효율적인 화재안전설계를 위한 축소화재시험기기 연구

류상훈,최백열,박원희 한국화재감식학회 2014 한국화재감식학회 학회지 Vol.5 No.1

The fire accidents having recently occurred are getting more and more larger and causing lots of damage in terms of property loss and casualties increase, so there is in need of technical fire safety development like comprehensive prevention solution in order to effectively prevent. In this study, we want to present an efficient method of fire safety design through FDS (Fire Dynamics Simulator) modelling techniques without full-scale fire test. So in this time, we should be developing optimization and test process to obtain fire pyrolysis properties for fire FDS firstly. Therefore, we want to find out on this paper how to analysis to predict the fire risk to fully understanding about fire phenomenon, real scale fire test should performed, but , because of cost and reproducibility, fire simulation usage has been increasing, and fire property of construction and living material during pyrolysis procedure is required for assure accuracy of fire simulation. However, those fire properties have difficulty about measurement of necessity data for reliability improvement fire simulation or fire properties during pyrolysis. Testing equipments for each properties occur a lots of cost and time. So to develop for, not the exist testing method, but the advanced fire properties computable All-in-one type testing equipment, reducing cost and reliability should be assured.

Effects of supplemented sodium butyrate on the in vitro rumen fermentation and growth performance of Hanwoo calves

류채화,김병현,이슬,정현정,백열창 충남대학교 농업과학연구소 2021 Korean Journal of Agricultural Science Vol.48 No.4

The study aimed to investigate the effects of supplemented sodium butyrate on the in vitro rumen fermentation and growth performance of Hanwoo calves. In total, four treatments were employed according to the sodium butyrate levels: no addition (control), an addition of 0.1% (treatment 1), an addition of 0.3% (treatment 2), and an addition of 0.5% (treatment 3). After 48 hours of fermentation, the ruminal pH was found to be higher in T1 than in C. Total volatile fatty acids were significantly higher in T2 and T3 than in C. The ratio of acetate and propionate was significantly lower in T1 and T3 than in C. In this study, the optimal concentration to promote rumen fermentation was found to be 0.3%, i.e., T2, and an experiment on Hanwoo calves at a farm was conducted. However, there were no significant differences between the treatment groups in terms of the daily weight gain, feed conversion ratio, and final body weight in the feeding experiment. Also, there were no significant differences in the body length, withers height, and height at hip cross between the control and the treatment groups. The addition of 0.3% sodium butyrate was most effective at promoting in vitro rumen fermentation, but it did not significantly affect the growth performance when fed to Hanwoo calves. This indicates that the addition of sodium butyrate improved rumen fermentation but did not have a growth-promoting effect. Future studies need to compare growth and carcass performance outcomes to confirm long-term effects.

사료 내 조단백질 및 칼슘 수준에 따른 비육후기 거세한우의 성장성적 및 도체특성에 미치는 영향

류채화,이성대,이슬,백열창 한국유기농업학회 2023 韓國有機農業學會誌 Vol.31 No.4

This study was conducted to confirm the growth performance of Hanwoo steers according to the crude protein and calcium levels and their effects on carcass characteristics. The experiment consisted of a total of 4 groups: HPHC (CP 15%, Ca 1.2%), HPLC (CP 15%, Ca 0.6%), LPHC (CP 12.5%, Ca 1.2%), LPLC (CP 12.5%, Ca 0.6%). In the feeding trial, Hanwoo steers (650.8±16.27 kg, n = 32, 24 months of age) were divided into four feeding groups (n = 8 each) with the same initial body weight. Animals were fed with each rice straw and concentrate (1:9) until the late fattening stage. Growth performance was measured by daily weight gain, feed conversion rate, and final weight. Carcass characteristics were measured carcass weight, loin area, back-fat thickness and marbling score. There was no significant difference in growth performance and carcass characteristics among the treatment groups. However, the ratio of meat quality grade 1+ or higher was 76% in LPLC, which was higher than other treatments (HPHC, 63%; HPLC, 63% and LPHC, 50%). Therefore, reducing crude protein in the feed did not affect growth and carcass characteristics. In addition, calcium control in the late fattening stage did not affect growth performance. In LPLC, the ratio of meat quality 1+ or higher was the highest, so additional research on calcium control in feed is thought to be necessary. However, there was no significant difference in the relationship between protein and calcium levels in feed in all study results, so the influence of the two factors on each other is thought to be low.

