아급성 골수종과 급성 재활성 만성 B형 간염에서 발생한 I형 저온글로불린혈증 1예

김현제 ( Hyun Je Kim ),홍영훈 ( Young Hoon Hong ),이한솔 ( Han Sol Lee ),김민정 ( Min Jung Kim ) 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.4

저자들은 급성 재활성 만성 B형 간염과 아급성 골수종에 병발한 저온글로불린혈증을 경험하여 이를 보고하는 바이다. A 58-year-old male patient with chronic hepatitis B infection and hypertension was referred for the evaluation of a skin rash. The skin biopsy showed multiple hyaline thrombi in small blood vessels, red blood cell extravasation, and epidermal atrophy. The CBC, chemistry, UA, and radiological studies were unremarkable except for elevated AST/ALT on liver function tests. The hepatitis B virus markers were compatible with the diagnosis of acute replicative phase chronic hepatitis B; HBeAg 86,646 cpm (count per minute), anti-HBeAb (-), HBV PCR (Quantitative) >1.10×108 IU/mL, and >640,200,000 copies/mL. Rouleaux formation was seen on the peripheral blood smears. Serum PEP/IEP demonstrated an M-spike (27.53%) in the gamma region and abnormal bowed arcsin IgG, kappa light chain with Cryoglobulin (+), ANCA (+), FANA (-), and rheumatoid factor (-) on the serological test. The percent of plasma cells on the bone marrow biopsy was approximately 15%. Type I cryoglobulinemia is a rare disease that can be associated with hematologic disorders, but smoldering myeloma or/and hepatitis B has not been reported in association with Type I cryoglobulinemia. Here, we report a case of Type I cryoglobulinemia that showed multiple skin ulcers due to vascular occlusion related to the monoclonal cryoglobulin with smoldering myeloma and acutely reactivated chronic hepatitis B.

How to acquire the best scRNAseq data in dermatology

김현제 ( Hyun Je Kim ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2

소아 청소년기 건선에 대한 임상적 연구

김현제 ( Hyun Je Kim ),김초록 ( Cho Rok Kim ),박지혜 ( Ji Hye Park ),이동윤 ( Dong Youn Lee ),이주흥 ( Joo Heung Lee ),양준모 ( Jun Mo Yang ),이일수 ( Eil Soo Lee ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.10

Background: Few clinical studies are available on childhood and adolescent psoriasis in Korea. Objective: The purpose of this study was to analyze clinical features of childhood and adolescent psoriasis in a referral center in Korea. Methods: We performed retrospective medical record-based analyses for 255 psoriasis patients younger than 16 years of age at the time of diagnosis at our center from March 2001 to July 2010. Age, sex, onset age, familial history, site of involvement, type of psoriasis, nail involvement, initial PASI score, and treatment modality were analyzed. Results: There was no sexual predominance; mean age of onset was 8.85 years; 17.25% of patients had a familial history. Upper extremities, lower extremities, trunk, scalp and face were the most commonly involved sites in sequence. Guttate psoriasis (58.90%) was the most common type of psoriasis. Nail involvement was observed in 11.11% of patients. The mean initial PASI score at the time of diagnosis was 7.9. The most common treatment was topical steroids and topical vitamin D in combination. Conclusion: Childhood and adolescent psoriasis is not an uncommon disease. A larger scale epidemiological study is needed. (Korean J Dermatol 2011;49(10):877∼881)

약물 관련 악골 괴사증(MRONJ) 환자에서 Pentoxifylline and Tocopherol의 효과: 문헌고찰

김무경(Moo-Kyeong Kim),김현제(Hyun-Je Kim),김동혁(Dong-Hyuck Kim),이의석(Eui-Seok Lee),임호경(Ho-Kyung Lim) 대한치과의사협회 2022 대한치과의사협회지 Vol.60 No.11

MRONJ (medication related osteonecrosis of the jaw) is a disease characterized by necrosis of the jaw that occurs after administration of anti-resorptive or anti-angiogenic drugs. However, etiology and effective treatment methods of MRONJ are not yet clearly identified. In this study, a systematic review was conducted to investigate the effects of pentoxifylline and tocopherol on MRONJ. A total of 5 clinical studies using pentoxifyllie and tocopherol in MRONJ patients among the papers registered in Pubmed/medline were reviewed. Pentoxifyllie and tocopherol were used for therapeutic purposes in 32 patients, and the mean age was 68 years for men and 74.21 years for women. Of the 32 patients, 20 patients were stage 2,11 patients were stage 3, and one patient was stage 0. In the most cases, the triggering factor was extraction. All patients complained of pain in the lesion area before drugs administration. The average follow-up period was 10.6 months. After drugs administration, 29 patients (90.6%) showed improvement in symptoms in terms of bone exposure and pain. Administration of pentoxifylline and tocopherol in MRONJ may improve symptoms of pain and bone exposure. However, it seems that additional studies on the appropriate use and dose, timing and duration of administration are needed.

