팔당호 유기물의 장기변동 추세 분석

노혜란 ( Hye Ran Noh ),김성미 ( Sung Mi Kim ),이명성 ( Myung Sung Lee ),박수영 ( Su Young Park ),김성수 ( Sung Soo Kim ),공동수 ( Dond Soo Kong ) 한국물환경학회 2010 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2010 No.-

수질관리 : 한강수계 BOD, COD 및 TOC 상관성 연구

노혜란 ( Hye Ran Noh ),김성미 ( Sung Mi Kim ),이명성 ( Myung Sung Lee ),손주연 ( Ju Yeon Son ),박지형 ( Ji Hyoung Park ),이형진 ( Hyung Jin Lee ),공동수 ( Dong Soo Kong ) 한국물환경학회 ( 구 한국수질보전학회 ) 2009 공동 추계학술발표회 Vol.2009 No.-

사고대비물질 현장 탐지,분석에 관한 연구

노혜란 ( Hye Ran Noh ),이진선 ( Jin Seon Lee ),김정민 ( Jung Min Kim ),김기준 ( Ki Joon Kim ),석광설 ( Kwang Seol Seok ) 한국환경분석학회 2012 환경분석과 독성보건 Vol.15 No.1

Sixty nine chemicals that have high probability of chemical accidents are designated as the substances requiring preparedness for accidents and managed for public health protection under the Toxic Chemicals Control Act. When a chemical accident or chemical terror is occurred, the exact detection and analysis of the chemicals is rapidly required for acquiring the qualitative information. In this study, the substances requiring preparation for accidents were detected and analyzed to establish stage of detection and analytical method using portable GC/MS (Gas Chromatograph-Mass Spectrometer), portable FT-IR (Fourier Transform Infrared spectrometer) and portable XRD (X-Ray Diffractometer). Volatile organic chemicals and organic gases were analyzed by GC/MS and solids having crystal structure were analyzed by XRD. Organic, inorganic liquids and solids were analyzed by portable FT-IR. Therefore, twenty four chemicals were be analyzed by portable GC/MS and forty eight chemicals were be analyzed by portable FT-IR. Also eleven chemicals were be analyzed by portable XRD. Sixty nine chemicals were classified according to their physicochemical properties. As a result, an on-site library containing the spectra generated by the above mentioned portable analysis equipments was constructed for early detection and characterization of chemical agents.

콘택트렌즈용 하이드로젤 계면에너지에 따른 단백질 흡착현상의 이해

노혜란(Hye Ran Noh),전소하(So Ha Jeon) 한국고분자학회 2012 폴리머 Vol.36 No.3

콘텍트렌즈용 하이드로젤의 계면 특성의 이해를 위해 단백질 흡착 현상을 열역학을 바탕으로 연구하였다. 다른 습윤성을 갖는 1×1 mm2 크기의 하이드로젤을 알부민(bovine serum albumin, BSA)용액에 1시간 동안 침 지시킨 후 남아있는 BSA 용액의 농도를 Bradford assay로 정량하였다. 모든 하이드로젤로의 단백질 흡착량은 단 백질 농도가 증가함에 따라 계면 흡착량이 증가하며 Langmuir 곡선의 형태를 보였다. 또한 계면과 용액내의 단 백질 농도비(P), 계산된 흡착 Gibbs free energy는 하이드로젤 재료의 친수성도가 증가함에 따라 증가하였다. 표 면에너지와 단백질 흡착량 상관관계를 이해하여 콘택트렌즈 재질로의 단백질 흡착현상의 물리화학적 해석이 가 능함을 알 수 있었다. Interfacial properties of commercially available soft contact lens hydrogels were studied to understand thermodynamic phenomena of protein adsorption. Hydrogel particles (1×1 mm2) with varying water wettability were exposed to bovine serum albumin solutions for an hour. The remained albumin solutions were analyzed with Bradford assay method. The amount of protein adsorbed to hydrogels increased with protein solution concentrations following Langmuir isotherm. The partition coefficient (P) and Gibbs free energy cost of dehydrating the surface region by protein displacement upon adsorption increased with increasing hydrophilicity of contact lens. Understanding of physical chemistry in protein adsorption to contact lens materials enabled elucidating relationships between surface energy and albumin adsorption capacity.

