic EVL group, two from ligation site bleeding of esophageal varix, one from hepatic failure. In conclsion, EVL is an effective method for treatment of acute bleeding esophageal varices with repeated sessions. Although prophylactic EVL can be used to prevent bleeding by eradication with lower initial morbidity are necessary because of EVL-related complications.

갑상선 결절에서 T1-201 주사의 진단적 의의

김순호,임중규,정경헌,김기현,박철성,문정식,이재학,허진득,조형석,손장신 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.2

To investigate diagnostic value of Thallium 201(T1-201) thymid scan in differentiating malignant nodule from benign, 135 patients with thyroid nodule were evaluated with Tl-201 thyroid scan, fine needle aspiration(FNA), clinical characteristics and laboratory data. Each had histological diagnosis after thyroidectomy. Tl-201 scan had a sensitivity of 67.3% and a specificity of 66.3% and FNA had sermitivity of 46.9% and specificity of 100% in predicting malignancy. As the size of thyroid nodule and age of patient incteases, diagnostic value of 11-201 thyroid scan was improved. In the thyroid nodules larger then 3cm, sensitivity, specificity and negative predictive value were 100%, 70% and 100%, reqectively. By cornbining Tl-201 throid scan and FNA, sensitivity had 91.8%. From the data we conclude that Tl-201 thyroid scan is valuable with adjuvant diagnostic method in differentiating malignant fmm benign thyroid nodule and treatment planning(J Kor Soc Endocrinol 11:175~181, 1996).

상부 위장관 및 췌담도계 질환의 내시경적 초음파 단층술 진단 589예

이재학,박홍배,여향순,정경헌,김기현,박철성,강명원,문정식 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.2

Endoscopic ultrasonography (EUS)-a combination of endoscopy a.nd ultrasonography was one of the most useful tools for diagnosis of digestive system diseases. This technique was known to be very effective in the assessment of depth of invasion in gastric cancer and in pancreatico-biliary diseases. We performed EUS in 589 patients with upper gastrointestinal and pancreatico-biliary tract lesion prior to surgery for past 22 months and examined the diagnostic accuracy of EUS, respectively. The results were compared to surgical histology in esophagus and stomach cancer,to concordance witb endoscopic retrograde cholangiopancreatography(ERCP ) results for pancreaticobiliary diseases. 1) In 589 patients diagnosed with EUS, the mean age of the patients was 55.9 years with a male to female ratio of 1.7: 1. 2) Patients were divided into three groups; post-upper gastrointestinal endoscopy, post ERCP and undiagnosed with other diagnostic tools. 3) Among post-upper gastrointestinal endoscopy, 64 cases were operated due to esophageal and gastric cancer and then compared to surgical histology. After compared, EUS accuracy on depth of invasion was 78.1% and sensitivity and specificity on lymph node metastasis in gastric cancer were 76.9% and 74.3%, respectively. 4) In post-ERCP cases, EUS results were compared to ERCP results and then concordance rate was 95.4%. 5) In undiagnosed cases, EUS was performed and results were reported. EUS was very effective in the assessment of depth of invasion n gastric cancer and diagnosis of pancreatico-biliary diseases, respectively.