인공해수를 이용한 암컷 뱀장어(Anguilla japonica)의성 성숙유도

문성희,김노영,김동우,윤정희,하지은,권준영 (사)한국해양생명과학회 2021 (사)한국해양생명과학회 학술대회 Vol.2021 No.11

자연생식과 건강

문성희 한국지역사회연구소 2001 지역사회 Vol.38 No.-

겨울을 딛고 새봄을 향하는 PAPER와 닮은 단팥죽

문성희 메이데이 2020 Paper Vol.259 No.-

Expression Patterns of Growth Related Genes in Juvenile Red Spotted Grouper (Epinephelus akaara) with Different Growth Performance after Size Grading

문성희,유진호,오현지,이치훈,백혜자,이영돈,권준영 한국발생생물학회 2019 발생과 생식 Vol.23 No.1

Fish shows great difference in growth rate between individuals during larval development and early growth. This difference seriously reduces the production efficiency in fish culture. Growth hormone (GH)/Insulin-like growth factor 1 (IGF1) system is said to play some pivotal roles in fish growth. In this study, we investigated differences of GH, IGF1 and GHR gene expressions in juvenile red spotted grouper (Epinephelus akaara) with different growth performance. Red spotted groupers were reared under the same environmental condition (water temperature 24±1℃, natural light) for 96 days after hatching. They were divided into 3 groups by size (fast growing, middle growing and slow growing groups: FGG, MGG, and SGG, respectively). RNA was extracted from the brain, liver and muscle tissues from each group, and target gene expression was examined by real-time PCR. In the brain with pituitary gland, expression of GH gene in FGG was significantly higher than the expression in SGG, but the expression of IGF1 and GHR genes in the muscle was highest in SGG. Difference of GHR and IGF1 mRNA in the liver between groups with different growth performance was less clear than that in other tissues, although level of IGF1 mRNA was higher in SGG than in MGG. These results suggest that hormonal governing of growth is not the same in fast growing and slow growing fish, and size grading could cause a shift of hormonal state and growth pattern in this species.

FACES Ⅲ와 family APGAR지수와의 연관성

문성희,전종찬,오현경,김해연,배철영,신동학 대한가정의학회 1993 Korean Journal of Family Medicine Vol.14 No.1

Breast Metastases from Extramammary Malignancies: Typical and Atypical Ultrasound Features

문성희,고은영,한부경,신정희,김숙정,조은윤 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.1

Breast metastases from extramammary malignancies are uncommon. The most common sources are lymphomas/leukemias and melanomas. Some of the less common sources include carcinomas of the lung, ovary, and stomach, and infrequently, carcinoid tumors, hypernephromas, carcinomas of the liver, tonsil, pleura, pancreas, cervix, perineum, endometrium and bladder. Breast metastases from extramammary malignancies have both hematogenous and lymphatic routes. According to their routes, there are common radiological features of metastatic diseases of the breast, but the features are not specificfor metastases. Typical ultrasound (US) features of hematogenous metastases include single or multiple, round to oval shaped, well-circumscribed hypoechoic masses without spiculations, calcifications, or architectural distortion; these masses are commonly located superficially in subcutaneous tissue or immediately adjacent to the breast parenchyma that is relatively rich in blood supply. Typical US features of lymphatic breast metastases include diffusely and heterogeneously increased echogenicities in subcutaneous fat and glandular tissue and a thick trabecular pattern with secondary skinthickening, lymphedema, and lymph node enlargement. However, lesions show variable US features in some cases, and differentiation of these lesions from primary breast cancer or from benign lesions is difficult. In this review, we demonstrate various US appearances of breast metastases from extramammary malignancies as typical and atypical features, based on the results of US and other imaging studies performed at our institution. Awareness of the typical and atypical imaging features of these lesions may be helpful to diagnose metastatic lesions of the breast.

