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문상원,송유미,조희윤,이병로,손준홍,박영숙 대한안과학회 2009 대한안과학회지 Vol.50 No.10
Purpose: To report on 2 cases of Eales’ disease that were successfully regressed with laser photocoagulation and intravitreal bevacizumab (Avastin; Genetech, Inc, San Francisco, California, USA) injection. Case summary: Two male patients (30 years and, 40 years of age,) with a history of recurrent vitreous hemorrhage were diagnosed with Eales’ disease. The 2 patients had peripheral retina neovascularization and active phlebitis in fundus fluorescein angiography. No other findings were observed in their eyes in the general examination. Scatter laser photocoagulation and intravitreal bevacizumab injection were performed. After 1 month follow-up, neovascularization completely regressed. There was no complication or recurrent vitreous hemorrhage at the 1 year follow up. Conclusions: Intravitreal bevacizumab injection, as combination treatment of laser photocoagulation, may be helpful in the regression of neovascularization due to Eales’ disease. 목적: 일스병에서 유리체강내 베바시주맙 주입술과 레이저광응고술을 시행하여 효과적인 관해를 얻은 2예를 보고하고자 한다. 증례요약: 갑자기 시작된 시력 저하를 주소로 내원한 30, 40세 남자 환자 2명에서 안저 검사 및 형광 안저 촬영상 활동적인 정맥염과 주변부 망막 신생혈관 및 유리체출혈이 관찰되었다. 안구 다른 부위의 이상소견은 없었으며, 전신적인 검사에서도 특이 소견은 없었다. 일스병 진단 하에 망막 레이저광응고술을 시행한 뒤 유리체강내 베바시주맙 주입술을 시행하였으며, 한 달 후 신생혈관은 퇴행되었다. 1년간의 경과 관찰 도중 일스병의 재발, 즉 반복적인 유리체출혈이나 신생혈관의 형성 등은 보이지 않았고, 합병증 역시 관찰되지 않았다. 결론: 일스병의 신생혈관에 대한 기존 치료는 레이저광응고술을 하는 것이었으나, 잦은 유리체출혈의 재발 등으로 한계가 있었다. 레 이저광응고술 중에도 진행하는 신생혈관과 재발한 신생혈관 치료에 유리체강내 베바시주맙 주입술을 하여 효과적인 신생혈관의 퇴행을 경험하였다. 저자들은 일스병에서 유리체강내 베바시주맙 주입술을 레이저 치료의 병합치료로서 보고하고자 한다.
문상원,이윤정,이영석,정진혁,Sang Won Moon,Yoon Jung Lee,Young Suk Lee,Jin Hyuk Jung 대한안과학회 2009 대한안과학회지 Vol.50 No.3
Purpose: To report a case of simultaneous orbital cellulitis and intracranial complications of acute sinusitis in a young patient. Case summary: The 11-year-old male presented with a one-day history of left periorbital erythematous swelling, fever and headache. He was diagnosed with acute sinusitis at the department of otorhinolaryngology, and endoscopic sinus drainage of pus was performed. However, the patient’s symptoms did not improve. The next day, a subdural abscess was found on brain computed tomography. He was treated by external drainage of the periosteal abscess via a subbrow incision and systemic antibiotics, as well as anticonvulsant medication. Conclusions: Twenty days after external drainage and beginning systemic antibiotics and anticonvulsant treatment, he was discharged with improved orbital cellulitis symptoms and a resolved subdural abscess
정상안 및 황반 질환에서 스펙트럼 영역 빛간섭단층촬영(3D-OCT 1000)의 황반 두께 및 부피 반복성
문상원,이정민,송유미,조희윤,이병로,Sang Won Moon,Jung Min Lee,You Mi Song,Hee Yoon Cho,Byung Ro Lee 대한안과학회 2010 대한안과학회지 Vol.51 No.4
Purpose: To evaluate the repeatability of macular thickness and total macular volume measurements made using spectral domain optical coherence tomography (OCT) in normal subjects and subjects with macular disease. Methods: Among a total of 108 subjects, there were 50 normal subjucts, 20 patients with diabetic macular edema, 10 patients with retinal vein occlusion, 15 patients with age-related macular degeneration, and 13 subjects with other conditions. Two serial macular measurements were obtained from each subject by a single experienced examiner using spectral domain OCT. The repeatability of the measurements was evaluated by comparing two consecutive foveal and perifoveal thickness measurements and total macular volume measurements. The intraclass correlation coefficient was also calculated to evaluate the repeatability of measurements made in normal and macular disease subjects. Result: Spectral domain OCT measurements of macular thickness and macular volume were found to be consistent. Measurements of normal subjects were the most consistent, followed by measurements of patients with age-related macular degeneration, retinal vein occlusion, and diabetic macular edema. Conclusions: Although measurements made using spectral domain OCT were repeatable across all subjects, they were more consistent in normal subjects than in patients with macular disease. The differences in repeatability should be considered in the context of diseased pathologic anatomy. Physicians should remain cautious when using these measurements for clinical evaluation. J Korean Ophthalmol Soc 2010;51(4):524-531