기업 성장의 상대적 가치와 그 의미

이주일(Ju Il Lee),김성구(Sung Gu Kim),김현제(Hyun Je Kim),노규영(Kyu Yeong Roh),원주희(Ju Hee Won),박경민(Kyung Min Park) 연세대학교 경영연구소 2012 연세경영연구 Vol.49 No.1

본 연구는 한국 기업의 성장의 상대적 가치를 살피고, 언제 어떤 전략이 기업의 시장가치 증대에 기여하는지에 대해 실증분석을 실시하였다. 구체적으로 살펴보면, Mass(2005)는 실무적으로 성장 전략을 택할지 혹은 이익향상 전략을 택할지에 대한 기업의 선택이 명확하지 않다고 말한다. 이에 그는 성장의 상대적 가치라는 개념을 제안함으로써, 성장의 상대적 가치에 따라 성장지향 혹은 이익지향을 추구할 것을 권고한 바 있다. 성장의 상대적 가치는 성장과 이익의 개선이 주주의 가치창출에 어떻게 기여하는가를 알아보기 위한 방법으로써, 1%의 추가적인 성장의 가치를 1%의 추가적인 이익의 가치로 나눈 값을 말한다. 그러므로 성장의 상대적 가치가 1보다 큰 기업은 성장지향성 전략을 추구하는 것이 기업성과에 유리한 반면에, 성장의 상대적 가치가 1보다 작은 기업은 이익지향성 전략을 추구하는 것이 기업성과 개선에 일조한다고 할 수 있다. 이와 같은 연구배경 하에서, 상위 200대 한국 기업을 대상으로 한 실증분석 결과, 성장의 상대적 가치가 높은 기업의 성장지향성과 기업성과 간의 관계가 유의하지는 않았으나, 성장의 상대적 가치가 낮은 기업의 이익지향성은 기업성과 증대에 유의미한 영향을 미친다는 사실을 확인할 수 있었다. 또한, 양손잡이 전략은 기업성과 증대에 유의미한 영향을 미치지 못하였을 뿐 아니라 성장의 상대적 가치가 높은 기업의 다각화도 기업성과 증대에 별다른 기여를 하지 못하였음을 확인할 수 있었다. 그러므로 본 연구의 결과는 기업의 의사결정에 유용한 실무적 지침을 제공할 것으로 기대한다. This study investigates the relative value of growth of Korean firms and reveals the type of strategy that helps to increase the market value of those firms more, after weighing the strengths of both growth oriented and profit oriented strategies. Specifically, Mass (2005) argued that managers do not have a clear decision rule on whether to adopt a growth oriented strategy or profit oriented strategy. Therefore he proposed the concept of the relative value of growth (RVG). The RVG approach is an analytic tool for identifying whether a growth oriented strategy contributes to higher firm value or profit oriented strategy leads to higher firm performance. Depending on the level of the RVG, individual firms should focus on either growth oriented strategy or profit oriented strategy. In order to test his arguments, we collected financial data on top 200 firms in Korea from Kis-Value. Our results from the empirical analysis on top 200 firms in Korea show that growth orientation is positively correlated with firm value. Moreover, the RVG of the firms negatively moderates therelationship between profit orientation and the firm value. Therefore, our findings provide mangers with practical guidelines on corporate strategy.

흑색종 환자에서 면역관문 억제제 (Immune Checkpoint Inhibitor)의 효과에 대해 피부과적 부작용 및 영향을 미치는 인자들에 관한 분석: 단일 기관 후향적 연구

윤도경 ( Dokyoung Yoon ),오세진 ( Se Jin Oh ),김현제 ( Hyun Je Kim ),박지혜 ( Ji-hye Park ),이종희 ( Jong Hee Lee ),이동윤 ( Dong-youn Lee ),이주흥 ( Joo-heung Lee ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.4

Background: Programmed death 1 inhibitors enhance pre-existing immune responses by directly blocking anti-programmed cell death receptor-1. They have been widely used these days, but little is known about the dermatologic side effects and the factors affecting the response to therapy. Objective: To determine the association between dermatologic side effects and oncologic response to programmed death 1 inhibitors and to investigate the factors affecting the response to programmed death 1 inhibitors. Methods: We retrospectively reviewed the records of patients with melanoma who were referred to the dermatology department for their newly arising skin lesions after treatment with pembrolizumab and nivolumab from January 1, 2015, to April 30, 2019. The oncologic outcomes of the patients were determined by medical records from the hemato-oncology department. Sex, stage, dermatologic side effects, and age at the time of initial diagnosis were analyzed as the factors affecting oncologic outcomes. Progression-free survival was analyzed between the patients with and those without dermatologic side effects. Results: Of the 177 patients screened for the study, 14 were referred to the dermatology department for cutaneous side effects. There was no difference between the dermatologic side effect group and the non-dermatologic side effect group in terms of oncologic outcome and progression-free survival. Sex and stage significantly increased the risk of disease progression with pembrolizumab treatment. Conclusion: Although it has been reported that there could be a strong association between dermatologic side effects and oncologic outcomes, we were not able to reach the same conclusion among melanoma patients. (Korean J Dermatol 2021;59(4):251∼258)