유지에너지 이상의 사료공급이 거세 한우의 영양소 소화율 및 에너지가에 미치는 영향

류채화,이성대,이슬,백열창 한국유기농업학회 2023 韓國有機農業學會誌 Vol.31 No.4

Supplying an appropriate amount of feed is an economical and environmentally friendly by increasing the nutrient digestibility of livestock and reducing nutrients released from overfeeding. Therefore, this study was conducted to determine the nutrient digestibility according to dietary feeding levels of Hanwoo steers. Three treatments in feeding trial were used feeding amount based on the maintenance energy level of the Korean feeding standard for Hanwoo (2022): 100% (control, CON), 140% (treatment 1, TRT1), and 190% (treatment 2, TRT2). The experiment was designed in replicate 3×3 balanced Latin square designs using six Hanwoo steers. In this study, energy value was predicted according to treatment groups. In addition, nutrient digestibility and energy value were measured through a feeding trial to Hanwoo steers. All energy values, including total digestible nutrients and digestible energy, were predicted to decrease linearly with increasing feeding levels. TRT2 showed lower digestibility than CON for dry matter, crude protein, non-fiber carbohydrates, and total digestible nutrients in the feeding trial (p<0.05). However, there was no significant difference between CON and TRT1. Total digestible nutrients (TDN) and digestibility of feed are set based on the maintenance energy. However nutrient digestibility and TDN decreased when feeding level increased by more than 190% compared to maintenance energy in this study. Therefore, it is necessary to correct the TDN by considering the feeding level when mixing the feed.

신규 조사료원 사료용 벼 사일리지의 사료가치 평가 및 급여 비율에 따른 반추위 발효성상 비교

박설화,백열창,이슬,김병현,류채화 한국초지조사료학회 2020 한국초지조사료학회지 Vol.40 No.4

This study was to evaluate the feed value of whole crop rice silage (WCRS) and to investigate a suitable ratio of the WCRS and concentrate by an analysis of rumen fermentation. A total of 6 treatments were used according to WCRS: concentrate ratio on in vitro rumen fermentation: T1 (100:0), T2 (60:40), T3 (40:60), T4 (20:80), T5 (10:90), and T6 (0:100). The ruminal pH, total gas emission, ammonia nitrogen, and volatile fatty acid (VFA) were determined as fermentation parameters. Total nutrients digestibility trial was conducted by 4 treatments according to WCRS: concentrate ratio at 40:60 (W40), 20:80 (W20), and 10:90 (W10), respectively. Feed value was analyzed according to AOAC (2019) and nutrient digestibility was calculated based on NRC (2001). The levels of crude protein (CP), crude fat, and neutral detergent fiber of the WCRS were 12.29%, 1.67%, and 59.79%, respectively. It was found to be 51.49% as a result of predicting the total digestible nutrient of WCRS using the NRC (2001) model. In vitro rumen fermentation, T4, T5, and T6 treatments showed a greater gas emission and total VFA concentration compared with other treatments (p<0.05). Acetate and acetate to propionate ratio of T4, T5, and T6 were significantly higher than other treatments (p<0.05). There was a significant difference in the level of propionate and butyrate according to the WCRS: concentrate ratio (p<0.05). The digestibility of dry matter and CP was significantly lower in W40 than in other treatments (p<0.05); however, there was no difference in W20 and W10. In conclusion, the 20:80 (WCRS: concentrate) is beneficial for stabilizing the rumen that does not inhibit rumen fermentation and nutrient digestion. This ratio might have a positive effect on the economics of farms as a valuable feed.

