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Peptide Nucleic Acid (PNA)의 의생명과학에 응용
정동준,정유준,목문협,박소영,최영진,김창진 순천향대학교 순천향의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.15 No.2
Peptide nucleic acid (PNA) are synthetic mimics of nucleic acids in which the deoxyribose phosphate backbone is replaced by a flexible pseudo-peptide polymer to which the nuclear bases are linked. This structural properties enable PNAs to hybridize with high affinity and specificity to complementary sequences of DNA and RNA. They also confers remarkable resistance to DNAses and proteinases. Over the last few years, several exciting new applications of PNA technology has been published in the biomedicine of genetics, cytogenetics and viral diagnostics. PNA-based hybridization technology is developing rapidly in the field of in situ hybridization as well.