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소아와 성인의 난치성 간질 환자에서 미주신경 자극술의 효과
김천식 ( Cheon Sik Kim ),노영주 ( Yeong Joo Ro ),최상용 ( Sang Yong Choi ),김대식 ( Dae Sik Kim ) 대한임상검사과학회 2006 대한임상검사과학회지(KJCLS) Vol.38 No.2
Vagal nerve stimulation (VNS) has been proposed as a possible way to improve the control of refractory epilepsy. We report the effects following VNS treatment in patients with refractory epilepsy. Seventeen patients with a mean age of 12.8 years, ranging from 5 to 29 years, underwent the implantation of vagal nerve stimulation (Cyberonics, Houston, TX). We reviewed the clinical findings before and after VNS in seizure frequency, number of antiepileptic drugs (AED), and quality of life (QOL). All of the patients had intractable seizures, eleven of the patients had additional medical complications, three had hippocampus atrophy, one had encephalomalacia, five had encephalitis, one had pachygyria, and one had schizencephaly. Thirteen patients had symptomatic partial epilepsies, three patients had Lennox-Gastaut syndrome and one had cryptogenic partial epilepsy. The mean follow up duration was 35 months. The mean reduction of seizure frequency compared with baseline before VNS was 26.1% after 3 months (p<0.005), 41.9% after 6 months (p<0.001), 46.9% after 1 year (p<0.001), and 53% at the latest follow-up (p<0.001). Twelve patients showed an improvement of QOL such as mood, language, alertness, expression, and motor function. The most common side effects were transient hoarseness or voice change or cough, which was detected in six patients (35%) and wound infection in one patient (5%). This study has shown a good anti-seizure effect of VNS, decrease in seizure frequency and improvements in QOL. We concluded that VNS is a beneficial therapy in refractory epilepsy with a non-resectable epileptic focus. Further studies should be focused on the prediction of unresponsiveness and the adjustment of VNS parameters for maximum efficacy in patients with various medical histories.
Cordyceps militaris 성분이 당대사 관련 효소 활성에 미치는 영향
김현숙(Hyun Sook Kim),노영주(Young Joo Ro),최면(Myeon Choe) 한국식품영양과학회 2005 한국식품영양과학회지 Vol.34 No.10
C. militaris 동충하초의 기능성을 규명하기 위하여 당대사 관련 효소인 GK, PDH 및 ACC 활성을 측정하였다. C.militaris에서 추출된 CM-A와 CM-B는 GK와 PDH 및 ACC 효소에 대하여 대조군에 비해 높은 활성을 나타냈으며, CM-B보다는 CM-A에서 유의적으로 높은 활성 증가를 나타냈다(p<0.05). 간세포내 당질 관련 효소의 활성은 CM-A와 CM-B 분획물의 혼합 비율에 영향을 받는 것으로 나타났는데 활성이 높은 CM-A의 비율이 커질수록 유의적으로 높은 활성 증가를 나타냈다. GK와 ACC는 단일 상태의 CM-A 보다는 혼합된 상태일 때 활성이 증가하였지만, PDH는 혼합된 상태보다는 CM-A 단독일 때 가장 높은 활성을 나타냈다. 결론적으로 C. militaris는 GK, PDH 및 ACC 등의 효소활성을 증가시킴으로써 혈중 포도당의 상승을 억제하며 이로 인해 항당뇨 작용을 한다고 판단된다. The present study was designed to investigate the antidiabetic effect of Cordyceps militaris on activities of hepatic glucose-regulating enzymes, such as glucokinase (GK), pyruvate dehydrogenase (PDH) and acetyl-CoA carboxylase (ACC). We have isolated the active compounds, CM-A and CM-B from C. militaris and the extracts are under investigation to determine their mechanism of action. Hepatic GK, PDH and ACC activities were significantly (p<0.05) increased compared with the control. Treatment with CM-A led to a rise in percentage of enzymes by 380%, 396% and 286%, respectively, relative to control levels. CM-B were 329%, 312% and 239%, respectively. The increase in GK and ACC activities was linearly proportional with increased ratio of CM-A. Our findings suggest that C. militaris exerted antihyperglycemic potency, which is thought to be mediated through activation of GK, PDH and ACC enzymes related to glucose metabolism directly or indirectly and therefore C. militaris is promising as antidiabetic functional foods.