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      • 가정에서의 전기안전 대책

        남상윤 대한전기협회 2000 전기저널 Vol. No.

        생활수준의 향상으로 일반가정에서 사용하는 전기용품의 종류도 무척 다양해졌으며 사용량도 급격히 증가되어 이로 인한 전기재해(화재, 감전)가 끊이지 않고 있다. 행정자치부 화재통계 연보에 따르면 ''99년도 총 화재발생건수 33,856건 중 전기로 인한 화재가 11,204건으로 33.1$\%$의 높은 점유율을 보이고 있어 일반가정에서의 전기안전 생활화가 절실히 요구되고 있는 실정이다. 일반 가정생활에서 편리하게 사용하고 있는 전기를 보다 더 안전하게 사용하기 위해서 우리 모두가 꼭 알아두어야 할 전기설비에 관한 기초상식, 전기사고의 종류와 예방대책, 정전 시 대처요령 등을 알아본다.

      • KCI등재후보

        Exposure to genistein does not adversely affect the reproductive system in adult male mice adapted to a soy-based commercial diet

        남상윤,이범준,강종구,정은용,윤영원,백인정,윤정민,이윤복,손현수,이재용,김강성 대한수의학회 2004 Journal of Veterinary Science Vol.5 No.3

        Genistein, a soybean-originated isoflavone, is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of male reproductive system. Five-week-oldICR mice were purchased and fed with a soybean-based Purina Chow diet until 6 months of age. The animals were xposed by gavage to genistein (2.5 mg/kg/day) or 17β-estradiol (7.5 μg/kg/day) for five weeks. Corn oil was used for the negative control. The animals were fed the caseinbasedAIN-76A diet throughout the experimental periods. There were no significant differences in body and organ weights of mice among experimental groups. Nosignificant differences in sperm counts and sperm motile characteristics were found between the control and the genistein groups. Treatment of 17β-estradiol caused asignificant decrease in epididymal sperm counts compared to the control (p < 0.05). The level of phospholipid hydroxide glutathione peroxidase in the epididymis ofmice exposed to genistein was significantly higher than that of the control mice (p < 0.05). 17β-estradiol treatment caused a reduction of germ cells in the testis andhyperplasia of mucosal fold region in the prostate of mice. Genistein treatment did not cause any lesion in the testis,epididymis, and prostate. These results suggest thatdietary uptake of genistein at adult stage of life may not affect male reproductive system and functions.

      • KCI등재

        랫드의 화상모델에서 전복껍질과 참기름의 치료효과

        남상윤,이범준 한국수의공중보건학회 2003 예방수의학회지 Vol.27 No.2

        This study was performed to investigate effect of a mixture of ear shell ash and sesame oil on bum in a Sprague-Dawley rat model. Sixty male rats were assigned to 3 experimental groups including negative and positive control groups, and a test material group. The test compound was applied to formally once a day f3r 7 days. Distilled water was applied as a relative positive control. After dermal applications f3r 3, 5, and 7 days, blood hematology and skin histopathological examination were performed. Inorganic compounds in ear shell ash was mainlycalcium oxide(92%). The body weights of positive control rats were significantly low at day 3, 5, and 7 as compared with negative control and test material groups. There was no significant difference in body weight between negative control and test material groups throughout the experimental period. WBC counts in both positive control and test material groups were higher than those in negative control group, indicating progress of inflammatory reaction. In differential leucocyte count, panulocytes including neutrophils and eosinophils were higher in positive control and test material groups than negative control group. Hemoglobin and hematocrit values were lower in homing model rats, probably resulting from hemorrhage in dermis. Skin histopathology showed severe full thickness coagulative necrosis in epidermis and dermis, hemorrhage and infiltration of leucocytes in dermis in both positive control and test material groups throughout the experimental period. These results indicate that the test materials, ear shell ash plus sesame oil, moderately ameliorate homing probably concerning to process of skin injury repair including inflammation and fibrosis

      • KCI등재

        C57BL6 생쥐에서 NDM 헤어토닉의 모발성장 촉진 효과

        남상윤,문준환,윤영원,백인정,연정민,류광철,이범준 대한약학회 2004 약학회지 Vol.48 No.2

        NDM hair tonic is composed of several plant extracts which are known to be used in oriental medicine. This study was carried out to investigate the effect of NDM hair tonic on hair regrowth in an alopecia model of C57BL6 mice. Hair of six-weeks old mice were trimmed by electric clippers and electric shavers, so as not to damage the skin. The next day, mice without visible scraches were selected, randomized and separated in groups of 6 mice. There were four experimental groups including saline (negative control), 50% ethanol (vehicle control), 3% minoxidil (MXD), and NDM tonic. The test compounds were topically treated with 0.15 $m\ell$ per mouse per day for 2 weeks. The hair regrowth was determined photographically and histologically and the quantity of endocrine factors, IGF-1 and TGF-$\beta$, in the skin of mice was measured by PCR. No clinical signs were found in all animals. The topical treatment of NDM tonic for 2 weeks to dorsal skin accelerated hair regrowth faster than either the controls or MXD treatment. The NDM tonic treatment also promoted hair follicle development and elongation as compared with the controls or MXD treatment. Both NDM tonic and MXD treatment significantly increased the expression of IGF-1 and TGF-$\beta$ in the skin of C57BL6 mice as compared with the controls (p<0.05). These results suggest that NDM tonic has a hair growth activity and be useful for the treatment of baldness or alopecia.

      • SCOPUSKCI등재
      • KCI등재후보
      • 열상 처치 마우스에서 백혈구 분포의 변화

        남상윤 전주대학교 자연과학종합연구소 1997 전주대학교 자연과학연구소 학술논문집 Vol.10 No.1

        It has been well documented that global suppression of the immune responses occurs after thermal injury and these changes resulted in decreased resistance to infection, which is a leading cause of high mortality of burn patients. Regarding to numerical changes of lymphocytes related to this immune defects, a lot of controversial results have been reported. In this study, the distribution of leukocytes was investigated in thermally injured mice. Mice (Balb/c) were anesthetized by intraperitoneal injection of 2,2,2-tribromoethanol and thermally injured by immersion of hair-removed dorsal skin (15% total body surface) in a boiling water bath (ca. 96℃). Mortality of mice injured for 7, 9 and 11 seconds was <5%, 25 and 100%, respectively. Almost all of mice injured for 7 seconds recovered from wounds after 40 days postinjury, which were used for all experiments. Significant decrease of peripheral blood leukocyte (PBL), lymph node cell (I,NC) and spleen cell (SPC), thymocyte(Thy) numbers was observed at day 2 and followed by gradual increase to (PBL) or over normal level (LNC and SPC) until day 24 of injury, whereas thymocytes sustained lowered numbers. Such increase of cell number coincided with higher proportion of PMN, particularly in spleen (5% vs 30%). Reduction of lymphocyte proportion was due to relative increase of PMN number, not the decrease of absolute number of lymphocytes. This increasing number of PMN may explain the diminished immune response, assessed with whole spleen cells in a murine model. These results also suggest that trafficking of PMN may be important for the recovery from thermal trauma. In addition, the Th/Ts ratio of injured mice was comparable to that of control group, which is not likely to be a critical factor leading to alteration of immunity in thermal injury.

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