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위암종환자의 혈청 Sialosy1-Tn 항원 발현에 대한 연구
노명환(Myung Hwan Roh) 대한내과학회 1999 대한내과학회지 Vol.56 No.6
N/A Objective: Sialosyl-Tn (sTn), a mucin-associated carbohydrate antigen, is not expressed by normal mucin- producing cells of the stomach but is expressed in metaplastic, premalignant and malignant gastric tissues. In general, the rate of immunohistochemical expression of sTn in gastric cancer tissue is about 50∼70%, and its prognostic role in gastric cancer is variable. And there is no report in Korea about serum sTn expression of gastric cancer patients , so we have examined the expression of sTn with the serum of gatric cancer patients and examined the possibility of tumor marker and of factors for prognosis. Methods: Serum sTn expression was examined by enzyme linked immuno-sorbent assay (ELISA) in 46 patients with advanced gastric cancer, confirmed at the Dong-A University Hospital, between June, 1997 and June, 1998. We examined the correlations between the expression of serum sTn antigen and patients age, sex, tumor location and size, degree of differentiation, stage, serosal invasion, peritoneal dissemination, hepatic metastasis, lymph node metastasis and Borrmann type. Results: The overall serum sTn expression was higher in cases of advanced gastric cancer than controls (p<0.05). Advanced stages had higher serum sTn expression than lower stages (p=0.0001). And in cases of serosal invasion, peritoneal dissemination and hepatic metastasis, the serum sTn expression was higher than not (p<0.05). Lymph node metastasis, one of determinant factors of stage, had high serum sTn expression but it had not statistical significance (p=0.067), and in cases of sex, tumor location and size, histologic grade and gross findings of tumor (Borrmann type) had not high expression of serum sTn (p>0.05). Conclusion: Higher expression of serum sTn in advanced gastric cancer can be proposed the possibility of the role as a tumor marker. And its higher expressions in many fields of independent prognostic factors also can be proposed the possibility of another independent prognostic factor.
정도현,노명환,이준형,김경흠,정재필,Jung, Do-hyun,Roh, Myung-hwan,Lee, Jun-hyeong,Kim, Kyung-heum,Jung, Jae Pil 한국마이크로전자및패키징학회 2017 마이크로전자 및 패키징학회지 Vol.24 No.1
Recently, research and application for a power module have been actively studied according to the increasing demand for the production of vehicles, smartphones and semiconductor devices. The power modules based on the transient liquid phase (TLP) technology for bonding of power semiconductor devices have been introduced in this paper. The TLP bonding has been widely used in semiconductor packaging industry due to inhibiting conventional Pb-base solder by the regulation of end of life vehicle (ELV) and restriction of hazardous substances (RoHS). In TLP bonding, the melting temperature of a joint layer becomes higher than bonding temperature and it is cost-effective technology than conventional Ag sintering process. In this paper, a variety of TLP bonding technologies and their characteristics for bonding of power module have been described.
이창민 ( Chang Min Lee ),노명환 ( Myung Hwan Roh ),정창길 ( Chang Kil Jung ),원종진 ( Jong Jin Won ),백양현 ( Yang Hyun Baek ),이성욱 ( Sung Wook Lee ),최석렬 ( Seok Ryeol Choi ),조진한 ( Jin Han Cho ) 대한소화기학회 2009 대한소화기학회지 Vol.53 No.6
Autoimmune pancreatitis is a distinct disease characterized by the presence of autoantibodies and hyper-gammaglobulinemia, inflammation of the pancreatic parenchyma, and irregular stricture of the pancreatic duct. The involvement of distal common bile duct is frequently observed, but intrahepatic bile duct involvement is very rare, which seem to have similar feature to primary sclerosing cholangitis. We report a case of the patient with autoimmune pancreatitis combined with extensive involvement of extrahepatic and intrahepatic bile duct, which had a favorable response to steroid therapy. (Korean J Gastroenterol 2009;53:383-387)
한지은 ( Ji Eun Han ),노명환 ( Myung Hwan Noh ),남원욱 ( Won Wook Nam ),노미숙 ( Mee Sook Roh ),박병호 ( Byung Ho Park ) 대한췌담도학회 2018 대한췌담도학회지 Vol.23 No.2
