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Potentilla속 식물의 성분연구 -3, 3', 4-tri-O-methylellagic acid의 분리 및 동정-
김학성,Kim, Hack-Seang 대한약학회 1989 약학회지 Vol.33 No.6
The methylated compound of ellagic acid was isolated from Potentilla chinensis (Rosaceae). The isolated compound was 3, 3', 4-tri-O-methylellagic acid, [2, 3, 7-trimethoxy-8-hydroxy[1] benzopyrano-[5, 4, 3, cde][1] benzopyran-5, 10-dione], $C_{17}H_{12}O_8$, m.p. $293-295^{\circ}C$. The isolation of trimethylellagic acid was conducted by the column chromatography and the identification of the compound was carried out by the methods of IR, NMR and MS spectroscopy.
Antagonism of Analgesic Effect of Morphine in Mice by Ginseng Saponins
김학성,오기완,오세관,Kim, Hack-Seang,Oh, Ki-Wan,Oh, Se-Kwan 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4
Ginseng total saponins(GS), protopanaxadiol saponins(PD) and protopanaxadiol saponins(PT) antagonized the analgesia in mice induced by morphine. The administrations of 2,4-dihydroxyphenylalanine, and 5-hydroxytryptophan reduced the GS, PD and PT antagonisms of morphine analgesia. Possible mechanisms involved in the antagonistic actions of GS, PD and PT on morphine analgesia were described.
해동피성분(海桐皮成分)에 관(關)한 연구(硏究) ( II ) - Hederine의 분리(分離)및 동정(同定)에 대(對)하여 -
김학성,박재영,Kim, Hack-Seang,Park, Jae-Young 한국약제학회 1975 Journal of Pharmaceutical Investigation Vol.5 No.1
Hederine, m. p. $256{\sim}257^{\circ}\;C_{41}H_{64}O_{11}\;{\cdot}\;2H_{2}O$ : $23-hydroxy-3{\beta}-({\beta}-{\alpha}-arabinosidor hamnoside)-olenana-12-ene-oique,$ was obtained from the cortex of Kalopanax pictum. Acid hydrolysis of hederine yielded hederagenin, arabinose and rhamnose. Hederagenin was identified by comparison of it's mixed melting point and IR spectra against authentic sample. Arabinose and rhamnose were identified by TLC against standards.
김학성(Hack Seang Kim),오세관(Sei Kwan Oh),김갑철(Gap Cheol Kim) 한국생약학회 1985 생약학회지 Vol.16 No.1
Intraperitoneal administration of ginseng butanol fraction(GBF) to chronic morphinization in male Sprague-Dawley rats inhibited the development of tolerance to the analgesic effect and hyperthermic action of morphine. Rats were rendered tolerant to morphine by subcutaneous multiple morphine injections for a period of 8 days. The development of tolerance was evidenced by the decreased analgesic response to morphine and inhibition of tolerance by the greater analgesic response. Concomitant administration of morphine with GBF blocked the tolerance to the hyperthermic effect of morphine as evidenced by elevation of body temperature by morphine. Dopamine receptor sensitivity was enhanced in morphine tolerant rats as measured by apomorphine induced in spontaneous motor activity. GBF administration also blocked dopamine receptor supersensitivity induced by chronic morphinization.
모르핀의 내성 및 의존성 형성에 미치는 인삼의 효과(III) -인삼의 Protopanaxadiol 분획 및 Protopanaxatriol 분획의 영향-
김학성(Hack Seang Kim),오세관(Sei Kwan Oh),최강주(Kang Ju Choi),이해빈(Hae Bin Lee) 대한약학회 1985 약학회지 Vol.29 No.4
Protopanaxadiol (PD) fraction and protopanaxatriol (PT) fraction were separated from the butanol fraction of panax ginseng roots. Each group of mice was injected with morphine hydrochloride (40mg/kg s.c.) three times at 8 hr intervals for a period of 6 days. PD fraction and PT fraction were injected (25, 100mg/kg i.p.) to mice 1 hr prior to the third morphine injection daily. Inhibition of morphine tolerance was evidenced by the increase in analgesic response to morphine hydrochloride (10mg/kg i.p.) as estimated by the tail flick method. Inhibition of morphine tolerance by PT fraction was effective but there was no remarkable difference in inhibition of tolerance development between control group and PD fraction group.
김학성(Hack-Seang Kim),박정섭(Jung-Sup Park),박해자(Hae-Ja Park),지형준(Hyung-Joon Chi) 한국생약학회 1980 생약학회지 Vol.11 No.1
A Study of the effects of the root components of Angelica gigas Nakai (Umbelliferae) on voluntary activity in mice has confirmed that there are: 1) MeOH soluble extract, MeOH insoluble extract, decursin and decursinol were antagonized against the voluntary activity in mice pretreated with a dose of caffeine natrium benzoate 30㎎/㎏. 2) MeOH insoluble extract, showed higher depressant effect than MeOH soluble extract. 3) The depressant activity of decursinol was significantly more highly effective than that of decursin.