Prognostic Value of Immunohistochemical Staining of p53, bcl-2, and Ki-67 in Small Cell Lung Cancer

백광현,박연희,류백열,양성현,이재철,김철현,기승석,김정민,박명준,안희준,최원,정진행 대한의학회 2006 Journal of Korean medical science Vol.21 No.1

Analysis of Plasma Circulating Tumor DNA in Borderline Resectable Pancreatic Cancer Treated with Neoadjuvant Modified FOLFIRINOX: Clinical Relevance of DNA Damage Repair Gene Alteration Detection

임동훈,윤현석,김규표,류백열,이상수,박도현,송태준,황대욱,이재훈,송기병,김송철,홍승모,형재원,유창훈 대한암학회 2023 Cancer Research and Treatment Vol.55 No.4

Purpose There are no reliable biomarkers to guide treatment for patients with borderline resectable pancreatic cancer (BRPC) in the neoadjuvant setting. We used plasma circulating tumor DNA (ctDNA) sequencing to search biomarkers for patients with BRPC receiving neoadjuvant mFOLFIRINOX in our phase 2 clinical trial (NCT02749136). Materials and Methods Among the 44 patients enrolled in the trial, patients with plasma ctDNA sequencing at baseline or post-operation were included in this analysis. Plasma cell-free DNA isolation and sequencing were performed using the Guardant 360 assay. Detection of genomic alterations, including DNA damage repair (DDR) genes, were examined for correlations with survival. Results Among the 44 patients, 28 patients had ctDNA sequencing data qualified for the analysis and were included in this study. Among the 25 patients with baseline plasma ctDNA data, 10 patients (40%) had alterations of DDR genes detected at baseline, inclu-ding ATM, BRCA1, BRCA2 and MLH1, and showed significantly better progression-free survival than those without such DDR gene alterations detected (median, 26.6 vs. 13.5 months; log-rank p=0.004). Patients with somatic KRAS mutations detected at baseline (n=6) had significantly worse overall survival (median, 8.5 months vs. not applicable; log-rank p=0.003) than those without. Among 13 patients with post-operative plasma ctDNA data, eight patients (61.5%) had detectable somatic alterations. Conclusion Detection of DDR gene mutations from plasma ctDNA at baseline was associated with better survival outcomes of pati-ents with borderline resectable pancreatic ductal adenocarcinoma treated with neoadjuvant mFOLFIRINOX and may be a prognostic biomarker.

A Case of Composite (Mixed) denocarcinoma-Small Cell Carcinoma of the Stomach

Kim, Nam Don,Park, Yeon Hee,Ki, Seung Seog,Park, Yong Jin,Kim, Heoyng Joon,Ryoo, Baek-Yeol,Kim, Heung Tae,Chung, Jin-Haeng,Yuh, Young Jin 인제대학교 백병원 2003 仁濟醫學 Vol.24 No.1

A composite (mixed) tumor is defined as a glandular-endocrine cell carcinomas characterized by an intricate admixture of both elements in the same lesion. The histogenesis of this tumor is not clear but is considered to be multidirectional differentiation from pluripotential stem cells. The clinical findings are local symptoms due to mass and systemic symptoms due to paraneoplastic syndrome. The prognosis is considered to be very poor because of a high incidence of vasculo-lymphatic invasion and markedly deep infiltration of small cell carcinoma (SCC) of this composite tumor. Treatment has not been established clearly yet, but treatment with regimens specific for SCC of the lung may be used because the biologic and clinical characteristics of gastric SCC are similar to those of SCC of the lung. We encountered a 70-year-old man with pain to the back and both elbows for 20 days on July 22, 2002. Esophagogastroduodenoscopic biopsy revealed a superficially well differentiated adenocarcinoma and a deeply located. poorly differentiated SCC in the same lesion of the stomach, along with multiple bony metastases. We treated the patient with a chemotherapeutic regimen (etoposide and carboplatin) and palliative radiotherapy. The patient complained of sustained abdominal pain and poor oral intake and he died about 5 months later.