소프트 콘텍트 렌즈용 하이드로젤의 계면학적 및 유변학적 특성 연구

노혜란(Hye Ran Noh) 한국고분자학회 2012 폴리머 Vol.36 No.2

소프트 콘텍트 렌즈의 재질 별 계면학적 특성 및 유변학적 변화를 조사하여 렌즈 재료의 성분 설계에 기본 정 보를 제시하고자 하였다. 눈물 단백질인 albumin과 IgG의 흡착량을 측정한 결과 하이드로젤의 표면 에너지가 증가 함에 따라 점차 단백질 흡착량이 감소하는 것을 볼 수 있었다. Polydimethylsiloxane-polyvinylpyrrolidone(PDMS-PVP) 하이드로젤은 albumin과 IgG 흡착량이 가장 높았으며 poly(2-hydroxyethyl methacrylate)-polyvinylpyroolidone(HEMAPVP) 의 경우 albumin의 흡착량은 매우 미미한 것으로 나타났다. 일정한 수직항력 하에서의 하이드로젤의 토크는 실 리콘 재질인 PDMS-PVP의 경우 HEMA계열보다 약 5배 이상 크게 측정된 것을 볼 수 있었다. 흥미로운 것은 단백질 흡착량이 적은 HEMA계열 하이드로젤의 경우 실리콘 계열 하이드로젤보다 인공 눈물 내 거동 시 마찰계수가 오히 려 더 큰 것을 알 수 있었다. 인공눈물 내의 하이드로젤의 거동은 단백질 흡착으로 인한 윤활 효과 외에도 하이드로 젤 고유의 구조와 회전하는 계면의 성질에 큰 영향을 받는 것을 알 수 있었다. Interfacial and rheological properties of selected hydrogel formulations were studied to understand the contact-lens comfort in end use. It was concluded that protein adsorption from aqueous solution decreased monotonically with increasing surface energy (water wettability) of tested hydrogels. Also, it has revealed that friction coefficient of polydimethylsiloxane-polyvinylpyrrolidone (PDMS-PVP) was significantly larger that 2-hydroxyethyl methacrylate (HEMA) based hydrogels. Interestingly, in artificial tear solution, friction coefficients of HEMA based hydrogels were larger than silicone hydrogels.

강우 및 유입 하천수가 팔당호 수질에 미치는 영향분석

김종민 ( Jong Min Kim ),노혜란 ( Hye Ran Noh ),허성남 ( Seong Nam Heo ),양희정 ( Hee Jeong Yang ),박준대 ( Jun Dae Park ) 한국물환경학회 2005 한국물환경학회지 Vol.21 No.3

This paper aimed to compare the daily water quality as well as the hydrological data gathered for the past two years (2000 to 2001) between the two influent rivers of Paldang reservoir. The analysis also has been carried out to draw out the factors that affect the water quality at the dam site, where the main drinking water drawing point is located. The relationship between total amount of monthly rainfall and monthly inflow showed r²=0.74 (p<0.05). The highest peak of inflow of influent rivers recorded in August and September (in the year of 2000) and July and August (2001). Average inflows of influent rivers in 2000 and 2001 are calculated at 209.0, 161.5 CMS (Bughangang), 268.6, 148.2 CMS(Namhangang), and 7.8, 5.0 CMS (Gyeongancheon). The formula which was driven from the relationship between inflow and COD load of influent rivers, explained that COD concentration in general increased with the inflow. But during the rainy seasons (July, August, and September), COD concentration decreased according to the increase of inflow. The daily rainfall and COD concentration(or load) during the rainy season (August and September in the year of 2000, July and August in 2001) indicated that the peak of COD load correspond with the rainfall, which decreased sharply after 3 or 4 days. The reason was thought that the high COD load was diluted rapidly by the rain flow. Water temperature, pH and conductivity measured at dam site decreased obviously when the inflow sharply increased. Peak period of total phosphorus concentration coincided with that of inflow. In rainy season, chlorophyll-a concentration decreased obviously as the inflow increased. The reason can be ascribed to the flushing effect caused by the operation of floodgate.

구두발표 : 상수원 수질관리(3) ; 팔당호에서 인의 거동에 관한 연구

김은미 ( Eun Mi Kim ),노혜란 ( Hye Ran Noh ),신창민 ( Chang Min Shin ),김무영 ( Moo Young Kim ),박경화 ( Kyung Hwa Park ),정인영 ( In Young Chung ),류영조 ( Young Jo Ryu ),박혜경 ( Hae Kyung Park ) 대한상하수도학회 2005 공동춘계 학술발표회 논문집 Vol.2005 No.-

공중합체에 따른 약물 콘택트렌즈의 약물 전달 연구

김근희(Guen hei Kim),노혜란(Hye ran Noh) 인문사회과학기술융합학회 2018 예술인문사회융합멀티미디어논문지 Vol.8 No.10

