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풍선도자에 의한 흰쥐의 경동맥 손상 후 phospholipase C-γ1 발현의 변화
임성훈(Seong Hoon Lim),허영선(Young Sun Heo),김학진(Hak Jin Kim),이왕수(Wang Soo Lee),안지현(Ji Hyun Ahn),송영빈(Young Bien Song),김상욱(Sang Wook Kim),김태호(Tae Ho Kim),김치정(Chee Jeong Kim),류왕성(Wang Seong Ryu),유언호(Un Ho Ryo 대한내과학회 2001 대한내과학회지 Vol.60 No.3
Background : While inositol phospholipid-specific phospholipase C (PLC) plays a central role in signal transduction pathways, little is known about its role in the vascular response to injury. Recent studies have shown that phospholipase C-γ1 (PLC-γ1) is required for PDGF-induced DNA synthesis and angiotensin II signaling. This study was undertaken to determine the potential involvement of PLC-γ1 in the in vivo response to vascular injury. Methods : Vascular injury was achieved in the left common carotid artery of six-month-old male Wistar rats. The expression of PLC-γ1 was evaluated at serial time points by immunohistochemistry and Western blot analysis following balloon de-endothelialization of the rat carotid artery. Results : In the denuded carotid artery at 1 week, the neointima became thicker in a symmetrical manner with respect to the long axis. A strong expression of PLC-γ1 at one week after injury was seen primarily in the thin layers of neointima. This increased immunoreactivity of PLC-γ1 persisted at 2-3 weeks after injury, coinciding with the time when neointima gains of its mass. At 4 weeks after injury, staining intensity slightly declined but levels remained elevated. As determined by Western blot analysis, the amount of PLC-γ1 was about 3-fold higher at 3 weeks after injury compared to uninjured vessels (p<0.01). Conclusion : These results suggest that the amplification of traffic within signal transduction pathways involving PLC-γ1 occurs and may play a significant role in neointima formation following arterial injury.(Korean J Med 60:234-241, 2001)
당뇨병 환자에서 비관혈적 방법에 의한 좌심실기능 평가에 관한 연구
방준경(Joon Kyung Bang),현창훈(Chang Hun Hyun),이병직(Byung Jik Lee),류왕성(Wang Seong Ryu),권기익(Ki Ik Kwon),강창순(Chang Soon Kang),유언호(Un Ho Ryoo) 대한내과학회 1987 대한내과학회지 Vol.32 No.4
N/A Diabetes mellitus has been clearly identified as an independent risk factor in coronary heart diasase, sudden death, congestive heart failure, stroke, and peripheral vascular disease. The diabetic patient is twice as prone to develop heart disease as the general population. Recently the term Diabetic cardiomyopathy has been appeared in medical publications. This term imply the existence of a specific diabetic heart disease, a new nosological entity that has been growing out of several studies performed during the last few years by research workers in diabetes. The assessment of left ventricular function as an index of potential myocardial involvement in diabetic patients without clinical evidence of myocardial ischemia or other cardiovascular abnormalities has become increasingly important. To examine left ventricular function in diabetic patients without clinical evidence of cardiac involvement, eleetrocardiogram, phonocardiogram, carotid pulse tracing, echocardiogram, apexardiogram, and the first derivative of the apexcardiogram were performed in normal subjects and 16 diabetic patients. The results were as follows. 1) Corrected R to first peak interval was 96.1±25.9 msec in diabetic group and 66.3±14.8 msec in control group (p<0.05), height ratio was 52.9±7.4% in diabetic group and 56.5±4.0% in control group (p<0.05). S to second peak interval was not significant value. 2) Pre-ejection period was 85.9±27.2 msec in diabetic group and 40.9±12.2 msec in control group (p<0.05), left ventricular ejection time was 302.5±39.9 msec in diabetic group and 340.0±20.7 msec in control group (p<0.05). Electromechanical systole was not significant value. 3) A-MVO was 90.4±19.1 msec in diabetic group and 64.8±13.7msec in control group (p<0.05), ejection fraction was 59.5±11.2% in diabetic group and 68.5±7.5% in control group (p<0.05). Based on these findings, mechanocardiography for assessment of left ventricular function may be utilized as a good index of potential myocardial involvement in diabetic patients.