Survival Benefit of Adjuvant Chemotherapy in Patients with Pancreatic Ductal Adenocarcinoma Who Underwent Surgery Following Neoadjuvant FOLFIRINOX

이소흔,황대욱,유창훈,김규표,강소라,정재호,오동욱,송태준,이상수,박도현,서동완,박진홍,송기병,이재훈,이우형,박예종,곽봉준,장흥문,류백열,김송철 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3

Purpose The benefit of adjuvant chemotherapy following curative-intent surgery in pancreatic ductal adenocarcinoma (PDAC) patients who had received neoadjuvant FOLFIRINOX is unclear. This study aimed to assess the survival benefit of adjuvant chemotherapy in this patient population. Materials and Methods This retrospective study included 218 patients with localized non-metastatic PDAC who received neoadjuvant FOLFIRINOX and underwent curative-intent surgery (R0 or R1) between January 2017 and December 2020. The association of adjuvant chemotherapy with disease-free survival (DFS) and overall survival (OS) was evaluated in overall patients and in the propensity score matched (PSM) cohort. Subgroup analysis was conducted according to the pathology-proven lymph node status. Results Adjuvant chemotherapy was administered to 149 patients (68.3%). In the overall cohort, the adjuvant chemotherapy group had significantly improved DFS and OS compared to the observation group (DFS: median, 13.8 months [95% confidence interval (CI), 11.0 to 19.1] vs. 8.2 months [95% CI, 6.5 to 12.0]; p < 0.001; and OS: median, 38.0 months [95% CI, 32.2 to not assessable] vs. 25.7 months [95% CI, 18.3 to not assessable]; p=0.005). In the PSM cohort of 57 matched pairs of patients, DFS and OS were better in the adjuvant chemotherapy group than in the observation group (p < 0.001 and p=0.038, respectively). In the multivariate analysis, adjuvant chemotherapy was a significant favorable prognostic factor (vs. observation; DFS: hazard ratio [HR], 0.51 [95% CI, 0.36 to 0.71; p < 0.001]; OS: HR, 0.45 [95% CI, 0.29 to 0.71; p < 0.001]). Conclusion Among PDAC patients who underwent surgery following neoadjuvant FOLFIRINOX, adjuvant chemotherapy may be associated with improved survival. Randomized studies should be conducted to validate this finding.

Real-Life Experience of Sorafenib Treatment for Hepatocellular Carcinoma in Korea: From GIDEON Data

김도영,김혜진,한광협,한상영,허정,우현영,엄순호,김열홍,권영오,임호영,윤정환,이완식,이병석,이한추,류백열,윤승규 대한암학회 2016 Cancer Research and Treatment Vol.48 No.4

Purpose The purpose of this study is to report real life experiences of sorafenib therapy for hepatocellular carcinoma (HCC) in Korea, using a subset of data from GIDEON (Global Investigation of Therapeutic Decisions in HCC and of Its Treatment with Sorafenib; a large, prospective, observational study). Materials and Methods Between January 2009 and April 2012, a total of 497 patients were enrolled from 11 sites in Korea. Of these, 482 patients were evaluable for safety analyses. Case report forms of paper or electronic version were used to record safety and efficacy data from all patients. Results More patients of Child-Pugh A received sorafenib for > 8 weeks than did patients of Child- Pugh B (55.5% vs. 34.3%). Child-Pugh score did not appear to influence the starting dose of sorafenib, and approximately 70% of patients both in Child-Pugh A and B groups received the recommended initial daily dose of 800 mg (69.0% and 69.5%, respectively). The median overall survival (OS) and time to progression (TTP) were 8.5 months and 2.5 months. In Child-Pugh A patients, the median OS and TTP were 10.2 months and 2.5 months. The most frequent treatment-emergent drug-related adverse event was hand-foot skin reaction (31.7%), followed by diarrhea (18.0%). The incidence of treatment-emergent adverse events was similar in both Child-Pugh A (85.4%) and Child-Pugh B (84.8%) patients. Conclusion Sorafenib was well tolerated by Korean HCC patients in clinical settings, and the safety profile did not appear to differ by Child-Pugh status. Survival benefit in Korean patients was in line with that of a previous pivotal phase III trial (SHARP).