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김현학,정현아,김경헌,김정한,이석구,Kim, Hyun-Hahk,Jeong, Hyeon-A,Kim, Kyung-Hun,Kim, Jung-Han,Lee, Suk-Koo 대한소아외과학회 2001 소아외과 Vol.7 No.1
The aims of this study were to evaluate the prognostic predictabilities of the risk classifications (Waterston, Montreal, and Spitz), preoperative treatment of pneumonia and the length of esophageal gap in esophageal atresia. Twenty-five cases of esophageal atresia were reviewed retrospectively. The data was analyzed with Likelihood ratio test for trend and Fisher's exact test. Survival rates were 100.0 % in group A and B, and 60.0 % in group C according to Waters ton classification (p=0.027). By Montreal classification, 95.7 % in group I and 50.0 % in group II (p=0.086). By Spitz classification, 95.5 % in group I and 66.7% in group II (p=0.159). The survival rate was 85.7 % in the patients with pneumonia preoperatively treated and 94.4% in the patients without pneumonia. The difference was not significant (p=0.490). Survival rate in the patients with long gap (${\geq}$3cm) was 50.0 % and 100.0 % in patients with short gap (<3cm) with significant difference (p=0.020). The Waterston classification could be modified into two groups because the prognosis of both group A and B were the same. Preoperative pneumonia does not seem to be a risk factor. The length of the esophageal gap showed prognostic value.
출산이 부모의 흡연 행태에 미치는 영향: 이론적 분석 및 패널 자료를 이용한 실증분석
김현재(Hyeon-Jae Kim),최한실(Han-Sil Choi) 한국경제연구학회 2020 한국경제연구 Vol.38 No.2
본 연구는 출산이 부모의 흡연 행태에 미치는 영향을 분석하였다. 부모의 흡연에 따른 간접흡연이 자녀의 건강에 부정적인 영향을 미치는 것은 널리 알려져 있는 사실이며 이에 관한 수많은 연구들이 있어 왔다. 그러나 반대로 자녀의 유무 혹은 출산이 부모의 흡연 행태에 미치는 영향을 분석한 연구는 지금까지 전무하다. 이를 분석하기 위해 이론 모형을 이용해 출산이 부모의 흡연 행태에 미치는 영향에 관한 가설을 설정하고, 패널 데이터를 이용한 실증분석을 통해 검정하였다. 실증분석 결과, 남성의 경우 출산 후 흡연량에 유의한 차이가 없었다. 여성의 경우, 출산 후 4년 동안은 출산 효과가 흡연량을 감소시키고 그 이후에는 출산 전과 비슷한 수준으로 돌아가는 결과를 보여 성별에 따라 출산이 흡연 행태에 미치는 효과의 방향이 상반되었다. This study analyzed the effect of childbirth on parental smoking behavior. It is well known that secondhand smoke caused by parental smoking has a negative effect on the health of the child, and there have been numerous studies. On the contrary, there have been no studies analyzing the effects of parental status or childbirth on parental smoking behavior. In order to analyze the parental smoking behavior, hypotheses about the effects of childbirth on smoking behavior of parents were established using theoretical model, and tested through empirical analysis using panel data. As a result of empirical analysis, there was no significant difference in postpartum smoking in men. In case of women, the fertility effect reduced smoking during four years after giving birth and then returned to levels similar to those before giving birth. By gender, the effects of childbirth on smoking behavior were contradictory.
