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대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 최소증상 간성 뇌증 환자에서 신경인지검사의 유용성 연구
남순우 ( Nam Sun U ),양동원 ( Yang Dong Won ),김지훈 ( Kim Ji Hun ),김창환 ( Kim Chang Hwan ),김진일 ( Kim Jin Il ),박수헌 ( Park Su Heon ),한준열 ( Han Jun Yeol ),김재광 ( Kim Jae Gwang ),정규원 ( Jeong Gyu Won ),선희식 ( Seon Hu 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
과량의 구리를 지속적으로 투여한 쥐에서 시간적 변화에 따른 간 손상의 전자현미경적 소견
한남익 ( Nam Ik Han ),최상덕 ( Sang Duk Choi ),정규원 ( Kyu Won Chung ),남순우 ( Soon Woo Nam ),한준열 ( Joon Yeol Han ),최상욱 ( Sang Wook Choi ),이영석 ( Young Sok Lee ),선희식 ( Hee Sik Sun ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.5
Background/Aims: This study was designed to clarify the sequential morphologic changes of copper overloaded-rat liver. Methods: The Sprague-Dawley rats were divided into three groups according to copper and penicillamine administration: Group I. normal control injected with lipiodol; Group II, treated with copper only; Group III, treated with copper plus D-penicillamine. Liver tissues were stained with hematoxylin-eosin and rubeanic acid. In order to elucidate the ultrastructural changes of the liver, transmission electron microscopic examination was also performed. Results: Electron microscopic findings in copper-treated group were characterized by a number of copper-containing lysosomes at pericanalicular ectoplasm, normal sized and bizarre mitochondria with small vacuoles (at 2 weeks), dilated bile canaliculi with decreased microvilli (at 3 weeks), disruption of sinusoidal border (at 4 weeks), microsteatosis (at 5 weeks), a Councilman body-like inclusion in sinusoid and round hepatocytes undergone coagulation necrosis in sinusoid (at 7 weeks), increased collagen bundles in Disse space and loss of microvilli (at 12 weeks). There were increased copper containing granules in hepatocytes of copper plus D-penicillamine treated group, but normal ultrastructural findings were observed. Conclusions: These findings indicate that hepatic injury induced by copper overload is caused by deranged copper metabolism in the lysosome of the hepatocytes and administration of D-penicillamine in copper stressed rats seems to be effective for the restoration of hepatocyte function and morphologic changes. (Korean J Gastroenterol 2003;41:374-381)
대한간학회지 제8차 춘계학술대회 초록집 : 포스터 발표 ; 만성 간질환 환자에서 간섬유화의 정도와 혈청 히아루론산치를 이용한 간섬유화의 예측
조병식 ( Jo Byeong Sig ),남순우 ( Nam Sun U ),장정원 ( Jang Jeong Won ),배시현 ( Bae Si Hyeon ),최종영 ( Choe Jong Yeong ),윤승규 ( Yun Seung Gyu ),안병민 ( An Byeong Min ),최상욱 ( Choe Sang Ug ),이창돈 ( Lee Chang Don ),정규원 ( 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
포스터 전시 : 간 ; 우심부전과 유전성 구형적혈구증으로 발생한 심한 간비종대 1예
서석민 ( Seo Seog Min ),김창욱 ( Kim Chang Ug ),박찬권 ( Park Chan Gwon ),남순우 ( Nam Sun U ),장우임 ( Jang U Im ),최종영 ( Choe Jong Yeong ),윤승규 ( Yun Seung Gyu ),최상욱 ( Choe Sang Ug ),정규원 ( Jeong Gyu Won ),선희식 ( Seon 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<증례> 54세 여자가 내원 12시간 전부터 발생한 발열과 오한, 우상복부 동통을 주소로 응급실로 내원하였다. 과거력상 어려서부터 비장종대가 있었으나 특별한 검사 없이 지내다가 내원 2년전 호흡곤란으로 심장비대와 담석이 있다는 사실을 알고 약물치료 중 이었다. 내원당시 혈압은 120/80㎜Hg, 맥박은 분당 100회, 호흡은 분당 24회, 체온은 38.0℃였고, 창백하면서 황달이 있었다. 심음은 규칙적이었으나 강도 4정도의 수축기 잡음이 심첨과 흉골좌측
김소양 ( Kim So Yang ),김지훈 ( Kim Ji Hun ),김창환 ( Kim Chang Hwan ),남순우 ( Nam Sun U ),김윤정 ( Kim Yun Jeong ),김진일 ( Kim Jin Il ),박수헌 ( Park Su Heon ),한준열 ( Han Jun Yeol ),김재광 ( Kim Jae Gwang ),정규원 ( Jeong Gyu 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2
