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Swei세포에서 Ceramide의 c-myc, c-fms 유전자 발현에 대한 작용
문은순,윤기호,최경희,김미영 중앙대학교 약학연구소 1994 약학 논총 Vol.8 No.-
The effect of ceramide on the expression of protooncongences, c-myc and c-fms, has been investigated in Swei cells. Treatment with a synthetic cell-permeable ceramide(N-acetylsphingosine) caused increase in c-fms mRNA in a time-dependent manner. The induction of c-fms gene was detected at 3 hr and the peak effect occurred at 24 hr after the addition of 6μM of ceramide. The expression of c-myc protooncogene was decreased at 1 hr 30 min in Swei cells. Ceramide also inhibited cell growth in a dose-dependent manner in Swei cells. These results suggested that ceramide in involved in the regulation of cell growth.
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文銀順(MOON Eun-soon) 고구려발해학회 2008 고구려발해연구 Vol.30 No.-
The purpose of this research is to examine earthen mound tomb with a stone chamber which became common royal tombs of Three Kingdoms in the 6th∼7th century. The earthen mound tomb with a stone chamber developed from the tomb style of stone chamber with entrance that was a big change in tomb style in ancient East Asia and had a great effect on royal tomb style of all kingdoms in Korean Peninsula. First, I observed Goguryeo’s royal tombs in Pyeongyang which adopted the form of earthen mound tomb with a stone chamber far in advance of Three Kingdoms, and then compared the constructive feature with that of royal tombs of Baekje and Silla which adopted the tombs style in the 6th~7th century By the late-5th century and the mid-6th century, the royal tombs of Three Kingdoms all changed the former tomb styles into the earthen mound tomb with a stone chamber. But there were some differences in their structures in the process of their adopting and developing a new tomb style. Such differences resulted from inheritance of some parts of former tomb style to their new royal tombs. In this situation, Three Kingdoms had been making the typical patterns of royal tombs which had each structural difference by 6th~7th century. Of Three Kingdoms, Goguryeo first adopted the earthen mound tomb with a stone chamber and established the model of royal tombs. Because Goguryeo had experienced advanced culture through China and Nangnang in earlier time and had stone handling skills in the process of using stone mound tomb for a long time. The earthen mound tomb with a stone chamber spread out all parts of East Asia with the change of burial idea because it was a new advanced tomb style in that time and had many advantages in economical efficiency. The standardization of tomb style to the earthen mound tomb with a stone chamber in Three Kingdoms royal tombs, was one of processes changing system in various parts under new ideas in Three Kingdoms undergoing considerable changes.
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고구려(高句麗) 남진과정(南進過程)에 대한 고고학적(考古學的) 연구(硏究) - 평양천도과정(平壤遷都過程)을 중심으로 -
文銀順 ( Moon Eun-soon ) 청계사학회 2006 청계사학 Vol.20 No.-
Scholarly opinion on the main direction of development of Koguryo is divided between northward and southward expansion. It can be said that most research until now has focused on Koguryo’s northward expansion and research concerning southward expansion has been neglected. The process of Koguryo’s southward expansion can be divided into three stages. During the first phase of expansion Koguryo's territory reached the Yalu(Apnok_鴨綠)river. By the end of the second phase, the Taedong river area and by the end of the third phase, Koguryo’s territory expanded to the Han river area. Among the three phases, the move of the capital to Pyongyang, or the phase of expansion to the Taedong river area, has great historical significance concerning Koguryo’s southward expansion. I have examined the international situation during the 4th centuries which became the background of the move of the capital to Pyongyang. The characteristics seen here were the new international situation after the 4th century where China was divided into many contending states. I have examined archaeological relics of the two capital cities of Kuknaesong and Pyongyang, including tomb relics in order to show the changes which took place between the move of the capital from Kuknaesong to Pyongyang. As a result, we have seen that Kuknaesong before the move of the capital to Pyongyang was no longer suited as the capital city because it was too small and overcrowded to serve as the capital city. I have concentrated on the southward expansion of Koguryo, specifically on the move of the capital to Pyongyang, by examining the administration of Pyongyang before becoming the capital city and the background of the move of the capital to Pyongyang. The administration of Pyongyang before the move of the capital began in earnest during the reigns of King Kokukwon and Kwangaeto, which shows that the move of the capital to Pyongyang during the reign of King Jangsu was carefully planned in advance. The external factor of the move of the capital to Pyongyang was the new international situation after the 4th century where China was divided into many contending states. The domestic reason for the move of the capital to Pyongyang was the sudden increase in the area of the capital city, because the number of government officials had increased following the expansion of territory under King Kwangaeto, and a need to bring change in the administration of the ruling apparatus. In response to the external and internal circumstances at the time, the move of the capital to Pyongyang during the 15th year of the reign of King Jangsu(427), was Koguryo's reaction to the above situation.
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관류 흰쥐 간에서 1,2-Dioctanoyl-sn-Glycerol에 의한 글루코오스의 유리작용
황영은(Young Eun Hwang),문은순(Eun Soon Moon),김미영(Mie Young Kim) 대한약학회 1991 약학회지 Vol.35 No.6
The effect of diacylglycerol on glucose release was studied by using 1,2-dioctanoyl- sn-glycerol (diC8), a cell permeable diacylglycerol, in perfused rat liver. The glucose release was increased by diC8(50 mcM), and the effect was depended on calcium ions. The increment of glucose release by diC8(50 mcM) was inhibited by indomethacin (50 mcM); the amount of glucose release was almost the same with that of control group. Arachidonic acid(200 mcM) also increased glucose release and the release was inhibited by indomethacin. There was no synergistic effect on glucose release by the combination of diC8(50 mcM) and phenylephrine(10 mcM).
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