본 연구에서는 hydroxyethyl methacrylate (HEMA)에 poly(vinyl pyrrolidone) (PVP), poly(N-isopropylacrylamide) (PNIPAAm), 3-(trimethoxysilyl)propyl methacrylate (TRIM)을 공중합하여, pH 변화가 하이드로젤 렌즈에서의 약물 전달 패턴을 분석하였다. 콘택트렌즈는 HEMA와 PVP, PNIPAAm, TRIM의 비율을 달리하여 열 중합하였다. 약물은 인공눈물 점안제제인 hydroxypropyl methylcellulose (HPMC)를 사용하였다. 약물방출량은 UV-spectrophotometer를 이용하여 정량 분석하였다. 그 결과, 음이온성 하이드로젤(p-HEMA, p-HEMA-VP) 렌즈는 용액의 pH가 증가 시 약물의 누적량이 점차 증가하였고, 양이온성 하이드로젤(p-HEMA-NIPAAm) 렌즈에서의 약물 누적량은 감소하였다. 또한 실리콘 함유 렌즈는 실리콘 작용기(-TRIM)의 중합에 따라 실리콘 비함유 렌즈와 반대의 약물 방출 패턴이 나타났다. 이러한 하이드로젤의 이온성 작용반응을 이용하여 눈물의 pH에 선택적으로 약물 전달량을 조절할 수 있는 콘택트렌즈 설계가 가능할 것으로 판단된다 In this study, poly (vinyl pyrrolidone) (PVP), poly (N-isopropylacrylamide) (PNIPAAm) and 3-(trimethoxysilyl) propyl methacrylate (TRIM) were copolymerized with hydroxyethyl methacrylate (HEMA). The effect of pH change on the drug delivery from the polymerized hydrogel lenses was analyzed. Contact lenses were thermally polymerized by varying the ratio of HEMA to PVP, PNIPAAm, and TRIM. Hydroxypropyl methylcellulose (HPMC), a source of artificial tear eye drops was used as a test drug. Drug releasing pattern was analyzed using a UV-spectrophotometer. As a result, the accumulated amount of the drug was gradually increased when the pH was increased in the anionic hydrogel (p-HEMA, p-HEMA-VP) lens. The released drug amount from cationic hydrogel (p-HEMA-NIPAAm) lens was decreased in increased pH. On the other hand, the silicone lens exhibited a drug release pattern opposite to that of the hydrogel lens due to the polymerization of the silicone functional group (-TRIM). This suggests that selective drug delivery from contact lens design is possible through solution-material ionization elationship depending on the polymerization components.

신규간호사의 이직의도에 미치는 영향요인

이정화(Lee, Jeong Hwa),노혜란(Noh, Hye Ran),박주영(Park, Ju Young) 대한근관절건강학회 2020 근관절건강학회지 Vol.27 No.1

Purpose: This study aimed to identify the effects of preceptor’s leadership, preceptor-preceptee exchange relationship, and preceptee’s self-leadership on newly hired nurses’ turnover intention. Methods: Participants were 175 nurses working at general hospitals in D city. Data were collected from 164 nurses in May 2019 and were analyzed using multiple linear regression with SPSS/WIN 24.0 program. Results: Newly hired nurses’ turnover intention was negatively correlated with preceptor’s transactional leadership (r=-.23, p=.003), preceptor’s emotional leadership (r=-.28, p<.001), preceptor-preceptee exchange relationship (r=-.34, p<.001), and preceptee’s self-leadership (r=-.23, p=.004). The work unit (β=.35, p<.001), preceptor-preceptee exchange relationship (β=-.28, p=.002), present work experience (β=.27, p=.043), and marital status (β=-.19, p=.009) were significant predictors of the turnover intention (R²=.26, p<.001). Conclusion: Therefore, in order to reduce the degree of turnover of new nurses, improving the exchange relationship of preceptor-preceptee is required, and balancing between work and life should be considered especially for the married new nurses.

화공안전분야 : 사고대비물질 취급자의 비상대응계획 작성 프로그램 연구

김성범 ( Sung Bum Kim ),노혜란 ( Hye Ran Noh ),석광설 ( Gwang Seol Seok ),박재득 ( Jae Deuk Park ) 한국안전학회(구 한국산업안전학회) 2011 한국안전학회지 Vol.26 No.5

Emergency preparedness plan(EPP) is the systematic management of activities that involve a material degree of risk of loss or other damage to the surroundings(people, property and environment), and the boundary of accident recovery plan(ARP). The main purpose of the program is to provide a safety management system to each facility in order to enable to prevent accident and to control accident immediately. The EPP includes not only typical safety-related documentations such as material safety data sheet(MSDS), standard operation procedure(SOP), emergency response plan(ERP). EPP is established basis of the preliminary safety analysis involving risk identification, assessment and prevention plans. The program is also helpful for government or related agencies to control a number of accidents in small-scale companies in the whole country.