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일개 농촌지역 주민이병 실태에 관한 조사 : 1988년 경기도 남양주군 수동면 Su-Dong Myun, Nam Yang-Ju Gun, Kyung-Gi Do
곽정아,맹신숙,곽현주 이화여자대학교 의과대학 1990 梨花醫學誌 Vol.- No.22
In order to know about the morbidity status in a Korean rural community, Su-Dong Myun, Nam Yang Ju Gun, Kyung-Gi Do, this study was carried out through analyzing the medical records of Su-Dong Myun Health subcenter during the period of January to December, 1988 and the following results were obtained. 1) Population of Su-Dong Myun was 4,820 composed of 2,550 male and 2,270 female and the sex ratio was 112.3. 2) The number of new patients visited to Su-Dong Myun Health subcenter was 1,352 composed of 666 male and 686 female during the year of 1988. 3) Annual utilization rate in total was 280.5 per 1,000 population and 261.2 for male and 302.2 for female and the highest age specific utilization rate was 774.8 per 1,000 in the age group of 0∼4 and the lowest was 75.9 per 1,000 in the age group of 15∼19. 4) The order of five major diseases was Diseases of Respiratory system(49.3%), Diseases of the Digestive system(13.8%), Diseases of the skin and subcutaneous Tissue (12.0%), Diseases of Musculoskeletal system and Connective Tissue (11.3%), Accidents Poisoning and Violence(5.7%). 5) The average visiting time of out-patients in the Health subcenter was 3.5 per case. The range of average visiting time of diseases was 1.2∼7.0. 6) The annual inhibitant ulilization rate by Rie was highest in Ribsouk Rie (382.3), and the lowest in Song-Chon Rie(166.9) per 1,000. 7) The monthly distribution of out-patients visited to Su-Dong Myan Health subcenter was shown the highest rate in April(37.8%) and the lowest in December(9.3%). 8) Average medical tee per case was 5,200±4,100.
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장병우,맹신숙,조지연 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.3
The coexistence of intrauterine and extrauterine gestation is a somewhat rare obstetric phenomenon thought to occur in 1 of 30,000 spontaneous pregnancy. Recently, Assisted reproductive technology such as IVF and ET are increasingly common in the management of infertility. There is a higher maternal morbidity and fetal loss due to delayed or missed diagnosis, so a combined pregnancy is guite difficult to diagnosis clinically. We experienced a case of intrauterine pregnancy coexisting with right tubal pregnancy as combined pregnancy in 24 year old nulliparous woman, so we reported this case with a brief review of the literature.
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인간 자궁내막에서 IL-6 및 IL-6 수용체의 발현에 관한 연구
김성숙,안정자,전선희,정혜원,김수연,맹신숙,조지연 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.11
Endometrial cells undoergo a series of proliferative and secretory changes. These changes are precisely controlled and prepare endometrium for implantation of the blastocyst. It is thought that these changes are primarily dirven by two steroid hormones, estrogen and progesterone. However, recently it is suggested that many of the endometrial functions are controlled by various cytokines and reported presence of IL-1α, IL-1β, IRAP, IL-6, TGF-α proteins is human endometrium throughout the menstrual phase. Endometrial cells produced IL-6 in response to other inflammation-associated cytokines such as IL-1αorβ, TNF-α, IFN-γ. This secretion was strongly inhibited by 17-β estradiol. This established a novel li-nk between the endocrine and the immune systems. Therefore, this study was designed to examine the cell and site specific distribution of IL-6 and IL-6 receptor and the role of IL-6 in human endometrium during menstrual cycle. Endometrial tissues were obtained from hysterectomy specimens from normally cycling 44 patients in Ewha Womans University Hospital during past 14 months(1995. 1.1~1996. 2.29). The uteri were removed for abnormalities other than endometrial origin including uterine leiomyomas and cervical or ovarian lesions. Immunohistochemical staining was performed for IL-6 and IL-6 receptor in endometrial tissues. The results were as follows: 1. During the proliferative phase, expression of IL-6 was weak to absent in endometrial glands and stroma. 2. During the secretory phase, expression of IL-6 was stronger than that of proliferative phase and progressively increased in the mid- to late secretory phases. Expression of epithelial IL-6 was stronger than stroma. 3. IL-6 receptor was expressed primarily in endometrial glands and to a lesser extent in stroma. Expression of IL-6 receptor did not change throughout the menstrual cycle. Accordingly, this study show a cell and site specific distribution of IL-6 and IL-6 receptor in human endometrium through menstrual cycle. The menstrual cycle dependent expression of IL-6 suggest that this cytokine was controlled by steroid hormones. The menstrual cycle independent expression of IL-6 receptor suggest that IL-6 may act on endometrial function by autocrine and/or paracrine mechanisms. Increased expression of IL-6 in mid- to lat secretory phase suggest that IL-6 may be implicated in the induction of changes in human endometrium during the secretory/menstrual phase.
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안정자,김영주,정혜원,김승철,박미혜,김수연,김미정,성순희,맹신숙,조지연 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.6
저자들은 1995년 6월에 천미골기형종이 동반된 임신중독증 산모 1례를 경험하였기에 간단한 문헌고찰과 함께 보고하는 바이다. Sacrococcygeal teratoma(SCT) is rare malformation which may reach a large size and cause considerable difficulty during delivery. Recently authors diagnosed this fetal tumor using ultrasonography during antenatal period, so we present this case with a brief review of the literatures.
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