CPAP 사용으로 유발된 조증 삽화 1예

나해란,강은호,유범희,Na, Hae-Ran,Kang, Eun-Ho,Yu, Bum-Hee 대한불안의학회 2008 대한불안의학회지 Vol.4 No.2

Continuous positive airway pressure (CPAP) has been known as a safe and effective therapy for the patients with obstructive sleep apnea (OSA). Previous studies on CPAP treatment have often reported significant improvement in mood state in those patients. However, there are very few reports on its potential to induce manic or hypomanic episode in the patients with OSA. We report a case of 34-year-old patient with OSA who developed manic and hypomanic episodes consecutively after CPAP treatment with facial mask. We suggest that CPAP treatment could induce a manic or hypomanic episode in patients with obstructive sleep apnea.

The Genetic Basis of Panic Disorder

나해란,강은호,이재헌,유범희 대한의학회 2011 Journal of Korean medical science Vol.26 No.6

Panic disorder is one of the chronic and disabling anxiety disorders. There has been evidence for either genetic heterogeneity or complex inheritance, with environmental factor interactions and multiple single genes, in panic disorder’s etiology. Linkage studies have implicated several chromosomal regions, but no research has replicated evidence for major genes involved in panic disorder. Researchers have suggested several neurotransmitter systems are related to panic disorder. However, to date no candidate gene association studies have established specific loci. Recently, researchers have emphasized genome-wide association studies. Results of two genome-wide association studies on panic disorder failed to show significant associations. Evidence exists for differences regarding gender and ethnicity in panic disorder. Increasing evidence suggests genes underlying panic disorder overlap, transcending current diagnostic boundaries. In addition, an anxious temperament and anxiety-related personality traits may represent intermediate phenotypes that predispose to panic disorder. Future research should focus on broad phenotypes, defined by comorbidity or intermediate phenotypes. Genome-wide association studies in large samples, studies of gene-gene and gene-environment interactions, and pharmacogenetic studies are needed.

이중언어자에서 보인 두 형태의 실어증 : 증례보고 A Case Report

나해리,이정욱,박성민,박수열,권순용,이현정 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.2

Since many people in Korea know more than one language, bilingual aphasia is an important line of research in clinical and theoretical neurolinguistics. Nowadays we meet many people who speak other languages along with Korean, who are immigrants from foreign countries, especially from China. Differential recovery of language affected by an aphasic deficit is documented. In the present work, we introduced a patient with bilingual aphasia who showed different recovery patterns in Korean and Chinese. A 66-year-old man was presented with language disturbance and right hemiplegia. On past medical history, he had received a hematoma evacuation through burr-hole due to left basal ganglia hemorrhage. After the event, he showed nearly global aphasia in Korean, but he showed minimally preserved language function on comprehension and fluency in Chinese. This result suggests that aphasia in bilingual subject may show different pat-terns of recovery between two languages.

건강한 독거노인에게서 회복탄력성의 외로움에 대한 사회적 지지의 매개 효과

나해인,최소연,엄태림,김태희 대한노인정신의학회 2019 노인정신의학 Vol.23 No.2

Objective:This study aims to identify the impact of social support on the relationship between loneliness and resilience for the elderly who are mentally sound, financially stable and living in a single household setting. Methods:A sample of 197 mentally healthy (Mini-Mental State Examination for Dementia Screening ≥-1.5 standard deviation and Geriatric Depression Scale <10) community-dwelling elderly 65 years of age or older was recruited. Multidimensional individual and interpersonal resilience measure, Medical Outcomes Study Social Support Survey, and University of California, Los Angeles Loneliness Scale were used followed by structured face to face interviews. Descriptive statistics, t-test, analysis of variance, Pearson correlation, and stepwise regression analysis were used for data analysis. Results:The mean score of Resilience was 70.7 (±11.7)/111, social support was 60.2 (±21.4)/95, and Loneliness was 38.5(±11.9)/80. For the Resilience, there was a statistically significant correlation between loneliness (r=0.56, p<0.01) and social support (r=0.72, p<0.01). Hierarchical analysis shows that social support completely mediates the effect of resilience on loneliness. Stepwise regression analysis represents affection emotional support and positive social interaction have the highest descriptive power. Conclusion:In conclusion, social support fully mediates the impact of resilience on loneliness. The findings suggest developing social support intervention programs, especially which can give emotional support and positive social interaction, is effective and crucial to decrease loneliness for elderly who are living alone.