양뺨에 발생한 발진성 연모 낭종

정규동 ( Kyu Dong Jung ),조혜진 ( Hye Jin Cho ),김평수 ( Pyoung Su Kim ),김현제 ( Hyun Je Kim ),이동윤 ( Dong Youn Lee ),이주흥 ( Joo Heung Lee ),양준모 ( Jun Mo Yang ),이일수 ( Eil Soo Lee ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.4

Eruptive vellus hair cysts (EVHC) are characterized by multiple, small, discrete red or brown colored papules that usually occur on the chest and extremities. Their etiology is unknown. A variant form of EVHC that occur exclusively on the face is rare and it is very characteristic for its location and color. We report here on a facial variant of EVHC that occurred on the face of 23-year-old woman with asymptomatic, skin-colored to bluish tiny papules. The lesions first appeared at the age of 22-years. (Korean J Dermatol 2009;47(4):498~500)

Merkel 세포암 환자들의 임상 양상에 대한 고찰

최영환 ( Younghwan Choi ),배재희 ( Jai Hee Bae ),오세진 ( Se Jin Oh ),김현제 ( Hyun Je Kim ),박지혜 ( Ji-hye Park ),이종희 ( Jong Hee Lee ),이동윤 ( Dong-youn Lee ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.9

Background: Merkel cell carcinoma is an uncommon primary cutaneous neuroendocrine cancer. It is a highly aggressive cancer with high rates of local recurrence and nodal metastasis. While there are some case reports on Korean patients with Merkel cell carcinoma, there has been no comparison study between Western patients and Korean patients regarding its clinical features. Objective: This study aimed to identify the clinical features of Merkel cell carcinoma in Korean patients and compare them with those seen in Western studies. Methods: We retrospectively reviewed the medical records of patients who were diagnosed with Merkel cell carcinoma between January 1995 and May 2019. Clinical features were compared with those seen in Western studies. Results: Thirty-one patients were enrolled in the analysis. The mean age of onset was 67.6 years, and there were more female patients (1:1.58). The head and neck was the most common primary site (38.7%, 12/31). Patients treated by surgical methods alone were the most common (58.1%, 18/31). Twelve patients (38.7%) had recurrence, and seven patients (22.6%) died of Merkel cell carcinoma. Patients younger than 70 years were more frequent in Korea than in Western countries (Fishers exact test, p<0.05). In addition, patients with distant metastasis were less frequent in Korea than in Western countries (Fishers exact test, p<0.05). Conclusion: Compared with Western studies, there were no differences between demographic and clinical features, except that older patients and patients with distant metastasis were less frequent in Korea. (Korean J Dermatol 2020;58(9):583∼589)

소아 흉터 환자에서 초기 레이저 치료의 유용성에 관한 후향적 단일기관 연구

이종은 ( Jongeun Lee ),신동민 ( Dong Min Shin ),장동휘 ( Donghwi Jang ),오세진 ( Se Jin Oh ),김현제 ( Hyun Je Kim ),이종희 ( Jong Hee Lee ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.7

Background: Scars in children are highly concerning to most parents who usually seek prompt treatment for these lesions. However, compared with adults, children show a greater tendency to develop hypertrophic scars and a higher likelihood of scar widening with increasing age. Objective: We investigated the role of laser treatment for scars in pediatric patients in view of the fact that this approach is challenging in this age group. Methods: This retrospective study included patients aged <17 years who visited the Samsung Medical Center between 2013 and 2018 for scar treatment. Of the 28 children who visited the center during this time, 14 presented within 4 to 5 weeks from scar onset and received laser therapy and 14 presented after 4 to 5 weeks and received topical treatment. The Stony Brook Scar Evaluation Scale (SBSES) was used to assess scar formation. Results: The mean initial SBSES scores were lower in the laser than in the topical group (1.93±0.92 vs. 2.71±0.83, p=0.0363). No intergroup difference was observed in SBSES scores upon treatment completion (4.50±0.94 vs. 4.21±1.19, p=0.4673). Multivariable analysis after adjustment for age, sex, and initial SBSES scores showed that the type (laser vs. topical) of treatment was not significantly associated with an SBSES score=5 or duration of treatment. Conclusion: Laser intervention may be useful for scar therapy in children who present early and can receive prompt treatment before scar maturation; however, further studies are warranted to validate our results. (Korean J Dermatol 2021;59(7):507∼512)

肝疾患에 對한 漢方治療劑에 關한 硏究(第Ⅶ報) : 加減淸肝健脾湯의 治療效果에 關한 實驗的 硏究 Experimental Study on the Effect of Kagamchungkankunbi-Tang

金定濟,金賢濟,安秉國,洪元植,金完熙,李尙仁,李學仁,安德均,申珉圭,文濬典,金光湖 慶熙大學校韓醫科大學韓醫學硏究所 1978 慶熙韓醫大論文集 Vol.1 No.-