2-Acetylaminofluorene의 투여량에 따른 쥐간의 Monooxygenase에 관한 쇠기름 및 콩기름의 영향
김현덕,김현아,한성림,김경민,장경자,최혜미,Kim, Hyeon-Duck,Kim, Hyeon-A,Han, Sung-Nim,Kim, Kyung-Min,Jang, Kyung-Ja,Choi, Hay-Mie 생화학분자생물학회 1993 한국생화학회지 Vol.26 No.1
이유된 Sprague Dawley종 숫쥐를 식이 지방의 종류에 따라 쇠기름군과 콩기름군으로 나누고, 식이지방은 실험식이의 15% 수준으로 하여 8주 동안 사육하였으며 9주째 체중 kg당 25mg과 100mg의 2-AAF를 각각 3일간 연속 복강주사로 투여하고 다음날 희생시켰다. 간 microsome으로부터 cytochrome P-450, cytochrome bs 함량, NADPH-cytochrome P-450 reductase 활성도, lipid peroxide 함량을 측정 비교하였다. 25mg AAF를 투여했을 때 cytochrome P-450 lipid peroxide 함량은 콩기름군이 쇠기름군보다 유의적 (p<0.05)으로 높았고, 100mg AAF를 투여 했을 때는 cytochrome P-450 함량은 감소했지만 cytochrome $b_5$ 함량은 증가하였다. NADPH-cytochrome P-450 reductase 활성도는 식이지방의 종류에 따라서는 차이가 없었으나 두 식이군 모두 2-AAF 투여량이 증가함에 따라 상승되었다. 이 결과로부터 식이지방의 불포화도가 높을수록 cytochrome P-450의 유도도 뿐아니라 100mg 2-AAF에 의한 손상도 촉진되는 것으로 보여지며, 지질과산화물과는 크게 연관성을 나타내지 않았다. Weanling Sprague Dawley male rats were fed the diet containing 15% beef tallow and soybean oil for 8 weeks. At 9th week, 2-AAF was injected everyday for 3 days by intraperitoneally at the levels of 25 mg and 100 mg/㎏ body weight and sacrificed next day. Cytochrome P-450 and cytochrome $b_5$ contents, NADPH-cytochrome P-450 reductase activity, lipid peroxide values were determined from isolated microsome. Cytochrome P-450 contents and lipid peroxide values were significantly higher in soybean oil group than beef tallow group by 25 mg 2-AAF injection, and cytochrome P-450 contents decreased but cytochrome $b_5$ contents increased in soybean oil group by 100 mg 2-AAF injection. NADPH-cytochrome P-450 reductase activities were not significantly different between dietary groups, but were elevated by 2-AAF injection and positively correlated to the levels of 2-AAF in each dietary group. These results suggest that soybean oil is more susceptible to the damage as well as induction of cytochrome P-450 by 2-AAF, and that lipid peroxide is not positively correlated to the cytochrome P-450 contents.
2 - Acetylaminofluorene 의 투여량에 따른 쥐간의 Monooxygenase 에 관한 쇠기름 및 콩기름의 영향
김현덕,김현아,한성림,김경민,장경자,최혜미 ( Hyeon Duck Kim,Hyeon A Kim,Sung Nim Han,Kyung Min Kim,Kyung Ja Jang,Hay Mie Choi ) 생화학분자생물학회 1993 BMB Reports Vol.26 No.1
Weanling Sprague Dawley male rats were fed the diet containing 15% beef tallow and soybean oil for 8 weeks. At 9th week, 2-AAF was injected everyday for 3 days by intraperitoneally at the levels of 25 ㎎ and 100 ㎎/㎏ body weight and sacrificed next day. Cytochrome P-450 and cytochrome b_5 contents, NADPH-cytochrome P-450 reductase activity, lipid peroxide values were determined from isolated microsome. Cytochrome P-450 contents and lipid peroxide values were significantly higher in soybean oil group than beef tallow group by 25 ㎎ 2-AAF injection, and cytochrome P-450 contents decreased but cytochrome b_5 contents increased in soybean oil group by 100 ㎎ 2-AAF injection. NADPH-cytochrome P-450 reductase activities were not significantly different between dietary groups, but were elevated by 2-AAF injection and positively correlated to the levels of 2-AAF in each dietary group. These results suggest that soybean oil is more susceptible to the damage as well as induction of cytochrome P-450 by 2-AAF, and that lipid peroxide is not positively correlated to the cytochrome P-450 contents.