How MBTI affects successful life

나해란 ( Hae-ran Na ) 대한피부과학회 2024 대한피부과학회 학술발표대회집 Vol.75 No.1

중증 대뇌반구경색 환자의 사망률과 초기 예후인자

나해리,강우열,정승철,유경호,마효일,이병철 대한노인병학회 2001 대한노인병학회지 Vol.5 No.2

주택화재보험 활성화 방안

나해인,Na, Hae-In 한국화재보험협회 1999 防災와 保險 Vol.80 No.-

한국인 치매환자에서의 리바스티그민 패취 사용 경험; 예비 연구

나해리,강현석,김상석,한설희 대한치매학회 2009 Dementia and Neurocognitive Disorders Vol.8 No.1

While rivastigmine transdermal patch has consistently demonstrated better tolerability and similar efficacy compared to conventional rivastigmine capsules in clinical studies; it has not been specifically evaluated in Korean dementia patients. From February to November 2008, 94 patients with dementia and mild cognitive impairment (MCI) were treated with rivastigmine transdermal patch at Konkuk University Hospital and Bobath Memorial Hospital. To evaluate the safety and tolerability in Korean patients with dementia and MCI, we reviewed the clinical data of the patients. The participating subjects were diagnosed as Alzheimer’s disease (n= 34), mild cognitive impairment (n=5), vascular dementia (n=26), Parkinson’s disease dementia (n=13), dementia with Lewy body (n=3), frontotemporal dementia (n=2) and other types of dementia (n=11). All of the patients were followed within 3 months (90±14 days), in terms of evaluating adverse events. Adverse events occurred in 11 cases (11.7%) and adherence of the patch was good in 91 cases (96.8%). Most of the participants showed clinical improvement similar to other acetylcholinesterase inhibitors (AchEIs). The most common adverse effects were skin-related problems including simple skin irritation, itching sensation, erythematous lesion, patch marks (contact dermatitis) and even severe symptoms mixed with all of the above (allergic contact dermatitis), occurred in eight cases (8.5%). Gastrointestinal (GI) discomfort was reported in two cases (2.1%). Among patients who stopped rivastigmine transdermal patch, six patients (6.3%) withdrew due to adverse events. Rivastigmine transdermal patch provides a good tolerability profile in treating Korean patients with the various subtypes of dementia and may be effective for the improvement of cognitive function in Korean patients with Alzheimer’s disease. While rivastigmine transdermal patch has consistently demonstrated better tolerability and similar efficacy compared to conventional rivastigmine capsules in clinical studies; it has not been specifically evaluated in Korean dementia patients. From February to November 2008, 94 patients with dementia and mild cognitive impairment (MCI) were treated with rivastigmine transdermal patch at Konkuk University Hospital and Bobath Memorial Hospital. To evaluate the safety and tolerability in Korean patients with dementia and MCI, we reviewed the clinical data of the patients. The participating subjects were diagnosed as Alzheimer’s disease (n= 34), mild cognitive impairment (n=5), vascular dementia (n=26), Parkinson’s disease dementia (n=13), dementia with Lewy body (n=3), frontotemporal dementia (n=2) and other types of dementia (n=11). All of the patients were followed within 3 months (90±14 days), in terms of evaluating adverse events. Adverse events occurred in 11 cases (11.7%) and adherence of the patch was good in 91 cases (96.8%). Most of the participants showed clinical improvement similar to other acetylcholinesterase inhibitors (AchEIs). The most common adverse effects were skin-related problems including simple skin irritation, itching sensation, erythematous lesion, patch marks (contact dermatitis) and even severe symptoms mixed with all of the above (allergic contact dermatitis), occurred in eight cases (8.5%). Gastrointestinal (GI) discomfort was reported in two cases (2.1%). Among patients who stopped rivastigmine transdermal patch, six patients (6.3%) withdrew due to adverse events. Rivastigmine transdermal patch provides a good tolerability profile in treating Korean patients with the various subtypes of dementia and may be effective for the improvement of cognitive function in Korean patients with Alzheimer’s disease.

