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인유두종 바이러스검출을 이용한 자궁경부 상피내종양의 분자생물학적 진단방법
남궁성은,박종섭,김용욱,허수영,박동춘,정인광,나윤택,김차주 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.11
This study analysed 83 cervical neoplastic patients with HPV-16 DNA detected by PCR by in the patients of the Department of Obstetrics and Gynecology, Kangnam St. Marys Hospital, Catholic University Medical College, comparing the histopathology from Papanicolaou smear and colposcopic guided biopsy, quantitative evaluation of HPV DNA by Hybrid Capture test and the preservation of HPV-16 E2 DNA with PCR. Our analysis revealed: 1. Atypical transformation zone seen by colposcopy was divided into three groups, one where zone covered less than 25%, one between 25~50% and one greater than 50%. When compared with histopathologic findings, CIN and CIN III were present in 31%(10/32), 31 %(8/26), and 75%(18/24) respectively. 2. Comparing of cervical histopathologic results with HPV DNA amounts, viral titer greater than 5.0 was found in non-specific cervicits(13.3%; 4/30), HPV+CIN I(31.3%; 5/16) and CIN II + III(69.4%; 25/36). 3. Comparing of cervical histopathologic results with the preservation of intact HPV-16 E2 DNA using PCR, E2 DNA was present in non-specific cervicitis(7%; 2/30), HPV+CIN I(0%;0/16), and CIN III + III(47%; 17/36). 4. The presence of HPV-16 E2 DNA was compared with HPV DNA titer. When HPV-16 E2 DNA was present, titer was greater than 5.0 in 89%(17/19), while HPV-16 E2 DNA was absent, titer was greater than 5.0 in only 27%(17/63). Our analysis revealed that high HPV DNA titer and complete HPV-16 E2 DNA correlated well with advanced grade of CINs. In conclusion, this result suggest that HPV DNA titer and HPV-16 E2 DNA presence can clinically assist in predicting the prognosis of CINs.
지속적 종양 표지자 상승을 보인 경계성 점액성 종양에서 기원한 침윤성 점액성 낭선암종의 1예
남궁성은,한찬희 대한부인종양학회 2007 Journal of Gynecologic Oncology Vol.18 No.3
Mucinous tumors account for 10-15% of all epithelial of ovarian tumors, and 40% of them are borderline. Not many factors are known about progression into mucinous carcinoma of borderline ovarian tumors. The incidence of progression into invasive carcinoma is reported about 2.4% for borderline serous tumous, and 1.6% for borderline mucinous ovarian tumors. Mucinous tumors often exhibit a morphologic continuum of beningn, borderline, and invasive, so a pathologist should pay attention when examine the pathologic specimen not to miss carcinoma. This is the case of 54 female patients who developed invasive mucinous ovarian carcinoma 6 months after surgical treatment of borderline mucinous ovarian tumour. 경계성 난소종양은 상피성 난소종양의 10-20%로 예후는 매우 양호하고 경계성 난소 종양중 점액성 난소 종양은 약 40%를 차지하고 있다. 경계성 난소종양의 침윤성 난소암으로 진행에 대해서는 많이 알려져 있지는 않으나, 빈도가 2% 정도고 보고되고 있고, 위험 인자에 대해서 많은 것이 알려져 있지는 않았다. 점액성 난소종양의 경 우 양성병변에 인접하여 악성병변이 존재하는 등 병리학적으로 이질성을 지니고 있어 검체표본의 체취시 주의 를 요한다. 본 예는 경계성 점액성 난소종양에서 수술시 난소 외 복막 및 장간막 등에는 다른 병변을 보이지 않 아 수술시 복강내 세포검사, 전자궁적출술과 양측 난관난소절제술을 병기결정 수술로 시행하였던 환자에서 수 술 6개월 후 침윤성 점액성 난소암으로 진행되었던 경우로 경계성 난소 종양 수술시 근치적 수술과 점액성 난 소 종양의 병리학적 성질에 대해서 논하고자 본 예를 제시하는 바이다.