Pheochromocytoma, a catecholamine-producing tumor of the chromaffin tissue, may present with various features. Herein, we report case of 66-year-old woman with pheochromocytoma accompanying hyperamylasemia and acute abdomen. She was admitted to another hospital due to myocardial infarction 5 months ago. At that time, pheochromocytoma was suggested on the basis of hormonal studies, but she refused surgical resection. When she came to our hospital, serum amylase level was 703 U/L. Subsequent studies revealed pancreatic type isoenzyme, and elevated lipase level. After normalization of serum amylase level, she undertook laparoscopic adrenalectomy. On pathologic examination, pheochromocytoma was confirmed. There are several cases of pheochromocytoma with hyperamylasemia. In general, the source of hyperamylasemia was thought to be pulmonary endothelial cells under ischemic damage caused by potent vasoconstrictive action of circulating catecholamines. In our case, analysis of isoenzymes and serum lipase level suggest that hyperamylasemia can originate from the pancreas. Thus, pancreatitis also should be considered when serum amylase level is elevated in pheochromocytoma. (Korean J Gastroenterol 2003;42:172-175)
한준열 ( Han Jun Yeol ),정지성 ( Jeong Ji Seong ),조돈현 ( Jo Don Hyeon ),손동균 ( Son Dong Gyun ),남순우 ( Nam Sun U ),최종영 ( Choe Jong Yeong ),조세현 ( Jo Se Hyeon ),박수헌 ( Park Su Heon ),한남익 ( Han Nam Ig ),윤승규 ( Yun S 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 간경변 환자에서 단백질-칼로리 영양실조가 흔하다. 특히 현증 간성뇌증 환자의 경우 단백질 제한을 하는 경우가 많아 영양실조가 더욱 악화되고 예후에도 영향을 미칠 것으로 생각된다. 이에 간성뇌증 환자의 영양상태 평가에 중요한 지표를 알아보고자 하였다. <대상 및 방법> 총 25명의 간경변 환자를 대상으로 간성뇌증의 병력이 없는 13명을 간경변군, 현증 간성뇌증이 있거나 간성뇌증의 병력이 있는 간경변 환자 12명을 간성뇌증군으로 하여 혈청 생화학적
만성 바이러스성 간염 환자의 간조직에서 Fas 항원의 면역조직화학적 관찰
최상욱,양진모,김병욱,정규원,최황,선희식,한남익,이창돈,차상복,김성수,남순우 대한소화기학회 1999 대한소화기학회지 Vol.34 No.5
Background/Aims: Fas was proposed as a protein that triggers or mediates apoptosis combining with Fas ligand on cytotoxic T lymphocytes. The mechanism of hepatic injury in chronic viral hepatitis may also include Fas-mediated apoptosis. We evaluated the expression patterns of Fas in liver tissues of patients with chronic viral hepatitis. Methods: Eighty-six liver biopsy samples from patients with chronic viral hepatitis (64 HBsAg positive, 22 anti-HCV positive) were immunohistochemically stained for Fas. Histological findings were evaluated according to the Knodell's Histologic Activity Index (HAI). Results: Incidence of Fas-positive hepatocytes in chronic viral hepatitis was 75.5% (75% in type B and 77.2% in type C). Hepatocellular localization of Fas expression in hepatitis B was the membrane in 89.5% of the patients and the cytoplasm in 87.5% of them. In hepatitis C, it was the membrane in all cases and the cytoplasm in 76.4%. Fas positive hepatocytes were the most frequently detected in periportal area. The prevalence of Fas expression was 100% in chronic active hepatitis of both type B and type C, while in chronic persistent hapatitis, it was 68.8% in type B and 73.3% in type C. There was a positive relationship between the grade of Fas expression and HAI score. Conclusions: Hepatocytic apoptosis associated with Fas expression may play a role in the pathological mechanism of the hepatic injury in chronic viral hepatitis.