확장성심근중 환자에서 Enalapril 치료가 좌심실내경의 순간변화율에 미치는 영향
김철우(Cheol Woo Kim),정유석(Yoo Suk Jung),이광제(Kwang Je Lee),곽미향(Mi Hyang Kwak),김경만(Kyung Man Kim),김태호(Tae Ho Kim),김치정(Chee Jeong Kim),류왕성(Wang Seong Ryu),유언호(Un Ho Ryoo) 대한내과학회 1997 대한내과학회지 Vol.52 No.5
Objective: Angiotensin-converting enzyme inhibitors have been shown to improve survival in patients with congestive heart failure. To evaluate the efficacy of enalapril in patients with dilated cardiomyopathy during concurrent treatment with digoxin and diuretics, the peak rates of left ventricular movement were assessed after 6 months of follow-up by digitized echocardiography. Methods: Using a high quality digitizer, continuous measurement of left ventricular dimension and its rate of change (dD/dt) were obtained throughout the cardiac cycle. Normalized rates of wall movement (dD/dt/D) were used for comparison. Results: 1) Compared with control subjects, patients with dilated cardiomyopathy showed much lower Peak(-) dD/dt and Peak(-) dD/dt/D. 2) Peak(+) dD/dt and Peak(+) dD/dt/D were also depressed in patients. 3) Peak dD/dt improved significantly (p<0.05) in the enalapril group (n=16), but did not change in the conventional treatment group (n=20) after 6 months. Peak dD/dt/D improved approximately (p<0.005) in the enalapril group. 5) There were no deaths in 2 treatment groups during initial 6 months, but 3 patients in the conventional treatment group died suddenly during 1 year of follow-up. Conclusion: The present study has shown that left ventrieular Peak dD/dt and Peak dD/dt/D are significantly depressed in patients with dilated cardiomyopathy. Enalapril appears to provide well-tolerated and effective long-term therapy by improving peak rates of left ventricular movement in patients with dilated cardiomyopathy.
Doppler 심 초음파에 의한 폐 동맥 혈류 측정에 있어서 관찰 View 에 따른 비교
김태호(Tae Ho Kim),최신환(Sin Whan Choi),장용준(Yong Jun Jang),류호준(Ho Jun Ryoo),심상준(Sang Jun Shim),류왕성(Wang Seong Ryu),유언호(Un Ho Ryoo) 대한내과학회 1989 대한내과학회지 Vol.37 No.5
N/A The analysis of pulmonary blood flow by Doppler echocardiography is very useful in evaluating various cardiac patients with pulmonary hypertension. How- ever, determinations of pulmonary arterial blood flow can vary markedly when measured from different sites. One hundred subjects (90 normal subjects, 10 C.O.P.D. patients) underwent Doppler and two-dimensional echocardiographic examination of the pulmonary artery from multiple views to determine the variability in the magnitude of Doppler determined peak velocity, acceleration time of pulmonary arterial blood flow and pulmconary arterial diameter. The results were as follows: 1) The maximun diameter of the pulmonary artery was 2.0±0.5cm (mean±S.D) and was measured from the parasternal right ventricular outflow tract (PRVOT) view (78), the subcostal short axis (SCSAX) view (65) and the parasternal short axis (PSAX) view (51) in turn. 2) The peak. velocity of pulmonary blood flow was mostly detected from the PRVOT view (59%) and sometimes from the PSAX view (17%). 3) The highest flow velocity of the pulmonary artery was recorded from the SCSAX view in 24 patients including 8 C.O,P,D patients. 4) Our results indicate that the PRVOT view was most useful in evaluating the image and blood folw pattern of the pulmonary artery, and in some cases (such as C.O.P,D), the SCSAX view was much better than any other view.