소아 유행성 무균성 뇌막염에서 보이는 장간막 림프절 종대 : 초음파 소견과 임상적 의의

문성희,박영찬,이영환 대한초음파의학회 2006 ULTRASONOGRAPHY Vol.25 No.3

목적 : 여름철 유행성으로 발생하는 소아 무균성 뇌막염에서의 장간막 림프절 종대의 초음파 소견과 그 의의에 대하여 알아보고자 한다. 대상 및 방법 : 무균성 뇌막염으로 진단된 33명의 소아 환자(남자; 25명, 여자; 8명, 평균 연령; 8.6세)를 대상으로 전향적으로 복부 초음파검사를 실시하여 장간막 림프절 종대에 대하여 살펴군(16예, 48%)과 무증상군(17예, 52%) 사이에 림프절의 수와 크기, 그리고 연령을 비교 분석하였다. 결과 : 무균성 뇌막염 33예 중 31예(94%)에서 장간막 림프절 종대를 보였으며, 복통 또는 설사 증상을 동반한 증상군 16예 모두에서, 그리고 무증상군 17예 중 15예(88%)에서 장간막 림프절 종대를 보였다. 커진 림프절의 수는 6-10 개가 16예(52%)로 가장 많았고, 가장 큰 림프절의 단경의 범위는 4-8 mm이었다. 림프절 종대를 보인 31예 중 가장 큰 림프절의 단경은증상군에서 평균 6.0 mm, 무증상군에서 평균 5.0 mm로, 두 군 간의 유의한 차이가 있었으며 (p = 0.021), 커진 림프절의 수와 환자 연령 은 두 군 간 에 통계학적으로 차이가 없었다. 결론 : 여름철 유행성으로 발생하는 소아 무균성 뇌막염에서 장간막 림프절 종대가 대부분 관찰되며, 장 바이러스에 의한 비특이적 장간막 림프절염과 관련되었을 것으로 생각된다. PURPOSE : To evaluate the sonographic features of mesenteric lymphadenopathy in childhood epidemic aseptic meningitis and to assess their clinical significance. MATERIALS and METHODS : Thirty-three patients (25 male, 8 female; mean age, 8.6 years) with a diagnosis of aseptic meningitis were prospectively evaluated with abdominal ultrasonography for the presence of enlarged mesenteric nodes. The size and number of enlarged mesenteric lymph nodes were analyzed in relationship with the patient’s age, between the patients with abdominal pain or diarrhea (16 cases, 48%) and asymptomatic patients (17 cases, 52%). RESULTS : Mesenteric lymphadenopathy was seen in 31 patients (94%), all 16 symptomatic and 15 of the 17 asymptomatic patients. The number of enlarged nodes, was most prevalent between 6-10, seen in 16 patients (52%) and the largest node ranged in size from 4 to 8 mm. Among the 31 patients with mesenteric lymphadenopathy, the mean size of the largest node was statistically different between the symptomatic (6.0 mm) and asymptomatic (5.0 mm) groups (p = 0.021). The number of enlarged nodes and the patient’s age were not statistically different between the two groups. CONCLUSION : Mesenteric lymphadenopathy was seen in almost all cases of childhood epidemic aseptic meningitis, and may be related to the mesenteric lymphadenitis caused by enterovirus.

[내 도시락을 소개합니다] 끝물 채소로 만든 텃밭 도시락

문성희 메이데이 2021 Paper Vol.262 No.-

통초(Tetrapanax papyriferus) 추출물의 세포독성 및 Apoptosis 유도 활성

문성희,이정민,김현정,강용경,박해룡 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.3

In this study, we used methanolic extracts of Tetrapanax papyriferus (TPM) to determine their anticancer activities on HT-29 human colon cancer cells. After TPM treatment, morphological changes,such as chromatin condensation, were observed in HT-29 cells. We confirmed cytotoxicity through cell biological assays after treatment with TPM at various concentrations. An MTT reduction assay revealed that TPM treatment at a concentration of 500 μg/ml yielded a cell viability of 39.4%. The findings indicated that strong anticancer activity restricted colony formation at TPM concentration greater than 10 μg/ml. In addition, we performed apoptosis in a series of experiments in order to determine the cell biological mechanism of TPM cytotoxicity. By Hoechst staining, we confirmed the formation of apoptotic bodies in cells treated with TPM. The results of flow cytometric analysis indicated that while the number of cells in the sub-G1 phase was 0.7% in the control group and 13.1% in the group treated with 250μg/ml TPM, we could identify a high apoptotic effect. Based on these results, we could confirm that TPM induces apoptosis in cancer cells and has strong anticancer properties.

Mollugin enhances the osteogenic action of BMP-2 via the p38–Smad signaling pathway

문성희,김익윤,김성환 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.11

Bone morphogenetic protein 2 (BMP-2) hasbeen used clinically to encourage bone regeneration;although, there can be major side effects with larger doses. Therefore, there is a need to identify new small moleculesto potentiate the osteogenic action of BMP-2. In this study,we investigated the effect of mollugin on bone formation inmurine bi-potential mesenchymal progenitor C2C12 cellsby combination with BMP-2. We found mollugin couldenhance the BMP-2-mediated osteoblast differentiation ofC2C12 cells. This was accompanied by the induction ofother osteogenic BMPs. We also found the enhancingpotential of mollugin may involve activation of the p38–Smad1/5/8 signaling axis. Furthermore, mollugin promotedskeletal development in zebrafish. The combination ofBMP-2 with small molecules, including mollugin, couldminimize its clinical limitations, and these molecules mightlead to the development of effective stem cell stimulantsfor bone regeneration and fracture healing.