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만성 B형 간염 바이러스 감염자에서 혈청 HBV DNA 양과 간조직 소견의 관련성
허정호 ( Heo Jeong Ho ),허정 ( Heo Jeong ),권대식 ( Kwon Dae Sig ),문재현 ( Mun Jae Hyeon ),김광하 ( Kim Gwang Ha ),강대환 ( Kang Dae Hwan ),송근암 ( Song Geun Am ),조몽 ( Jo Mong ),양웅석 ( Yang Ung Seog ) 대한소화기학회 2003 대한소화기학회지 Vol.42 No.3
Background/Aims: Serum HBV DNA levels are correlated with hepatic histologic activity in chronic HBV infection based on HBeAg. Liver injury may persist, even though HBV DNA are not detected by hybridization assay. This study was to investigate whether serum HBV DNA levels determined by more sensitive quantitative method are correlated with histologic activities in chronic HBV infections. Methods: This study included 66 chronic HBV infected patients. HBV DNA level was quantified by Cobas Amplicor HBV MonitorTM. Results: Serum HBV DNA levels in HBeAg-positive patients were significantly higher than HBeAg-negative patients. In HBeAg-positive patients, serum HBV DNA levels showed a significant negative correlation with portal-periportal activity and fibrosis (r=-0.451, -0.446 respectively). AST levels were correlated with lobular, portal-periportal activity and fibrosis (r=0.432, 0.365, 0.301 respectively), whereas ALT levels were related to lobular activity (r=0.294). Elevated AST levels predicted lobular activity, portal-periportal activity, and fibrosis with moderate to severe degree (OR 1.733, 95% CI 1.083-2.775; OR 1.518, 95% 1.028-2.243, p=0.336; OR 17.897, 95% CI 1.517- 211.208, p=0.022, respectively). Conclusions: In HBeAg-positive patients, serum HBV DNA level correlates inversely with histologic activity. On the other hands AST level correlates with histologic activity and the stage of moderate or severe degree. (Korean J Gastroenterol 2003;42:220-225)
김동우(Dong-Woo Kim),이기연(Ki-Yeon Lee),채동주(Dong-Ju Chae),문영채(Young-Chae Mun),임승택(Seung-Taek Lim),문재현(Jae-Hyeon Moon),전정채(Jeong-Chay Jeon) 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.10
본 연구에서는 AHP기법을 활용하여 평가 대상 요소를 정량화하는 기법들을 비교·분석하였다. 쌍대 비교행렬로부터 평가 요소를 정량화 하는 방법에는 고유값법, 멱승법, 근사법, 기하법 등이 있다. 이러한 각 기법들에 대한 특징을 쌍대비교 행렬의 일관성 비율에 따라 시뮬레이션을 통해 비교·분석하여 상황에 따라 적절한 방법을 선택하여 의사결정 및 중요도 평가에 적용하도록 하였다.