고혈압 환자에서 24 시간 활동 혈압과 좌심실비대와의 상관관계에 대한 연구
김상욱(Sang Wook Kim),유재격(Jae Kyuk Rhoo),김현대(Hyun Dae Kim),이은우(Eun Woo Lee),이성윤(Sung Yun Lee),박승호(Seung Ho Park),류왕성(Wang Seong Ryu),유언호(Un Ho Ryoo) 대한내과학회 1993 대한내과학회지 Vol.45 No.1
Background: 24-hour noninvasive ambulatory blood pressure monitoring (ABPM) has been shown to be superior to casual BP in predicting target organ involvement in patients with hypertension and assessing anti-hypertensive therapy. This study was done to examine the relation of BP decline from day to night to the echocardiographic parameters of left ventricular anatomy in unselected hypertensive patients and normotensive subjects undergoing 24-hour noninvasive ABPM. Methods: The effect of variation of blood pressure on the echocardiographic parameters of left ventricular hypertrophy were investigated in 71 consecutive subjects. (47 patients with essential hypertension and 24 healthy normotensive subjects). 24-hour noninvasive ambulatory blood pressure monitoring and cross-sectional and M-mode echocardiography were done to examine the relation between ABPM and echocardiographic LVH. Results: 24-hour ambulatory blood pressure was lower than casual blood pressure, and weak relation was noted particularly in patients with mild-to-moderate hypertension. The continuous monitoring of BP throughout day shows characteristic circadian pattern. The highest BP was recorded at 10 am and lowest value was at 2 am-4 am. Ambulatory daytime blood pressure (6 am-8pm) was higher 15% than night-time blood pressure (8 pm-6 am), The correlation coefficient of daytime systolic blood pressure was r=0.42 (p<0.01), twenty-four hours systolic BP was r=0.41 (p<0.05). The daytime and 24 hours systolic BP seems to be more closely related to LVH than night-time BP, but the correlation was not high enough in our study. Conclusion: 24-hour ambulatory blood pressure monitoring is more useful than casual BP in patients with hypertension, and LVH in echocardiography is more closely related to daytime and 24 hours systolic BP than night-time BP.
이성호 ( Sung Ho Lee ),이경은 ( Kyung Eun Lee ),이광제 ( Kwang Je Lee ),김상욱 ( Sang Wook Kim ),김태호 ( Tae Ho Kim ),김치정 ( Chee Jeong Kim ),류왕성 ( Wang Seong Ryu ) 대한내과학회 2007 대한내과학회지 Vol.73 No.4
Acute myocardial infarction is a rarely reported complication of amphetamine abuse. We report here on a case of a 39-year-old man who presented with cardiac enzyme patterns, a clinical history and an ECG that were all compatible with acute ST elevation myocardial infarction. This was probably the result from self administration of intravenous amphetamine. The initial coronary angiogram (CAG) showed total occlusion of the distal right coronary artery (RCA) with a large thrombus. Because the RCA was tortuous and removal of thrombus was thought not to be easy, he was treated with thrombolytic therapy and intravenous heparin followed by oral warfarin. The follow-up CAGs at 2 weeks and 10 months later showed almost complete resolution of the coronary abnormalities. In this case, the early coronary angiography was thought to be helpful to determine the relative contribution of thrombus and spasm that were associated with amphetamine abuse.(Korean J Med 73:428-431, 2007)
임상재,류왕성,유언호 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.3
The catecholamines are key regulators of many physiologic events in human beings. These catecholamine initiate target-cell response by binding to specific recognition sites, the adrenergic receptors. Super-and subsensitivity of the myocardial receptors and their functional status during myocardial failure have important clinical and pharmacological implications. The development of radioligand binding technique using radioactively labeled hormones or drugs, either agonists or antagonists, opened the new era of receptor investagarion. 〔^3H〕 Dihydroalprenolol was used to identify the veta-adrenergic receptors of rat cardiac membranes in this study. The concentration dependence of 〔^3H〕Dihydroalprenolol binding was studied with labeled compounds of various concentrations ranging from 5x 10^-11 M to 1.5x_-8M. Specific 〔^3H〕Dihydroalprenolol binding was a saturable process and Scatchard analysis of the data showed a single class of binding sites characterized by an equilibrium dissociation constant Kd of 5.2x 10^-9M and a calculated Bmax of about 68.8 fmol/mg protein. The specific binding occurred as rapidly and reversibly as the response to the unlabeled ligand and it increased as a linear function of increasing tissue concentration. Levo epinephrine was more potent than levo norepinephrine in inhibiting 〔^3H〕Dihydroalprenolol binding. The use of 〔^3H〕Dihydroalprenolol to identify beta-adrenergic receptors will make possible the study of alterations in number and affinity of cardiac beta-receptors in many clinical states of altered sensitivity to catecholamines.