Cognitive Therapy Combined with Drug Treatment in Patients with Alzheimer’s Disease: A Neuropsychological and Positron Emission Tomography Investigation, a Pilot Study

나해리,김상윤,Yu Kyeong Kim,박문호,Sung Tae Cho,Woo Jung Kim 대한치매학회 2015 Dementia and Neurocognitive Disorders Vol.14 No.2

BackgroundCognitive therapy may have therapeutic benefit in patients with early Alzheimer’s disease (AD). Case ReportThis was a 12-week, single-blind pilot study of 4 patients with AD. The cognitive therapy included exercises for orientation to time and place; memory training, including face-name association, object recall training, and spaced retrieval; visuo-motor organization using software; similarity and ruled based categorization; and behavior modification and sequencing (e.g., making change, paying bills). The regional cerebral metabolic abnormalities and the effects of treatment on cortical metabolic responses were evaluated using 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (PET). After 12 weeks, the participants showed slight improvement in some neuropsychological measures, and three of them showed increased regional cortical metabolism on brain PET studies. ConclusionsCognitive therapy may stabilize or improve cognitive and functional performance of patients with early AD and increase regional cortical metabolism of the patients’ brain. Background Cognitive therapy may have therapeutic benefit in patients with early Alzheimer’s disease (AD). Case ReportThis was a 12-week, single-blind pilot study of 4 patients with AD. The cognitive therapy included exercises for orientation to time and place; memory training, including face-name association, object recall training, and spaced retrieval; visuo-motor organization using software; similarity and ruled based categorization; and behavior modification and sequencing (e.g., making change, paying bills). The regional cerebral metabolic abnormalities and the effects of treatment on cortical metabolic responses were evaluated using 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (PET). After 12 weeks, the participants showed slight improvement in some neuropsychological measures, and three of them showed increased regional cortical metabolism on brain PET studies. ConclusionsCognitive therapy may stabilize or improve cognitive and functional performance of patients with early AD and increase regional cortical metabolism of the patients’ brain.

방사선 치료 후 발생한 모야모야현상을 동반한 뇌혈관폐색증

나해리 대한뇌졸중학회 2000 Journal of stroke Vol.2 No.2

Background : The radiation-induced occlusive vasculopathy has been known as the one of the side effects of radiation therapy but rarely involves intracranial large arteries. We present a case of acute stroke with progressive occlusive disease of the intracranial large arteries with Moyamoya phenomena induced by radiation therapy. Case Report : A 40 year-old man presented with left hemiparesis. He had no risk factors for stroke except having undergone radiation therapy for pituitary adenoma 6 years ago. On T2WI, multiple hyperintense lesions were noted in right MCA territory. Cerebral angiography revealed complete occlusion of both middle cerebral arteries which were patent on the previous MRI performed at the time of surgery abnormal vascular networks. Conclusion : We suggest that irradiation is a possible cause of progressive cerebrovascular occlusive disease. Therefore, careful consideration for radiation therapy is needed especially in benign natured tumor and cerebral angiography is indicated, when the patient develops cerebral ischemic symptoms. Korean Jourmal of Stroke 2000;2(2): 221~224