正常 및 異常姙娠 血淸中 Cystine Aminopeptidase의 活性度에 關한 硏究

金顯燦 대한산부인과학회 1975 Obstetrics & Gynecology Science Vol.18 No.1

복식 전자궁적출술시 예방적 Fasigyn의 효과

김현찬,제구화,김기태,박호,조종희,최상림 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.6

인제대학교 의과대학부속 부산백병원에서 복식 전 자궁적출술시 Fasigyn을 예방적으로 투여하여 대조군과 비교하여 그 효과를 분석한바 다음과 같은 결과를 요약하고 결론을 내릴 수 있었다. 1. 열성이환의 빈도와 추가적인 다른 항생제투여가 필요한 경우가 투약군에서 대조군에 비하여 반감하였다. 2. 복벽창상감염은 경미한 경우이었고 빈도가 높지 않았으며, 대조군과 투약군에서 빈도는 별 차이가 없었다. 3. 골반감염(골반 봉과직염 및 질구개 봉과직염)의 빈도는 투약군과 대조군에서 큰 차이가 없었으며, 양군에서 골반농양의 경우는 1례도 없었다. 이는 아마도 질구개를 개방한 술식과 더불어 열성이환을 보인 예에 추가적으로 다른 복합항생제를 사용한 것에 기인한 것으로 사료된다. 4. 뇨로감염의 빈도는 비교적 높은 편이었고, 투약군에서 대조군보다 그 빈도가 낮았다. 저자들이 시행한 수술 전처치 및 수술방식에는 대조군과 투약군에서 비교적 열성이환의 빈도가 다른 보고자에 비하여 낮고 중한 골반감염과 이로인한 문제가 될만한 후유증으로 입원이 연장된 예는 없었다. 저자들이 시행한 술식과 더불어 비용이 적게들고 간편한 예방적 단회경구 Fasigyn의 투여는 다소 열성이환과 비뇨기감염의 빈도를 저하 시킨고로 그 효과를 인정할 수 있다고 생각되며, 환자를 선별하여 예방적으로 투여하는 것이 좋을 것으로 생각된다. 그러나 비뇨기감염의 빈도가 비교적 높은 것으로 보아 향후 이에 대한 개선된 대책이 요구된다. In 100 patients undergoing elective abdominal hysterectomy, a double blind study was undertaken to evaluate the efficacy of Fasigyn treatment in diminishing the postoperative infection rate. The study group (n= 50) received a single dose of 2.0 gm Fasigyn p.o. before 12 hours preoperatively while the control group (n= 50) did not. The two groups of patients, 50 in each, were comparable with regard to age, anemia, pathologic condition, length of operation, blood loss and indication of htsterectomy, etc. The febrile morbidity was noticed in 6 % and 12 % of the study and control groups, respectively. Significant pelvic infectious complications (pelvic and vaginal cuff cellulitis) were observed in 6 % of the control group and 4 % of the study group but no case of pelvic abscess was encountered. Abdominal wound infection, moderate degree, was found in 2 % of the control group and 4 % in the study group. Urinary tract infection, the most frequent complication in this study, was found in 26 % of the control and in 16 % of the study group. The result of this study indicated that oral preoperative single dose Fasigyn prophylaxis reduced modestly the over all rate of febrile morbidity and urinary tract infection, but no significant difference of pelvic and abdominal wound infection rate was found between two groups. No difference of hospital stay was found between two groups but more case of infectious complication in the group were treated by additional other antibiotics. Because the incidence of febrile morbidity is relatively low and serious consequences of pelvic and abdominal infection are rare in this study, the routine Fasigyn prophylaxis in all low risk patients undergoing elective abdominal hysterectomy, although somewhat effective, is probably not always necessary, but it seems to be prudent to give additional measures to reduce postoperative urinary tract infection.