췌장의 동정맥 기형은 주로 췌장의 두부에 생기는 매우 드문질환으로 주 증상은 위장관 출혈이며, 치료는 일반적으로 침범된 기관 또는 부위의 완전 절제이다. 저자들은 급작스런 복통으로 내원하여 췌장미부에 동정맥 기형이 진단된 64세 남자 환자의 임상소견과 수술적 치료경과를 보고하고자 한다. 췌장 컴퓨터단층촬영과 자기공명담췌관 조영술 상에서 췌장미부에 다발성의 혈관생성을 동반한 동정맥 기형에 합당한 소견이 관찰되었으며 인접한 근위부 췌장에 낭성병변 동반소견이 보였다. 같은 시기에 시행한 상장간막동맥 혈관조영술에서도 췌장미부에서 동맥영상 조기에 간문맥이 관찰되는 동정맥 기형 소견이 보였다. 치료는 복강경하 원위부 췌장 절제 및 비장 절제술을 시행하였으며, 조직검사에서 췌장 미부에 동정맥 기형에 합당한 소견과 근위부에 가성낭종의 소견이 보였다. 환자는 수술 후 1주만에 합병증 없이 퇴원하였다. Pancreatic arteriovenous malformation (PAVM) is very rare anomaly. It occurs most commonly in the pancreatic head portion and gastrointestinal bleeding is the most common symptom. The management of PAVM is rather complex, with complete treatment usually accomplished by a total extirpation of the affected organ or at least its involved portion. We report the clinical presentation and management of 64 year-old male patient with PAVM, which was developed in pancreatic tail portion with sudden abdominal pain. Pancreatic computed tomography and magnetic resonance cholangio-pancreatography were consistent with a vascular formation on pancreatic tail portion and simultaneously revealed with pseudocysts beside it. A subsequent superior mesenteric artery angiographic findings depicted PAVM on pancreatic tail portion. The patient underwent laparoscopic distal pancreatectomy and splenectomy and had a favorable outcome.
위상피이형성과 위암종에서 FasL의 발현 및 Apoptosis에 관한 연구
박건욱,한상영,이종훈,금동주,노명환,최석렬,김종성,노미숙,Park Gun Uk,Han Sang Young,Lee Jong Hun,Keum Dong Joo,Roh Myung Hwan,Choi Seok Ryeol,Kim Jong Seong,Roh Mee Sook 대한위암학회 2001 대한위암학회지 Vol.1 No.2
Purpose: This study was to observe whether the apoptotic function of tumor-infiltrating lymphocytes (TIL) is induced in human gastric epithelial dysplasia and gastric adenocarcinoma according to the role of FasL expression. Materials and Methods: A total of 56 gastric epithelial dysplasia and gastric adenocarcinoma patients were enrolled in this study: 9 cases of gastric epithelial dysplasia, 18 cases of early gastric carcinomas (EGC) and 29 cases of advanced gastric carcinomas (AGC). Immunohistochemical staining was performed for FasL and CD45, and the terminal deoxynucleotidyl transferase mediated dUTP nick end labelling (TUNEL) method was used to detect cell death in tumor-infiltrating lymphocytes. Results: 1) Positive reactions of FasL to neoplastic cells were $88.9\%$ (8/9) in gastric epithelial dysplasia, $83.3\%$ (15/18) in EGC, and $75.9\%$ (22/29) in AGC. 2) Expression of TIL was decreased in the FasL positive region and was increased in the FasL negative region, and significant expression of TIL was observed in the AGC group (P=0.001). 3) Expression of apoptotic TIL was very similar to the FasL expression, and $100\%$ expression was observed in gastric epithelial dysplasia group. 4) Expression of apoptotic TIL was increased in the FasL positive region and decreased in the FasL negative region, and significant apoptotic expression was observed in the gastric epithelial dysplasia and EGC groups (P=0.0420, P=0.0263, respectively). Conclusion: These results suggest that FasL is a prevalent mediator of immune privilege in epithelial dysplasia and cancer of the stomach.
반복적인 하부위장관 출혈을 동반한 공장 평활근종 1 예
한상영(Sang Young Han),노명환(Myung Hwan Roh),최석렬(Seok Ryeol Choi),신우원(Woo Won Shin),강기태(Ki Tae Kang),김광진(Kwang Jin Kim),지삼룡(Sam Ryong Jee),이종훈(Jong Hun Lee) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.2
Small bowel tumors are rare, constituting 1.7-6.5% of all gastrointestinal tract neoplasms. Leiomyomas are uncommon benign tumors of smooth muscle and may occur wherever smooth muscle is present. The small bowel is the most frequent site and leiomyomas make up 20-30% of all benign small intestinal neoplasms. Bleeding is the most commom symptom and is usually recurrent. A 33-year-old man who came to emergency room complained of 3-day history of melena and hematochezia. An arteriogram revealed significant hemorrhage from jejunal branch of the superior mesenteric artery. Arterial embolization was performed, followed by laparoscopy-assisted small bowel resection after 17 days. Pathologic examinaton confirmed a diagnosis of leiomyoma. (Korean J Gastroenterol 2001;38:128-131)