http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Novel Kanamycin-PEI as a New Class Dendrimer for Gene Delivery
래티튀,최준식 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Recently, non-viral vectors increased the attention because of their advantages. In this study, the kanamycin-methyl acrylate-low molecular weight of polyethylenimine (KMP) library was prepared as gene carriers. Kanamycin can be hydrolysed under acidic environment. Hence, KMP 0.6 kDa, KMP 1.2 kDa and KMP 2 kDa were synthesized to determine the best gene carriers with minimize toxicity. KMPs were confirmed 1H NMR, FT-IR and buffering capacity after synthesized. Gel electrophoresis and picogreen assay have been studied to evaluate the ability to bind on DNA. The polyplexes have nanosize and positive charge. The cytotoxicity and transfection have been evaluated using human cervical carcinoma (HeLa) and human liver carcinoma (HepG2) cell line. The data implied that KMPs have lower toxic compare to PEI 25 kDa, and higher transfection compare to original low molecular weight of PEI. KMP 2 kDa and KMP 1.2 kDa are good carriers.