수종의 생약이 Bovine Adrenal Tyrosine Hydroxylase 및 Dopamine ${\beta}-Hydroxylase$ 활성에 미치는 영향 (II)
황윤정,이승호,김학성,이경순,노재섭,이명구,Hwang, Yoon-Jeong,Lee, Seung-Ho,Kim, Hack-Seang,Lee, Kyong-Soon,Ro, Jai-Seup,Lee, Myung-Koo 한국생약학회 1994 생약학회지 Vol.25 No.2
MeOH extracts of sixteen herbal drugs were tested for the effects on bovine adrenal tyrosine hydroxylase and dopamine ${\beta}-hydroxylase$. The MeOH extracts of Paeoniae Radix and Pinelliae Tuber showed 65% inhibition on the tyrosine hydroxylase activity at the concentration of 100 $\mu$g in the enzyme reaction mixture. Those of Paeoniae Radix, Pinelliae Tuber and Evodiae Fructus showed 87, 84 and 62%, respectively, on the dopamine ${\beta}-hydroxylase$ activity.
Bergenin 및 Acetylbergenin의 Galactosamine 유발 간독성에 대한 치료효과
임화경,최종원,김학성,Lim, Hwa-Kyung,Choi, Jong-Won,Kim, Hack-Seang 한국생약학회 2000 생약학회지 Vol.31 No.3
The hepatoprotective effects of bergenin and its derivative, acetylbergenin, were evaluated against D-galactosamine-induced liver damage in rats. Bergenin is a C-glucoside of 4-O-methyl gallic acid that has been isolated from the cortex of Mallotus japonicus (Euphorbiaceae). Acetylbergenin was synthesized from acetylation of bergenin to increase lipophilic and physiological activities. Bergenin (50, 100 and 200 mg/kg) and acetylbergenin (25, 50 and 100 mg/kg) were administered orally once daily for successive 5 days after the injection of galactosamine (400 mg/kg, i.p.), respectively. The substantially elevated serum enzyme activities of alanine/aspartate aminotransferase, sorbitol dehydrogenase and ${\gamma}-glutamyltransferase$ due to galactosamine treatment were dose-dependently restored towards normalization by post-treatment with bergenin and acetylbergenin. Bergenin and acetylbergenin also significantly prevented the elevation of hepatic malondialdehyde formation and depletion of reduced glutathione content induced by galactosamine in a dose-dependent manner. In addition, the decreased activities of glutathione S-transferase and glutathione reductase were restored towards normalization. These results suggest that effects of bergenin and acetylbergenin may be related to complex mechanisms that involve prevention of lipid peroxidation and preservation of hepatic glutathione. The results of this study clearly indicate that bergenin and acetylbergenin have potent hepatotherapeutic action against galactosamine-induced hepatotoxicity in rats, and lipophilic acetylbergenin is more active in the antihepatotoxic effects against galactosamine than much less lipophilic bergenin.
Erythrosine의 약리학적(藥理學的) 연구(硏究)
김진현,안영란,김학성,Kim, Jin-Hyon,Ahn, Young-Ran,Kim, Hack-Seang 한국약제학회 1982 Journal of Pharmaceutical Investigation Vol.12 No.3
The effects of erythrosine on motility of frog heart, rabbit duodenum and uterus isolated, and on mice intestinal motility and voluntary activity were investigated. The effect of erythrosine $2.3{\times}10^{-5}M$ on isolated frog heart showed a slight decrease of the amplitude of motility, and the heart motility stopped in $3.5{\times}10^{-4}M$. With the administration of erythrosine $3.4{\times}10^{-4}M$, the isolated rabbit duodenum showed a remarkable contraction and this effect was inhibited by atropine $1.4{\times}10^{-7}M$. The administration of erythrosine $2.3{\times}10^{-3}M$, produced a contractile effect on the isolated rabbit uterus, and the motility of $6.9{\times}10^{-3}M$ started to increase in contractions at first and finally stopped, keeping in continuous contractions. The effects of erythrosine 0.5, 1.0, 10, and 20mg/kg on mice intestinal motility were not significantly different from this of the normal control. With 20 and 40mg/kg of erythrosine, the effects on voluntary activity showed the decrease of 21 and 58% respectively, and voluntary activity of the mice pretreated with erythrosine 20 and 40mg/kg, induced by C. N. B. 30mg/kg showed the decrease of 57 and 78% respectively in contrast with the normal control group.
예덕나무피엑스의 사염화탄소 및 갈락토사민 유발 간독성에 대한 보호 및 치료효과
임화경(Hwa Kyung Lim),김학성(Hack Seang Kim),최홍석(Hong Serck Choi),최종원(Jong Won Choi) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.1
Hepatoprotective effects of Malloti cortex extract (MCE) from Mallotus japonicus against the carbon tetrachloride (CCL₄) and galactosamine (GalN) were investigated. Whereas serum aspartate aminotransferase and alanine aminotransferase levels were markedly elevated after CCl₄ and GalN administration, pretreatment and posttreatment with MCE before and after the injection of CCl₄, and GalN resulted in decreases in elevated serum aminotransferase activities. Whereas CCl₄ and GalN treatment caused 3∼7 fold increases in sorbitol dehydrogenase and γ- glutamyltransferase activities, pretreatment and posttreatment with MCE resulted in the blocking of CCl₄ and GalN-induced liver toxicity. The hepatoprotective effect of MCE was in part due to MCE-induced elevation of hepatic glutathione levels. Pretreatment and posttreatment with MCE also reduced increased lipid peroxidation induced by CCl₄ and GalN. These results suggest that MCE may be useful for the prevention and therapy of hepatotoxic pathogenesis. It is presumed that protective and therapeutic effects of MCE due to be inducible glutathione S-transferase and glutathione reductase activities, involving in glutathione-medicated detoxication and maintainment of glutathione content, respectively.