저 체중아의 산과적 요인에 관한 임상적 고찰

김현찬 부산의대 1978 부산의대잡지 - 부산대학교 의과대학 Vol.18 No.2

산부인과 영역의 Shock의 진단과 처치

김현찬 釜山醫師會 1979 釜山醫師會誌 Vol.15 No.11

Obstetric Hemorrhage

김현찬 中央醫學社 1985 中央醫學 Vol.48 No.6

惡性卵巢腫瘍의 臨床病理學的 考察

金顯燦 大韓産婦人科學會 1968 大韓産婦人科學會雜誌 Vol.11 No.12

제왕절개 분만후 모성열성이환에 관한 임상적고찰

김현찬,성문수,박호,조종희 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.3

제왕절개분만후 모성열성이환에 관여하는 위험요인을 조사하고자 최근 3년간(1983년 8월1986년 7월) 인제의과대학부속 부산백병원 산부인과에서 시행한 제절 508예의 임상기록을 조사하여 일련의 임상적상황과 열성이환과의 관계를 분석한바 다음과 같이 요약할 수 있었다. 1. 제절후 총열성이환의 빈도는 12.0%(61/508)이었다. 2. 응급, 일차, 초산, 조산의 제절, 빈혈 및 수혈, 파막시간의 연장, 분만진통이 있는 경우, 전신마취 등 각각의 경우에 제절후 모성열성이환율은 보다 높게 나타났으며, 위험요인이 중복되었을 경우(파막 및 진통시간의 연장) 열성이환의 위험은 더욱 증가되었다. 3. 위험요인(진통 및 파막)이 중복된 경우에 예방적 항생제를 사용하지 않고 제절한 경우에는 21.7%의 높은 열성이환율을 보였다. 4. 열성이환의 원인을 조사한바 자궁내막염(42.7%), 비뇨기감염(16.4%), 수술부위감염(16.4%), 불명열(13.0%), 정맥염(6.6%), 상기도감염(4.9%)의 순으로 나타났다. During a 3-year period, 508 women delivered of their infants by Cesarean section were analyzed to determine the type and rate of maternal febrile morbidity, and to identify risk factors which predispose to it. The overall febrile morbidity rate was 12.0 % and the most common one was endometritis (42.7 %), in order, wound infection and urinary tract infection (16.4 %, respectively), FUO (13.0 %), phlebitis (6.6 %), and URI (4.9 %). Significant factors that predispose to febrile morbidity were Cesarean section in case of emergency, primary, primigravida, preterm, prolonged duration of membrane rupture, and labor pain, anemia or transfusion, general anesthesia, respectively. Patient with combined risk factors (labor and membrane rupture) had and increased febrile morbidity (21.7 %). Based on these findings, the followings seem to be suggested; Attempt to reduce emergency operation, and emergency operation should be performed as soon as possible during delivery. Patient with multiple combination of risk factors may benefit from antibiotic prophylaxis.

Transparent and Flexible Photon Sieve Made with Cellulose Nanofiber by Micro-Nano Structure Molding

김현찬,Lindong Zhai,Pooja S. Panicker,김현정,David MacDonnell,김재환 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.4

Conventionally, the photon sieve (PS) was made of chrome-coated fused silica and quartz plates. However, fused silica and quartz plates have a size limitation due to their weight and fragility. A membrane PS is attractive since it is lightweight, large size, flexibility and deployable. This paper demonstrates the new concept of membrane PS based on cellulose nanofiber (CNF). The CNF-based PS (CNF-PS) is transparent, flexible, lightweight, and has high strength and toughness. This study highlights the PS fabrication on a CNF fi lm using a micro-nano structure molding technique and its structural stability in an external environmental change. For the first time in literature, through a high vacuum (5 × 10 –8 Torr) environment test, it was shown that CNF has emerged as a promising optical material. Furthermore, the prepared CNF-PS exhibited high beam quality. This study explained the complete research strategy from the isolation of cellulose nanofibers to its PS application. The new concept of CNF-PS will accelerate its broad application to thin and compact photonic devices.

약물에 의한 분만유도

김현찬 中央醫學社 1978 中央醫學 Vol.34 No.6

자궁경부 편평상피성 종양에서 CD44 변이형 발현, 미세혈관밀도, VEGF 발현과 HPV 16/18 감염과의 연관성

김현찬,윤혜경,이정형 대한부인종양 콜포스코피학회 2000 Journal of Gynecologic Oncology Vol.11 No.3

Objective: In the development of squamous neoplasia of the uterine cervix, high risk HPV infection has been followed by CD44 variant expression and angiogenesis. The aim of this study is to evaluate the sequential changes and relatianship of CD44 variant expression, microvessel density (MVD), and VEGF expression in CIN III, microinvasive (MI) and invasive (CA) squamous cell carcinoma. Methods: The materials were 17 cases of CIN III, 14 cases of MI and 15 cases of CA. In situ PCR for HPV 16/18 and immunohistochemical studies for CD44std, v6, v7/8, CD 31 for MVD, and VEGF were performed. Results: CD44std expression was decreased in squarnous neoplasia compared to normal, and CD44v6 and v7/8 expressions were increased, however, there was no statistical significance. Accentuated staining of CD44v6 and v7/8 along the infiltrating borders was noted in 76.9% and 69.2% of MI and in 71.4% and 42.9% of CA, respectively. High MVD and VEGF 2+ expression were higher in the squamous neoplasia compared to normal, however, there was no significant difference between the squamous neoplasia and no significant relationship between MVD and VEGF expression. The expression rates of CD44std and CD44v6 were higher in HPV 16/18 negative squamous neoplasia and that of CD44v7/8 was higher in HPV 16/18 pasitive squamous neoplasia, however, their differences were not significant. The incidences of high MVD and VEGF 2+ expression were higher in HPV 16/18 positive suqmaous neoplasia with no statistical significance. Conclusions: These results suggest that CD44 variants expression and angiogenesis are involved in the development of squamous neoplasia of the uterine cervix, however, HPV 16/18 might not be related to CD44 variant expression and angiogenesis.